Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
While previous research has investigated the influence parenting styles have on child behavior, there has not been consistent findings on how child behavior in return influences parenting. This study goes beyond the literature by examining bidirectional influences of combined dyad for emotional availability and early problem behaviors (composited across 12 and 30 months) predicting parental warmth, authoritarian parenting, internalizing, externalizing and ADHD symptoms at age eight. This study also examined whether genetic or environmental factors were driving these behaviors. Participants were from the ongoing Arizona Twin Project (N=340 twin children). 25% of the twins were monozygotic, 35% were same-sex dizygotic, and 35% were opposite-sex dizygotic twins. Preliminary correlations showed bidirectional effects between early emotional availability, problem behaviors and parental warmth, authoritarian parenting, internalizing, externalizing and ADHD symptoms at age eight; however, once twin dependence and covariates were controlled for, the bidirectional effects were no longer significant. One important finding emerged: early problem behaviors were predictive of later problem behaviors at eight years. The study also found that externalizing and ADHD symptoms were more heritable than emotional availability, early problem behaviors, and internalizing symptoms. Therefore, interventions should be developed addressing the environmental influences that contribute to early problem behaviors.
ContributorsKaur, Navneet (Author) / Lemery-Chalfant, Kathryn (Thesis director) / Miadich, Samantha (Committee member) / Davis, Mary (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05