Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
The purpose of this thesis study is to widen the understanding of the effect culture on self-improvement. Past research found that Japanese students, when compared to their North American counterparts, are more likely to strive for self-improvement by persisting when they encounter academic setbacks. In addition to North Americans and Asians, this thesis examines South Asians as well. It is hypothesized that South Asians will have similar levels of self-improvement as East Asians. This thesis also looks at possible explanations for why culture affects self-improvement. Two variables, future self-connectedness and growth mindset, are proposed as these explanations. It is hypothesized that culture affects future self-connectedness and growth mindset, and those two variables in turn influence self-improvement.
For this thesis, 100 undergraduate and recent college graduates completed online self-report measures. Results of independent t-tests showed that there were no significant differences between South and East Asians in self-improvement, which is consistent with what was hypothesized. There were also no differences between South and East Asians in future self-connectedness or growth mindset. The two Asian groups were then combined and compared to North Americans. Further independent t-tests were run, and results found that while the trend was as expected and Asians exhibited higher levels of self-improvement than North Americans, they did not exhibit significantly higher levels. There were also no significant differences between North Americans and Asians in growth mindset, however, North Americans had significantly higher levels of future self-connectedness than Asians, contrary to expectation. Results of mediation regressions found that neither future self-connectedness nor growth mindset significantly explained the effect of culture on self-improvement.
For this thesis, 100 undergraduate and recent college graduates completed online self-report measures. Results of independent t-tests showed that there were no significant differences between South and East Asians in self-improvement, which is consistent with what was hypothesized. There were also no differences between South and East Asians in future self-connectedness or growth mindset. The two Asian groups were then combined and compared to North Americans. Further independent t-tests were run, and results found that while the trend was as expected and Asians exhibited higher levels of self-improvement than North Americans, they did not exhibit significantly higher levels. There were also no significant differences between North Americans and Asians in growth mindset, however, North Americans had significantly higher levels of future self-connectedness than Asians, contrary to expectation. Results of mediation regressions found that neither future self-connectedness nor growth mindset significantly explained the effect of culture on self-improvement.
ContributorsShaikjamaludeen, Shaikhameedha (Author) / Kwan, Virginia (Thesis director) / Shiota, Michelle (Committee member) / Davis, Mary (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12