Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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Genetic influences on the dynamics of pain and affect in fibromyalgia

Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the…

Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
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Daily Rumination and Diurnal Cortisol: The Role of Bicultural Competence and Gender

Description

Latinos make up the fastest growing ethnic minority group in the United States and are at higher risk for the developmental of internalizing symptoms in adolescence than other ethnic groups (Merikangas et al., 2010). Rumination has been identified as a transdiagnostic risk factor associated with several internalizing disorders such as…

Latinos make up the fastest growing ethnic minority group in the United States and are at higher risk for the developmental of internalizing symptoms in adolescence than other ethnic groups (Merikangas et al., 2010). Rumination has been identified as a transdiagnostic risk factor associated with several internalizing disorders such as depression, anxiety, and comorbidities of the two (McLaughlin & Nolen-Hoeksema, 2011; Nolen-Hoeksema et al., 2008). Further, indicators of the hypothalamic-pituitary-adrenal (HPA) axis (i.e., flatter diurnal cortisol slopes [DCS] and greater cortisol awakening responses [CAR]) are associated with greater risk of internalizing disorders and chronic stress (Adam et al., 2010; Adam et al., 2017). Notably, no studies have examined the association between rumination and the diurnal cortisol slope in Latino populations, and literature on the relation of rumination and the CAR is mixed (Cropley et al., 2015; Hilt et al., 2017; Zoccola et al., 2011). Leveraging self-reported rumination as well as gold-standard salivary cortisol collection procedures (Stalder et al., 2016), the current study sought to elucidate associations between daily rumination and diurnal cortisol in an adolescent Latino sample by examining gender differences and bicultural competence as potential moderators of this association. Results indicated a significant but small association between night-before rumination on problems/stress and next-day DCS. Further, gender differences were detected in the effects of same-day rumination and the CAR. Greater rumination on feelings was associated with a smaller CAR the same day in males, while greater rumination on problems/stress was linked with a greater CAR the same day in females. In addition, there were no buffering effects of bicultural competence. Findings inform future research regarding potential bidirectional relations of daily rumination and the CAR, as well was how different kinds of daily rumination may have differing associations with the CAR of males and females.
ContributorsTrent, Kevin (Author) / Doane, Leah (Thesis director) / Davis, Mary (Committee member) / Cruz, Rick (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2023-05