Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
Displaying 1 - 10 of 11
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- All Subjects: Addiction
- Creators: Department of Psychology
Description
The use of synthetic cathinones or "bath salts" has risen dramatically in recent years with one of the most popular being Methylendioxypyrovalerone (MDPV). Following the temporary legislative ban on the sale and distribution of this compound , a multitude of other cathinone derivatives have been synthesized. The current study seeks to compare the abuse potential of MDPV with one of the emergent synthetic cathinones 4-methylethcathinone (4-MEC), based on their respective ability to lower current thresholds in an intracranial self-stimulation (ICSS) paradigm. Following acute administration (0.1, 0.5, 1 and 2 mg/kg i.p.) MDPV was found to significantly lower ICSS thresholds at all doses tested (F4,35=11.549, p<0.001). However, following acute administration (0.3,1,3,10,30 mg/kg i.p) 4-MEC produced no significant ICSS threshold depression (F5,135= 0.622, p = 0.684). Together these findings suggest that while MDPV may possess significant abuse potential, other synthetic cathinones such as 4-MEC may have a drastically reduced potential for abuse.
ContributorsWegner, Scott Andrew (Author) / Olive, M. Foster (Thesis director) / Presson, Clark (Committee member) / Sanabria, Federico (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
Substance abuse disorders affect 15.3 million people worldwide. The field has primarily focused on dopaminergic drugs as treatments for substance use disorders. However, recent work has demonstrated the potential of serotonergic compounds to treat substance abuse. Specifically, the serotonin 1B receptor (5-HT1BR), a Gi-coupled receptor located throughout the mesocorticolimbic dopamine system, has been implicated in the incentive motivational and rewarding effects of cocaine. Our research suggests that the stimulation of 5-HT1BRs produces different effects at various time points in the addiction cycle. During maintenance of chronic cocaine administration, 5-HT1BR stimulation has a facilitative effect on the reinforcing properties of cocaine. However 5-HT1BR stimulation exhibits inhibitory effects on reinforcement during prolonged abstinence from cocaine. The aim of this study was to examine the possibility of a switch in the functional role of 5-HT1BRs in the locomotor effects of cocaine at different time points of chronic cocaine administration in mice. We found that the 5-HT1BR agonist CP 94,253 increased locomotor activity in mice tested one day after the last chronic cocaine administration session regardless of whether the chronic treatment was cocaine or saline and regardless of challenge injection (i.e., cocaine or saline). Yet after abstinence, CP 94,253 induced a decrease in locomotor activity in mice challenged with saline and attenuated cocaine-induced locomotion relative to cocaine challenge after vehicle pretreatment. These findings suggest that a switch in the functional role of 5-HT1BR is observed at different stages of the addiction cycle and further suggest that clinical applications of drugs acting on 5-HT1BR should consider these effects.
ContributorsBrunwasser, Samuel Joshua (Author) / Neisewander, Janet (Thesis director) / Pentkowski, Nathan (Committee member) / Der-Ghazarian, Taleen (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Psychology (Contributor)
Created2014-05
Description
This longitudinal study examines the relations of anger, gender, and intrusive maternal parenting to empathy in toddlers. Participants (247 toddlers at the initial assessment) were assessed in a laboratory at approximately 18 (T1, N = 247), 30 (T2, N = 216), and 42 (T3, N = 192) months of age. Toddlers' observed anger was measured during a toy removal task and maternal intrusiveness was observed during free play between mother and toddler. Reported empathy was measured using questionnaires completed by mothers and fathers. At 18 months, a positive relation between observed anger and reported empathy was found for boys, but not for girls. At 30 months, maternal intrusiveness positively predicted empathy in boys, but it negatively predicted empathy in girls. These findings provide insight about sex differences in the development of empathy and concern for others in early childhood.
