Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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An Evaluation of the Cognitive Effects of a Short-Term and a Long-Term Ovarian Hormone Deprivation in a Transgenic Mouse Model of Alzheimer's Disease: Addressing the Critical Window

Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this…

With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
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Adolescent Prosocial Behavior at SES Extremes

Description
The literature has consistently established levels of adolescent maladjustment well above national norms for both socioeconomic (SES) extremes (Lyman & Luthar 2014). Yet literature on positive adolescent adjustment, and its protective or even corrective factors is lacking (Eisenberg, Zhou, & Coller, 2001). This study examined the effects of gender and…

The literature has consistently established levels of adolescent maladjustment well above national norms for both socioeconomic (SES) extremes (Lyman & Luthar 2014). Yet literature on positive adolescent adjustment, and its protective or even corrective factors is lacking (Eisenberg, Zhou, & Coller, 2001). This study examined the effects of gender and SES on parent attachment in relation to reports of prosocial behavior. Eleventh grade adolescents (N = 397) were recruited from two public high schools for academically-gifted students who were either high or low-level SES (i.e. the extremes). The students provided passive consent and answered questions on their demographics, perceived relationship with their parents, and tendency to behave in a prosocial manner. Multivariate analyses of variance and follow up analyses of variance were run by gender and SES to determine main effects for gender and SES on parent attachment and prosocial behavior. Regressions following preliminary correlations analyzed whether parental attachment predicted higher levels of adolescent prosocial behavior. Results demonstrated that females communicated with their mothers significantly more and reported higher levels of prosocial behavior than their male counterparts. Findings with regard to SES revealed that high SES adolescents reported increased parent attachment, whereas low SES adolescents reported higher levels of community\u2014based prosocial behaviors. Finally, certain dimensions of parent attachment predicted increases and decreases only in specific prosocial behaviors. Because prosocial behaviors change throughout adolescence, future ventures should consider a longitudinal analysis to obtain a more comprehensive picture of adolescent positive adjustment.
ContributorsAli, Hira (Author) / Luthar, Suniya (Thesis director) / Infurna, Frank (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12