Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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A History and Analysis of Drug Labeling Policy for Pregnant and Lactating Women and Women's Involvement in Clinical Drug Research from 1970 to 2014

Description
The inherent risk in testing drugs has been hotly debated since the government first started regulating the drug industry in the early 1900s. Who can assume the risks associated with trying new pharmaceuticals is unclear when looked at through society's lens. In the mid twentieth century, the US Food and…

The inherent risk in testing drugs has been hotly debated since the government first started regulating the drug industry in the early 1900s. Who can assume the risks associated with trying new pharmaceuticals is unclear when looked at through society's lens. In the mid twentieth century, the US Food and Drug Administration (FDA) published several guidance documents encouraging researchers to exclude women from early clinical drug research. The motivation to publish those documents and the subsequent guidance documents in which the FDA and other regulatory offices established their standpoints on women in drug research may have been connected to current events at the time. The problem of whether women should be involved in drug research is a question of who can assume risk and who is responsible for disseminating what specific kinds of information. The problem tends to be framed as one that juxtaposes the health of women and fetuses and sets their health as in opposition. That opposition, coupled with the inherent uncertainty in testing drugs, provides for a complex set of issues surrounding consent and access to information.
ContributorsMeek, Caroline Jane (Author) / Maienschein, Jane (Thesis director) / Brian, Jennifer (Committee member) / School of Life Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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The Effects of Breast Cancer Screening Activism on Racial Disparities And the Future of the Fight

Description
Breast cancer affects hundreds of thousands of women a year in the United States, and kills tens of thousands. African-American women experience a lower incidence of breast cancer, yet they die at twice the rate of Caucasian women. This disparity demonstrates the ineffectiveness of mammography at decreasing mortality in women…

Breast cancer affects hundreds of thousands of women a year in the United States, and kills tens of thousands. African-American women experience a lower incidence of breast cancer, yet they die at twice the rate of Caucasian women. This disparity demonstrates the ineffectiveness of mammography at decreasing mortality in women at higher risk of late stage diagnosis. In this paper I argue that the continued support of the predominating idea that the benefits of mammograms strictly outweigh their negative effects may be a factor in the continued racial disparity in breast cancer mortality between African-American and Caucasian women. In addition, I will argue that mammograms are less effective for African American women because they are predisposed to later stage diagnosis and the accompanying poorer mortality prognosis due to higher-risk environments caused by varied socio-political status. My claims are supported by studies of incidence rates, survivorship versus mortality rates, screening usage rates, late stage and early stage diagnosis rate, tumor type, and the effects of socioeconomic status on stage of diagnosis. In particular, mortality rates have not decreased parallel with increased mammogram usage, especially in African-American women. Although early stage diagnosis has drastically increased, late stage-diagnosis remains unchanged and higher in African-American women. Tumor types vary by race, and African American women tend to have tumors that are highly prolific and more likely to be metastatic. Socioeconomic factors are more of a marker for breast cancer disparities than race, however race and socio-political structures that embody racism are often intersected.
ContributorsHuper-Holmes, Chloe Lynn (Author) / Lynch, John (Thesis director) / Brian, Jennifer (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2015-05
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The Pharmaceutical Industry and the Opioid Epidemic: The Case of Purdue Pharma and OxyContin

Description
This thesis elucidates the responsibility of the pharmaceutical industry for the current opioid epidemic, an epidemic which caused over 40,000 American deaths in 2016 alone. Twenty years prior, Purdue Pharma unleashed an extended-release formulation of the opioid oxycodone: OxyContin. With this, Purdue began a highly aggressive advertising campaign with the…

This thesis elucidates the responsibility of the pharmaceutical industry for the current opioid epidemic, an epidemic which caused over 40,000 American deaths in 2016 alone. Twenty years prior, Purdue Pharma unleashed an extended-release formulation of the opioid oxycodone: OxyContin. With this, Purdue began a highly aggressive advertising campaign with the primary intention of guaranteeing the success of this drug; however, in doing so, they often neglected to ensure that the information they were propagating was wholly accurate. Previous reform attempts aimed at mollifying this crisis have ultimately fallen short, as they have failed to recognize the true extent of Purdue Pharma's involvement, especially with regard to the underlying issues that led to the initiation and progression of the epidemic. Future improvements should be targeted at the reform of regulatory agencies and insurance companies, as well as the cultural attitudes regarding pain and pain treatment that have been cultivated over the last several years. Ultimately, however, these reforms will likely prove to be insufficient unless the failings of the current healthcare system, including the pharmaceutical industry, are also taken into account.
ContributorsOzeran, Rachel Hoku Lii (Author) / Fong, Benjamin (Thesis director) / Brian, Jennifer (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Diagnosing Autism Spectrum Disorder: Implications for Research, Medicine, and Patients

