Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
Displaying 1 - 2 of 2
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- All Subjects: High-intensity Interval Training
- Creators: School of Nutrition and Health Promotion
Description
Doxorubicin (DOX) is a cardiotoxic, anthracycline-based, anti-neoplastic agent that causes pathological cardiac remodeling due to altered protein expression associated with cardiotoxicity. DOX cardiotoxicity causes increased Akt phosphorylation, blunted AMPK phosphorylation and upregulated mTOR phosphorylation. Akt is activated by cellular stress and damage. AMPK is activated by increases in AMP and ADP concentrations and decreased ATP concentration. mTOR is active in cellular growth and remodeling. These proteins are cellular kinases with cascades that are influenced by one another. Exercise preconditioning may diminish the cardiotoxic effects on these proteins. Female, Ovariectomized Sprague-Dawley rats (N=33) were randomized to: Exercise+DOX (EX+DOX, n=9); Exercise+Vehicle (EX+VEH, n=8); Sedentary+DOX (SED+DOX, n=8); and Sedentary+Vehicle (SED+VEH, n=8) groups. DOX (4mg/kg) or VEH (saline) intraperitoneal injections were administered bi-weekly (cumulative dose of 12mg/kg). VEH animals received body weight matched volumes of saline based on dosing in animals receiving DOX. Exercise (EX) animals underwent high intensity (85-95% VO2 peak) interval training (HIIT) (4x4 min bouts) separated by low intensity (50-60% VO2max) intervals (2 min bouts) 5 days per week. Exercise began 1 week prior to the first injection and was continued throughout the study. Rats were euthanized 5 days after the last injection. Left ventricular tissue was isolated, processed into lysate and used for western blot analyses [2x2 ANOVA; (α=0.05)]. DOX induced significant phosphorylation of Akt and mTOR (p=0.035; p=0.032) only in SED+DOX rats, but unchanged in EX+DOX rats. No significant differences (p=0.374) in AMPK phosphorylation were observed between groups. Exercise Preconditioning prevents some DOX-induced changes in the cardiac mTOR signaling pathway implicated in pathological remodeling.
ContributorsPanknin, Timothy M (Author) / Angadi, Siddhartha (Thesis director) / Sweazea, Karen (Committee member) / Dickinson, Jared (Committee member) / School of Nutrition and Health Promotion (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This study examined upper extremity function, including manual dexterity, in chronic stroke survivors following a 10-week high intensity interval treadmill walking intervention. Six stroke survivors completed two 35-minute high intensity interval treadmill walking sessions based on ventilatory threshold per week. In addition, each participant completed one 30-minute low-intensity walking session at home. Participants completed upper extremity and manual dexterity testing at baseline, acutely, and after the 10-week intervention. Contrary to the prediction made, significant improvements in both paretic and non-paretic upper-extremity function including manual dexterity were not found. While time to complete the Nine Hole Peg Test (9HPB) somewhat decreased and the number of blocks transferred in the Box and Blocks Test (BBT) slightly increased, results were not found to be statistically significant. The results do suggest, nonetheless, that high intensity interval treadmill training may lead to improvements in upper extremity function and potentially daily living in chronic stroke survivors.
ContributorsHatty, Laura Elizabeth (Author) / Ringenbach, Shannon (Thesis director) / Bosch, Pamela (Committee member) / Holzapfel, Simon (Committee member) / School of Nutrition and Health Promotion (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05