Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- All Subjects: Opioids
Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
702,000 and counting. That is the estimated figure of deaths related to drug overdoses from 1997-2017 reported by the CDC. Almost 70% of those deaths can be attributed to prescribed or illicit opioids. Many have been quick to place blame and unsurprisingly no one seems to be coming forward to take responsibility. What was the cause of this crisis? A current lawsuit against Purdue Pharma alleges that they are responsible for not only starting but continuing the crisis. (Strickler 2019) One of the initial indications of how the crisis started was due to unprofessional and deceptive sales tactics. Along with this, there have been many unethical practices involving advertising of various pharmaceutical products to exacerbate the issue. These practices range from general advertising to holding conferences with Doctors. Considering how many different parties are involved with the production, sale, prescription, and use of these products I find it difficult to place blame on one party. I wanted to specifically research how sales representatives build trust and relationships with their clients within this industry and how the crisis itself has impacted these relationships. The majority of my research consists of the foundation of relationships, different types of relationships, and how to build and maintain productive relationships. Relationships can be difficult, especially in a professional sales environment because each party typically has their own interests throughout each interaction. By understanding how professional relationships can be built we can aim to avoid a crisis like this in the future, and ultimately save lives because of it.
ContributorsGriffith, Jacob Marcus (Author) / LaRosa, Julia (Thesis director) / Hass, Mark (Committee member) / Department of Management and Entrepreneurship (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05