Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- All Subjects: Alzheimer's Disease
- All Subjects: evolutionary psychology
Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
This paper explores the idea of xenophilia and the circumstances under which it may occur. Xenophilia is the preference for an outgroup member over an ingroup member. This preference does not have to be amicable, and in fact can be exploitative under certain circumstances. Previous research indicates that xenophobia is much more common, but a few researchers have found support for the existence of xenophilia. To experimentally test the circumstances under which xenophilia might occur, I conducted a survey-based experiment on Amazon’s Mechanical Turk. This consisted of directed visualizations that manipulated participant goal (self-protection vs. mate acquisition) and the resources offered by both a fictitious outgroup and the hometown ingroup, followed by measures of ingroup/outgroup preference. I hypothesized that when the resource offered by the group addressed the participants’ goal, they would prefer the group with the “matched” resource—even if it was the outgroup providing that resource. My hypothesis was not supported, as the univariate analysis of variance for preference for the outgroup was not significant, F (2, 423) = .723, p = .486. This may have occurred because the goal manipulations were not strong enough to counteract the strong natural preference for ingroup members.
ContributorsDrury, Margaret E. (Author) / Neuberg, Steven (Thesis director) / Davis, Mary (Committee member) / Kenrick, Douglas (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05