ContributorsTravis, Katherine Elizabeth (Author) / Eisenberg, Nancy (Thesis director) / Spinrad, Tracy (Committee member) / Eggum, Natalie (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
In recent years the abuse of synthetic cathinones, "Bath Salts," has increased. The purpose of this study was to analyze two synthetic cathinones, methylone and α-pvp, for hedonic properties or the potential to be abused. This was tested using an intracranial self-stimulation paradigm, a robust measurement for reward. It was found methylone resulted in an abuse potential similar to MDMA, ecstasy, abuse. Moreover, the results for α-pvp showed a high liability for abuse.
ContributorsJohnson, Craig Trevor (Author) / Olive, Foster (Thesis director) / Presson, Clark (Committee member) / Montesano, Mark (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Department of Psychology (Contributor)
Created2013-12
Description
Eat Drink Smoke is an illustrated journal/memoir about trauma, addiction and mental illness. It is a creative project wherein storytelling is used as therapy.
ContributorsGoldberg, Hannah (Author) / Soares, Rebecca (Thesis director) / Dombrowski, Rosemarie (Committee member) / School of Social Work (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
With opioid use disorder (OUD) being an epidemic, it is important to investigate the mechanisms as to why this is so. This study established a self-administration paradigm to model and investigate the mechanisms of polysubstance, sequential use in conjunction with the analysis of withdrawal symptomatology driven by opioid withdrawal. The independent variables were dichotomized into the control group (food/cocaine) and the experimental group (oxycodone/cocaine). We hypothesized that more cocaine would be self-administered on the first day of oxycodone withdrawal. In addition, we hypothesized that somatic signs of withdrawal would increase at 16 hours post-oxycodone self-administration. Finally, we hypothesized that cocaine intake during oxycodone withdrawal would potentiate subsequent oxycodone self-administration. Our findings revealed that animals readily discriminated between the active (food or oxycodone) and inactive levers - but will however require more animals to achieve the appropriate power. Further, the average cocaine infusions across phases exhibited significance between the oxycodone/cocaine and food/cocaine group, with the average cocaine infusions being lower in food than in oxycodone-experienced animals. This implies that the exacerbation of the sequential co-use pattern in this case yields an increase in cocaine infusions that may be driven by oxycodone withdrawal. Further, to characterize withdrawal from oxycodone self-administration, somatic signs were examined at either 0 or 16 hrs following completion of oxycodone self-administration. The oxycodone/cocaine group exhibited significantly lower body temperature at 16 hrs of oxycodone withdrawal compared to 0 hrs. No differences in somatic signs of withdrawal in the food/cocaine group was found between the two timepoints. Oxycodone withdrawal was not found to potentiate any subsequent self-administration of oxycodone. Future research is needed to uncover neurobiological underpinnings of motivated polysubstance use in order to discover novel pharmacotherapeutic treatments to decrease co-use of drugs of abuse. Overall, this study is of importance as it is the first to establish a working preclinical model of a clinically-relevant pattern of polysubstance use. By doing so, it enables an exceptional opportunity to examine co-use in a highly-controlled setting.
ContributorsUlangkaya, Hanaa Corsino (Author) / Gipson-Reichardt, Cassandra (Thesis director) / Olive, M. Foster (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The purpose of this research paper is to evaluate the need for improved communication between physicians and their child patients. There have been great strides to include children in medical conversations with their health care providers but majority of the responsibility is currently being solely placed on the doctors and medical professionals, discouraging children from asserting themselves into the conversation. Currently, as a result of social health care programs, more children than ever before are going to the doctor, many of whom are not used to routine doctor check-ups. This overwhelms doctors with more patients who are unaware of the role they can play in their health experience. This paper proposes a prospective children's book to help bring this awareness to children, specifically to inform them that they are encouraged to be active in their communicative relationship with their doctors. Although many books have addressed normal fears within the doctor's office such as getting a shot, going through a procedure, and being observed by the doctor, none has focused on the communicative relationship between the doctor and patient. The projected book is able to translate the need of active children patients by following a small child's experience of being afraid of a doctor and communicating that fear to the doctor to improve trust between the doctor and the patient which will ultimately encourage the child to discuss all matters with their physician in the future. By improving communication and allowing children to learn how to care for themselves when ill, they ultimately avoid getting sick as frequently and require less doctor visits while improving patient satisfaction of the family and the child patient during health care encounters.
