Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
To address and evaluate opioid legislation in the United States and its effectiveness in combating the opioid epidemic.
This paper will assess current and past legislation, on both the state and federal level, in terms of its effectiveness by cross-examining it with existing data. This paper also examines failures on the state and federal levels to properly target at-risk groups. Furthermore, this paper makes recommendations for future legislation to properly allocate resources to localities most affected by the opioid epidemic, and contribute to the decrease in opioid-related overdose deaths.
This paper will assess current and past legislation, on both the state and federal level, in terms of its effectiveness by cross-examining it with existing data. This paper also examines failures on the state and federal levels to properly target at-risk groups. Furthermore, this paper makes recommendations for future legislation to properly allocate resources to localities most affected by the opioid epidemic, and contribute to the decrease in opioid-related overdose deaths.
ContributorsKelly, John C (Co-author) / Kapadia, Kajol (Co-author) / Hill, Alexander (Thesis director) / Foote, Nicola (Committee member) / Department of Economics (Contributor) / Dean, W.P. Carey School of Business (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05