Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- All Subjects: Parkinson's disease
- Creators: Turaga, Pavan
Description
At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together with machine learning tools to automate the process of Parkinson’s disease classification and severity assessment. An automated, stable, and accurate method to evaluate Parkinson’s would be significant in streamlining diagnoses of patients and providing families more time for corrective measures. We propose a methodology which incorporates TDA into analyzing Parkinson’s disease postural shifts data through the representation of persistence images. Studying the topology of a system has proven to be invariant to small changes in data and has been shown to perform well in discrimination tasks. The contributions of the paper are twofold. We propose a method to 1) classify healthy patients from those afflicted by disease and 2) diagnose the severity of disease. We explore the use of the proposed method in an application involving a Parkinson’s disease dataset comprised of healthy-elderly, healthy-young and Parkinson’s disease patients.
ContributorsRahman, Farhan Nadir (Co-author) / Nawar, Afra (Co-author) / Turaga, Pavan (Thesis director) / Krishnamurthi, Narayanan (Committee member) / Electrical Engineering Program (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
There has been tremendous technological advancement in the past two decades. Faster computers and improved sensing devices have broadened the research scope in computer vision. With these developments, the task of assessing the quality of human actions, is considered an important problem that needs to be tackled. Movement quality assessment finds wide range of application in motor control, health-care, rehabilitation and physical therapy. Home-based interactive physical therapy requires the ability to monitor, inform and assess the quality of everyday movements. Obtaining labeled data from trained therapists/experts is the main limitation, since it is both expensive and time consuming.
Motivated by recent studies in motor control and therapy, in this thesis an existing computational framework is used to assess balance impairment and disease severity in people suffering from Parkinson's disease. The framework uses high-dimensional shape descriptors of the reconstructed phase space, of the subjects' center of pressure (CoP) tracings while performing dynamical postural shifts. The performance of the framework is evaluated using a dataset collected from 43 healthy and 17 Parkinson's disease impaired subjects, and outperforms other methods, such as dynamical shift indices and use of chaotic invariants, in assessment of balance impairment.
In this thesis, an unsupervised method is also proposed that measures movement quality assessment of simple actions like sit-to-stand and dynamic posture shifts by modeling the deviation of a given movement from an ideal movement path in the configuration space, i.e. the quality of movement is directly related to similarity to the ideal trajectory, between the start and end pose. The S^1xS^1 configuration space was used to model the interaction of two joint angles in sit-to-stand actions, and the R^2 space was used to model the subject's CoP while performing dynamic posture shifts for application in movement quality estimation.
Motivated by recent studies in motor control and therapy, in this thesis an existing computational framework is used to assess balance impairment and disease severity in people suffering from Parkinson's disease. The framework uses high-dimensional shape descriptors of the reconstructed phase space, of the subjects' center of pressure (CoP) tracings while performing dynamical postural shifts. The performance of the framework is evaluated using a dataset collected from 43 healthy and 17 Parkinson's disease impaired subjects, and outperforms other methods, such as dynamical shift indices and use of chaotic invariants, in assessment of balance impairment.
In this thesis, an unsupervised method is also proposed that measures movement quality assessment of simple actions like sit-to-stand and dynamic posture shifts by modeling the deviation of a given movement from an ideal movement path in the configuration space, i.e. the quality of movement is directly related to similarity to the ideal trajectory, between the start and end pose. The S^1xS^1 configuration space was used to model the interaction of two joint angles in sit-to-stand actions, and the R^2 space was used to model the subject's CoP while performing dynamic posture shifts for application in movement quality estimation.
ContributorsSom, Anirudh (Author) / Turaga, Pavan (Thesis advisor) / Krishnamurthi, Narayanan (Committee member) / Spanias, Andreas (Committee member) / Arizona State University (Publisher)
Created2016
Description
Information processing in the brain is mediated by network interactions between anatomically distant (centimeters apart) regions of cortex and network action is fundamental to human behavior. Disruptive activity of these networks may allow a variety of diseases to develop. Degradation or loss of network function in the brain can affect many aspects of the human experience; motor disorder, language difficulties, memory loss, mood swings, and more. The cortico-basal ganglia loop is a system of networks in the brain between the cortex, basal ganglia, the thalamus, and back to the cortex. It is not one singular circuit, but rather a series of parallel circuits that are relevant towards motor output, motor planning, and motivation and reward. Studying the relationship between basal ganglia neurons and cortical local field potentials may lead to insights about neurodegenerative diseases and how these diseases change the cortico-basal ganglia circuit. Speech and language are uniquely human and require the coactivation of several brain regions. The various aspects of language are spread over the temporal lobe and parts of the occipital, parietal, and frontal lobe. However, the core network for speech production involves collaboration between phonologic retrieval (encoding ideas into syllabic representations) from Wernicke’s area, and phonemic encoding (translating syllables into motor articulations) from Broca’s area. Studying the coactivation of these brain regions during a repetitive speech production task may lead to a greater understanding of their electrophysiological functional connectivity. The primary purpose of the work presented in this document is to validate the use of subdural microelectrodes in electrophysiological functional connectivity research as these devices best match the spatial and temporal scales of brain activity. Neuron populations in the cortex are organized into functional units called cortical columns. These cortical columns operate on the sub-millisecond temporal and millimeter spatial scale. The study of brain networks, both in healthy and unwell individuals, may reveal new methodologies of treatment or management for disease and injury, as well as contribute to our scientific understanding of how the brain works.
ContributorsO'Neill, Kevin John (Author) / Greger, Bradley (Thesis advisor) / Santello, Marco (Committee member) / Helms Tillery, Stephen (Committee member) / Papandreou-Suppapola, Antonia (Committee member) / Kleim, Jeffery (Committee member) / Arizona State University (Publisher)
Created2021