Description
Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental disorder that is becoming increasingly common. Autism does not yet have a known etiology, nor a definitive diagnostic test, thus making diagnosis a difficult and rarely uniform task. Currently, ASD is behaviorally diagnosed based on criteria defined by the American Psychiatric Association…

Autism Spectrum Disorder (ASD) is a lifelong neurodevelopmental disorder that is becoming increasingly common. Autism does not yet have a known etiology, nor a definitive diagnostic test, thus making diagnosis a difficult and rarely uniform task. Currently, ASD is behaviorally diagnosed based on criteria defined by the American Psychiatric Association in the Diagnostic and Statistical Manual of Mental Disorders (DSM). Recently, a change was made in the criteria from more lenient criteria in DSM-IV-TR, to more narrow criteria laid out by the DSM-V, which supersedes the DSM-IV-TR. This drastic change raised many questions and debates about which set of criteria are better. The more lenient criteria offers a more inclusive diagnosis giving greater access to therapies; while the narrow diagnostic criteria excludes some individuals, creating a more uniform diagnosis that's easier to use in research. This thesis analyzes the change in diagnostic criteria from the DSM-IV-TR to the DSM-V and the effects of these changes on the practices of diagnosis. In addition, it explores the implications of this change for the families of children with autism and for those involved in autism research, examining their respective opinions and interests pertaining to narrow verses broad diagnostic criteria. Building on this analysis, the thesis offers recommendations about diagnostic criteria should be set. It argues that the wellbeing of patients takes priority over the interests of researchers, and thus diagnosis should be done in a way that offers the best prognosis for all children who suffer from autistic symptoms.
ContributorsBremer, Michelle Nichole (Author) / Hurlbut, Ben (Thesis director) / Robert, Jason (Committee member) / Brian, Jennifer (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12

Appearance-Based Shame In Medicine: How It Alters Patient Perception and Future Care

Description

Health service quality is understood to be a crucial determinant in successful patient-physician encounters and patient health. One common feeling that patients have reported experiencing during appointments is shame. We hypothesized that patients who experience appearance-based shame during an appointment are not likely to return to the same physician and…

Health service quality is understood to be a crucial determinant in successful patient-physician encounters and patient health. One common feeling that patients have reported experiencing during appointments is shame. We hypothesized that patients who experience appearance-based shame during an appointment are not likely to return to the same physician and that patients who do not experience appearance-based shame are likely to return to the same physician. This was assessed by conducting an anonymous online survey of 13 questions that served to establish a general foundation for understanding the participants' physical characteristics such as race, age, weight, and gender identity as well as their overall patient-physician relationship and experiences of shame, if applicable. 119 participants were recruited from Arizona State University and a case study was performed individually for five participants of interest. The data analyzed from this study suggests that while appearance-based shame does exist in healthcare spaces, it is not a significant determining factor in patients returning to their physicians. In addition, there was no significant evidence to suggest that patients who do not experience appearance-based shame are either likely or more likely to return to their physician. We hypothesize this could be due to confounding variables such as convenience, accessibility, or insurance limitations which patients may prioritize over feeling ashamed during an appointment. However, more research needs to be conducted to confirm these hypotheses.
ContributorsHolmes, Madison (Author) / Santos, Emily (Co-author) / Kathir, Nehhaa (Co-author) / Fontinha de Alcantara, Christiane (Thesis director) / Roberson, Robert (Committee member) / Brian, Jennifer (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-05

Appearance-Based Shame In Medicine: How It Alters Patient Perception and Future Care

Description

Health service quality is understood to be a crucial determinant in successful patient-physician encounters and patient health. One common feeling that patients have reported experiencing during appointments is shame. We hypothesized that patients who experience appearance-based shame during an appointment are not likely to return to the same physician and…

Health service quality is understood to be a crucial determinant in successful patient-physician encounters and patient health. One common feeling that patients have reported experiencing during appointments is shame. We hypothesized that patients who experience appearance-based shame during an appointment are not likely to return to the same physician and that patients who do not experience appearance-based shame are likely to return to the same physician. This was assessed by conducting an anonymous online survey of 13 questions that served to establish a general foundation for understanding the participants' physical characteristics such as race, age, weight, and gender identity as well as their overall patient-physician relationship and experiences of shame, if applicable. 119 participants were recruited from Arizona State University and a case study was performed individually for five participants of interest. The data analyzed from this study suggests that while appearance-based shame does exist in healthcare spaces, it is not a significant determining factor in patients returning to their physicians. In addition, there was no significant evidence to suggest that patients who do not experience appearance-based shame are either likely or more likely to return to their physician. We hypothesize this could be due to confounding variables such as convenience, accessibility, or insurance limitations which patients may prioritize over feeling ashamed during an appointment. However, more research needs to be conducted to confirm these hypotheses.
ContributorsSantos, Emily (Author) / Kathir, Nehhaa (Co-author) / Holmes, Madison (Co-author) / Fontinha de Alcantara, Christiane (Thesis director) / Brian, Jennifer (Committee member) / Roberson, Robert (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-05
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Publication Guidelines and the Use of Qualitative versus Quantitative Data in the Reporting of Research in Elsevier’s Animal Behaviour