ContributorsBrandt, Madison Kemery (Author) / Parker, John (Thesis director) / Nishida, Tracy (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Resilience is defined as an individual's ability to cope or "bounce back" after experiencing stressful life events (Rew et al., 2001). Survivors of trauma who express high levels of resilience are more likely to experience positive future life outcomes than equally troubled peers with lower resilience scores. It is possible to increase resilience by targeting several core factors: (1) personal competence, (2) sense of belonging, (3) sense of optimism (Lee et al., 2009). I developed an eight-week creative writing curriculum to boost these three core factors in the hopes of both increasing resilience in homeless youth while also introducing creating writing as an effective coping strategy. Each one-hour session included free-form writing exercises, mindfulness practices, writing workshops, and group presentations. Prompts and activities were carefully developed to encourage resilience-building in a group of homeless children and adolescents of ages seven to fourteen at Homeward Bound in Phoenix. With sample writing works and facilitator feedback, this curriculum was designed to be exceptionally easy and cost effective for future implementation. I hope that other organizations in the future will consider implementing this program to help build resilience in youth who have experienced childhood trauma.
ContributorsPopeski, Cara (Author) / Popova, Laura (Thesis director) / Cavanaugh Toft, Carolyn (Committee member) / Pickhart, Kalani (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Polysubstance abuse is far more common than single substance abuse. One of the most widely abused, yet greatly understudied combination of drugs is the simultaneous use of methamphetamine (meth) and alcohol. Because little research has been conducted on the co-abuse of meth and alcohol, it is important to study the behavioral and neural mechanisms underlying the use of both to combat addiction and come closer to finding an effective treatment of this form of drug abuse. This study uses a rodent model to attempt to identify the mechanisms underlying this co-abuse through the stimulation of the medial forebrain bundle (MFB) and thus the activation of the mesocorticolimbic pathway, the brain's pleasure circuit. First, self-stimulation thresholds (the lowest electrical current the rats are willing to respond for) were determined using a process called Discrete Trials Training. This threshold was later used as a baseline measure to reference when the rats were administered the drugs of abuse: meth and alcohol, both alone and in combination. Our overall results did not show any significant effects of combining alcohol and meth relative to the effects of either drug alone, although subject attrition may have resulted in sample sizes that were statistically underpowered. The results of this and future studies will help provide a clearer understanding of the neural mechanisms underlying the polyabuse of meth and alcohol and can potentially lead to more successfully combating and treating this addiction.
ContributorsDrafton, Kaitlyn Marie (Author) / Olive, Foster (Thesis director) / Glenberg, Arthur (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The growing acceptance of divorce has sparked a discussion regarding the distribution of children’s parenting time with each parent. As a result, researchers are evaluating how divorce impacts children and what can be done to improve their wellbeing. This study sought to examine how a child’s age at their parent’s divorce predicts later parent-child relationships and romantic attachment style. Furthermore, it evaluates parenting time as a potential mediator to this relationship. In order to test this mediational model, we distributed a survey to nearly 1,000 college students with divorced parents. This questionnaire was composed of several batteries that assessed the following: their age at their parent’s divorce, the amount of parenting time awarded to each parent after the divorce, their relationship with each parent, and their romantic attachment style, in addition to many other variables that were used as covariates. Given the complexities of divorce, we controlled for potential third variable explanations that were found to be associated with parenting time, parent-child relationships, and romantic attachment style. We hypothesized that younger ages of divorce lead to less parenting time which in turn worsens the father-child relationship and their romantic attachment style. The data supports the mediational model in regard to the father-child relationship with no correlation found between our predictors and attachment style. This highlights the importance of equal parenting time becoming the new standard.
ContributorsSalem, Salma (Author) / Fabricius, William (Thesis director) / Corbin, William (Committee member) / Benitez, Viridiana (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Psychology (Contributor) / Department of English (Contributor)
Created2022-05