Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- All Subjects: ADHD
- All Subjects: Temperament
Description
The frontostriatal reward circuit serves an underlying role in reward processing, cognitive planning, and motor control in the context of achieving a goal. Furthermore, research suggests a relationship between the reward circuits and behavior expressed in Attention Deficit Hyperactivity Disorder (ADHD); however, the specific structural differences of the reward circuits in those with ADHD remain ambiguous. Diffusion tensor imaging (DTI) techniques were used to analyze diffusion weighted magnetic resonance imaging (DWI) data in order to examine the structural connectivity of frontostriatal reward pathways in ADHD adolescents compared to typically developing (TD) adolescents. It was hypothesized that measures of impulsivity would be predicted by white matter tract integrity measures in frontostriatal tracts related to affective processing (ventromedial prefrontal cortex to ventral striatum, vmPFC) in adolescents with ADHD, and that there would be reduced tract integrity in tracts related to executive control (dorsolateral prefrontal and anterior cingulate cortex—dlPFC and ACC, respectively). Frontostriatal tracts as well as the hippocampus and amygdala were examined in relation to age and impulsivity using both correlation and regression models. Results indicated that impulsivity declined with age in the TD group while no significant trend was identified for the ADHD group. The hypotheses were not supported and results for both predictions on the affective and executive circuits showed opposite trends from what was expected.
ContributorsHarrison, Sydney Rae (Author) / McClure, Samuel (Thesis director) / Brewer, Gene (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Approximately 20% of youth experience mental health problems (Vasileva et al., 2021), and dimensions of early childhood temperament, specifically negative affectivity and effortful control, predict later mental health (Rothbart, 2007). Examining temperament using person-centered methods, particularly in stressful contexts, may improve our understanding of vulnerability to adolescent emotional problems. The current study examined whether specific patterns, or types, of infant temperament longitudinally predicted adolescent anxiety and depression symptoms and whether family relationship stress moderated this association. We hypothesized that infants with a Negative Dysregulated temperament would experience higher anxiety and depression symptoms in later childhood compared to those with a Typical Expressive temperament, and that family relationship stress would exacerbate this link. In an ongoing-longitudinal study of families with twins (N=563, 51% female, 29.8% Hispanic/Latinx, 58.4% White; Lemery-Chalfant et al., 2019), primary caregivers (PCs) reported on infant temperament at 12 months (IBQ; Gartstein & Rothbart, 2003, α=.74-.90). In a prior study (Murillo et al., 2023), latent profile analysis yielded three infant temperament types: Negative Dysregulated, Positive Well-Regulated, and Typical Expressive. PCs reported on partner strain (PSS; Schuster, Kessler, & Asseltine, 1990, α=.87) and family conflict (FCS; Porter & O’Leary, 1980, α=.80) at age 8 and a composite of these two measures represented Family Relationship Stress (r = .689). Confirmatory factor analysis was used to form Depression and Anxiety outcome composites based on PC (4 reports), secondary caregiver (2 reports), teacher (2 reports), and self-report (3 reports) measures of depression and anxiety symptoms collected from ages 8-11 (HBQ, Armstrong & Goldstein, 2003; BPI, Measelle et al., 1998, all α’s > .80). We randomly selected one twin from each pair and conducted regression analyses, and then used the second twin for an internal replication. Family relationship stress had a significant main effect on both anxiety and depressive symptoms. The Negative Dysregulated temperament type did not predict anxiety and depression at ages 8-11, however, it interacted with family relationship stress to predict anxiety and depression in 1 of 2 samples. When family relationship stress was low, the Negative Dysregulated type was significantly associated with higher anxiety and depression outcomes compared to the Typical Expressive type, and high family relationship stress was significantly associated with lower depression outcomes. Elucidating these longitudinal relations is important for informing early intervention and reducing the burden of adolescent psychopathology.
ContributorsSingh, Ajuni (Author) / Lemery-Chalfant, Kathryn (Thesis director) / Corbin, William (Committee member) / Davis, Mary (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor)
Created2023-12