Description
Many journals provide guidelines for their publications, which outline the expectations for authors when submitting an article for publication. Although these guidelines have become common practice for some journals, there is little written regarding the impact that these guidelines have on the reporting of research. This paper aims to provide…

Many journals provide guidelines for their publications, which outline the expectations for authors when submitting an article for publication. Although these guidelines have become common practice for some journals, there is little written regarding the impact that these guidelines have on the reporting of research. This paper aims to provide insight regarding the question of “How do journal guidelines address the reporting of data in scientific journals?” This study does not measure the impact that guidelines have had on the reporting of research and instead aims to use the established methodology of document analysis to develop a new instrument for helping understand how and whether publication guidelines impact the reporting of data. The work conducted to develop this methodology involved analysis of the language used in publication guidelines and its potential impact on the use of qualitative versus quantitative data in the reporting of animal behavior research. The topic was chosen as animal behavior research often requires the use of both quantitative and qualitative observations when reporting. In this study, we examined the differences in publication guidelines outlined by the Elsevier’s Animal Behaviour between the years 1960 and 2019, to identify any potential influence of the journal’s publication guidelines on the reporting of scientific research in Animal Behaviour. This study highlights three emerging themes (data presentation, types of research topics and paper types) and identifies supporting language in the guidelines that address the use of qualitative and quantitative terms in the reporting of scientific research.
ContributorsVazquez, Luis Armando (Author) / Briggs, Georgette (Thesis director) / Brian, Jennifer (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
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The Ethics of Defining Somatic and Germline Genetic Modifications: Where Should the Line Be Drawn?

Description
Genetic engineering and gene alterations are a very rich and complex issue that have been the talk of many ethical debates. Somatic and germline genetic engineering technologies are becoming more prevalent in the scientific community and could be provided for public use in a matter of time. These technologies raise…

Genetic engineering and gene alterations are a very rich and complex issue that have been the talk of many ethical debates. Somatic and germline genetic engineering technologies are becoming more prevalent in the scientific community and could be provided for public use in a matter of time. These technologies raise bioethical concerns as society recognizes the challenges behind where to draw the line in use of this relatively new science. The basis of this paper is focused around a meta-analysis and systematic assessment of previous publications of major ethical debates to show the complex interests and ideas that need to be reflected and contemplated upon when deciding to genetically alter our species. A short description of background literature takes place first to show the ideas of major philosophers and bioethic figures to introduce these topics. This analysis will then continue with discussion from a religious point of view and the concerns that they have on these technologies. Next, there is a discussion regarding violation of consent, rights, and autonomy. A discussion of the potential consequential grounds of these enhancements on our species and what they could mean for our future takes ensues after this. At the end of this paper, there is a last discussion about the injustice and inequity that could form from these technologies becoming available to the public. These technologies could affect the future of our entire species and drastically shape our society, medicine, and science in ways we could never imagine.
ContributorsHinni, Danielle Nicole (Author) / McGregor, Joan (Thesis director) / Brian, Jennifer (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Systemic Oppression through Microaggressions: An Analysis of Heteronormative Schema in University Healthcare

Description
This project was designed to assess whether Arizona State University’s current Health and Counseling services perpetuate healthcare discrimination against its LGBTQIA+ student population: a pervasive problem that both researchers and patients have observed in the general healthcare landscape--on university campuses and beyond. A two-part online survey, including multiple-choice and free-response…

This project was designed to assess whether Arizona State University’s current Health and Counseling services perpetuate healthcare discrimination against its LGBTQIA+ student population: a pervasive problem that both researchers and patients have observed in the general healthcare landscape--on university campuses and beyond. A two-part online survey, including multiple-choice and free-response questions, was administered to ASU students attending any of the four campuses in order to receive a wide range of student feedback from diverse populations and assess the queer and transgender healthcare experience on campus. This survey data was used to pinpoint gaps and/or problems in student care and to assess how these concerns might be addressed. Results showed that a number of participants experienced discrimination, including incorrect references to gender pronouns, name preferences, and sexual identity. In response to survey participants’ desire for clearer information about health care services, a prototype for a resource pamphlet and corresponding mock-up of an online platform were created. These prototype resources clearly outline information about the sexual, mental, and physical health resources provided by ASU and include supplementary off-campus programs to fill the gaps in university services. Additionally, these findings were used to create a prototype that could be used to help ensure healthcare workers are familiar with LGBTQIA+ specific healthcare needs.
ContributorsJocque, Meta Elizabeth (Co-author) / Sells, Emma (Co-author) / Miller, April (Thesis director) / Brian, Jennifer (Committee member) / Van Engen, Dagmar (Committee member) / Department of Psychology (Contributor) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05