Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- Creators: School of Life Sciences
Description
Past studies have shown that exercise in the form of high intensity interval training (HIIT) is the "ideal form of exercise to improve health and performance without overstressing the immune system" (Fisher et. al, 2011, p. 5). Additionally, HIIT has been found to promote cardiovascular health and immunity (Fisher et. al, 2011). The proposed study will evaluate the neuropsychological effects of HIIT on breast cancer patients undergoing anthracycline-based chemotherapy. The intervention group (n = 17) will receive a HIIT protocol concurrent with chemotherapy treatment. There will also be a control group (n= 17) to compare the effects of the intervention. Breast cancer survivorship is often ridden with various health and mental problems, the implementation of HIIT procedures could help to reduce these issues. It is expected that knowledge from this study will be useful in the healthcare setting to benefit breast cancer patients. This study will uniquely add to the limited research base by introducing an intervention for neuropsychological declines in breast cancer patients.
ContributorsNguyen, Ha Vi Song (Author) / Tran, Alisia (Thesis director) / Capco, David (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Abstract The BIO 189 Life Sciences Career Paths course is a seminar course that is intended to acclimate incoming freshmen into the School of Life Sciences (SOLS). While there are instructors who organize and present in the class, upper division undergraduate students are primarily responsible for facilitating lectures and discussions and mentoring the freshmen. Prior research has demonstrated that the mentor-mentee relationship is a very important predictor of success and retention within all university first-year programs. While past studies focused on the student mentor-mentee relationships, there is limited research that measures student satisfaction within freshmen seminar courses, especially in areas of science, technology, engineering, and mathematics (STEM). The purpose of this project is to survey students about their perception of the BIO 189 course. The effort of the project is on pre-health students, as they initiate their undergraduate careers and attempt to achieve acceptance into professional school four years later. Analysis of Likert scale surveys distributed to 561 freshmen revealed that students with an emphasis on "medicine" in their majors preferred a BIO 189 course geared to pre-health interests whereas students seeking an emphasis on research (ecology and cell biology/genetics) sought a BIO 189 course focused on internship and employment opportunities. Assessment of the mentor-mentee relationship revealed that students (n = 561) preferred one-on-one meetings with mentors outside of class (44%) compared to those who preferred interaction in class (30%). A sizable 61.68% of students (n = 548) were most concerned with attaining favorable GPAs, highlighting strong emphasis on academic performance. Overall, 61% of respondents (n = 561) expressed satisfaction with SOLS resources and involvement opportunities, which was hypothesized. These results give substantial insight into the efficacy of a first-year success seminar-mentoring program for college freshmen in STEM.
ContributorsMaalouf, Nicholas Elie (Author) / Haydel, Shelley (Thesis director) / Harrell, Carita (Committee member) / Capco, David (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Herpes simplex virus 2 (HSV-2) is one of the most common sexually transmitted infections (STI), affecting over 267 million women worldwide. HSV-2 causes a chronic, latent infection that increases the risk for acquisition with other STI, including HIV. Currently, there is no vaccine against HSV-2 and novel anti-viral treatments are needed. IL-36γ is a newly characterized cytokine that has been shown to play a role in inflammation and be upregulated in response to microbial infection and tissue damage. We have shown that IL-36γ is expressed in the female reproductive tract (FRT) and is upregulated by HSV-2 infection in vitro and in vivo. IL-36γ in turn induces production of proinflammatory cytokines and chemokines in human vaginal epithelial cells (VEC) that can aid in immune cell recruitment. We hypothesize that IL-36γ is a key regulator of mucosal inflammation in the FRT and functions to limit HSV-2 infection. We have demonstrated that IL-36γ treatment prior to infection protects against HSV-2 replication, disease severity, and promotes survival in a lethal mouse model. Thus, the objective of this study is to understand the mechanisms whereby IL-36γ inhibits HSV-2 replication. To understand the impact of IL-36γ on the HSV-2 lifecycle, we pretreated VEC with IL-36γ and evaluated viral titer during virus attachment and entry, replication, and cell-to-cell spread by plaque assay. Pretreatment with IL-36γ 4h prior to infection did not significantly reduce viral titers in VEC monolayers relative to untreated groups. This suggesting that IL-36γ may play a more significant role in immune cell recruitment during HSV-2 infection. To test this, FRT tissue samples from HSV-2 infected IL-36γ -/- and WT mice were analyzed by histochemistry to characterize immune cell recruitment. No clear pattern was determined for tissue samples in which cell clusters were observed and cell type within recruited clusters was unable to be identified at the current magnification. As these projects continue, the data will aid in elucidating the mechanism and level to which IL-36γ impacts HSV-2 infection in human VEC and FRT models.
ContributorsAlexander, Thessaly E (Author) / Herbst-Kralovetz, Melissa (Thesis director) / Capco, David (Committee member) / Hogue, Ian (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Background: Despite a multitude of health initiatives, obesity rates in America have continued to increase yearly, with obese or overweight people making up two-thirds of the population. Due to a lack of significant results from diet and weight-loss medication, new methods of weight-loss are increasingly considered. This paper looks beyond traditional Western treatments for weight loss and will analyze views and treatments for overweight and obesity in traditional Chinese medicine (TCM).
Methods: Three databases were used to search for papers published after 2010 until October 2019 discussing obesity, overweight and TCM. No forms of Chinese medicine were excluded from the search. Studies were excluded if they did not meet the date criteria or if they overlapped with papers found in other databases.
Results: Six of the selected papers covered acupuncture (electro, balance or catgut embedding acupuncture methods) either jointly with other treatments or alone, one exclusively on moxibustion and three studies on three different types of TCM herbal medicine. Each study showed a statistically significant effect on body mass index (BMI) value decrease or total weight loss (TWL). The six acupuncture papers all showed statistical significance at the 95% CI against control groups (sham acupuncture or no acupuncture) and against before-treatment BMI values or TWL values.
Conclusion: Of the treatments reviewed, almost all acupuncture studies were shown to be consistently effective in treating overweight or obese individuals within this selection of studies, as well as in another meta-analysis. This may be due to acupuncture’s ties to a neuroendocrine mechanism. Future studies should further explore the neuroendocrine connection between acupuncture and weight loss. Herbal medication was also shown to have a significant effect in reducing weight in each study; however, two studies used mice or rats as subjects, therefore understanding the effects on human subjects is limited.
Methods: Three databases were used to search for papers published after 2010 until October 2019 discussing obesity, overweight and TCM. No forms of Chinese medicine were excluded from the search. Studies were excluded if they did not meet the date criteria or if they overlapped with papers found in other databases.
Results: Six of the selected papers covered acupuncture (electro, balance or catgut embedding acupuncture methods) either jointly with other treatments or alone, one exclusively on moxibustion and three studies on three different types of TCM herbal medicine. Each study showed a statistically significant effect on body mass index (BMI) value decrease or total weight loss (TWL). The six acupuncture papers all showed statistical significance at the 95% CI against control groups (sham acupuncture or no acupuncture) and against before-treatment BMI values or TWL values.
Conclusion: Of the treatments reviewed, almost all acupuncture studies were shown to be consistently effective in treating overweight or obese individuals within this selection of studies, as well as in another meta-analysis. This may be due to acupuncture’s ties to a neuroendocrine mechanism. Future studies should further explore the neuroendocrine connection between acupuncture and weight loss. Herbal medication was also shown to have a significant effect in reducing weight in each study; however, two studies used mice or rats as subjects, therefore understanding the effects on human subjects is limited.
ContributorsTung, Kiram Yeo (Author) / Lateef, Dalya (Thesis director) / Capco, David (Committee member) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05