Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
There has been a rise in heroin use throughout the United States due to doctors increasingly prescribing painkillers to patients with chronic pain (Kanouse & Compton, 2015; Compton, Boyle, & Wargo, 2015). Individuals get addicted to painkillers and, when their doctor will no longer prescribe them, turn to alternative methods of relief; heroin is often their cheapest option (Kolodny, Courtwright, Hwang, Kreiner, Eadie, Clark, & Alexander 2015). Heroin users are three to four times more likely to die from overdose than other types of drug users (Darke & Hall, 2003). The purpose of this study is to determine the likelihood that heroin users successfully reenter the community upon release from prison in comparison to other types of drug users. There are several re-entry outcomes that can be considered “success”; this study measures success as an index of the quality of the returning offender’s familial relationships as well as recidivism. The data used for this analysis is the Serious and Violent Offender Reentry Initiative (SVORI). The sample consists of male offenders, aged 18 years and older, who have been convicted of and imprisoned for a serious or violent crime. Findings suggest familial social support does not have an effect on heroin use, but heroin use increases the risk of recidivism. These findings will provide a context for rehabilitation of heroin offenders and will launch future research focusing on the differences between heroin users and other types of drug users.
ContributorsGriffin, Amber (Author) / Wallace, Danielle (Thesis advisor) / Wright, Kevin (Committee member) / Chamberlain, Alyssa (Committee member) / Arizona State University (Publisher)
Created2016