Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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Genetic influences on the dynamics of pain and affect in fibromyalgia

Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the…

Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011

Opioid Overdose Education, Knowledge, and Behavior Among First-Year Sorority and Fraternity Members at Arizona State University

Description

The opioid crisis is a dangerous public health issue on the rise among college students involved in Greek organizations. This study investigated what first-year students involved in National Panhellenic Conference (NPC) sororities and Interfraternity Council (IFC) fraternities at Arizona State University (ASU) know about opioids and how to react in…

The opioid crisis is a dangerous public health issue on the rise among college students involved in Greek organizations. This study investigated what first-year students involved in National Panhellenic Conference (NPC) sororities and Interfraternity Council (IFC) fraternities at Arizona State University (ASU) know about opioids and how to react in the event of an opioid overdose to provide recommendations for ASU. Data was collected by surveying first-year NPC and IFC students at ASU on their knowledge and behavior patterns regarding opioids and overdoses. Additionally, a series of interviews with large public universities in the United States were conducted to discuss resources available to students. It was found that the fraternity and sorority members surveyed have an inadequate amount of knowledge about opioids and overdoses, but have less experiences with opioids and/or overdoses compared to non-Greek affiliated students at ASU. It is believed that with proper education and access to resources, students will decrease their risk of experiencing an overdose. This research provided the basis to argue for educational programs and resources being provided to students at ASU.
ContributorsShami Sher, Olivia (Author) / Katzman, McKenna (Co-author) / Kappes, Janelle (Thesis director) / Wynn, Bridgette (Committee member) / Barrett, The Honors College (Contributor) / Department of Marketing (Contributor) / Department of Management and Entrepreneurship (Contributor)
Created2023-05

Opioid Overdose Education, Knowledge, and Behavior Among First-Year Sorority and Fraternity Members at Arizona State University

Description

The opioid crisis is a dangerous public health issue on the rise among college students involved in Greek organizations. This study investigated what first-year students involved in National Panhellenic Conference (NPC) sororities and Interfraternity Council (IFC) fraternities at Arizona State University (ASU) know about opioids and how to react in…

The opioid crisis is a dangerous public health issue on the rise among college students involved in Greek organizations. This study investigated what first-year students involved in National Panhellenic Conference (NPC) sororities and Interfraternity Council (IFC) fraternities at Arizona State University (ASU) know about opioids and how to react in the event of an opioid overdose to provide recommendations for ASU. Data was collected by surveying first-year NPC and IFC students at ASU on their knowledge and behavior patterns regarding opioids and overdoses. Additionally, a series of interviews with large public universities in the United States were conducted to discuss resources available to students. It was found that the fraternity and sorority members surveyed have an inadequate amount of knowledge about opioids and overdoses, but have less experiences with opioids and/or overdoses compared to non-Greek affiliated students at ASU. It is believed that with proper education and access to resources, students will decrease their risk of experiencing an overdose. This research provided the basis to argue for educational programs and resources being provided to students at ASU.
ContributorsKatzman, McKenna (Author) / Sher, Olivia (Co-author) / Kappes, Janelle (Thesis director) / Wynn, Bridgette (Committee member) / Barrett, The Honors College (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Hugh Downs School of Human Communication (Contributor)
Created2023-05