Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Heron Lodge is the hybrid product of sciences, (pre) medicine, and the humanities throughout four years of an undergraduate degree in Medical Studies.
Adaptive therapy utilizes competitive interactions between resistant and sensitive cells by keeping some sensitive cells to control tumor burden with the aim of increasing overall survival and time to progression. The use of adaptive therapy to treat breast cancer, ovarian cancer, and pancreatic cancer in preclinical models has shown significant results in controlling tumor growth. The purpose of this thesis is to draft a protocol to study adaptive therapy in a preclinical model of breast cancer on MCF7, estrogen receptor-positive, cells that have evolved resistance to fulvestrant and palbociclib (MCF7 R). In this study, we used two protocols: drug dose adjustment and intermittent therapy. The MCF7 R cell lines were injected into the mammary fat pads of 11-month-old NOD/SCID gamma (NSG) mice (18 mice) which were then treated with gemcitabine.<br/>The results of this experiment did not provide complete information because of the short-term treatments. In addition, we saw an increase in the tumor size of a few of the treated mice, which could be due to the metabolism of the drug at that age, or because of the difference in injection times. Therefore, these adaptive therapy protocols on hormone-refractory breast cancer cell lines will be repeated on young, 6-week old mice by injecting the cell lines at the same time for all mice, which helps the results to be more consistent and accurate.
Executive functioning (EF) is the cognitive processing of goal-oriented actions that are predictive of important life functioning skills. Middle childhood is an important time for academic achievement and social development. Positive and negative parenting practices were examined in the prediction of several child executive functioning outcomes in middle childhood, this thesis further examined whether early life socioeconomic status moderated such associations. This sample consisted of 708 twins (32% monozygotic, 36% same-sex dizygotic, and 32% opposite-sex dizygotic) with ethnically and socioeconomically diverse backgrounds at two age points, 12 months old (M = 12.5 months, SD = 1.06) and 8 years old (M = 8.41, SD = .40).There was a significant negative main effect between negative parenting and CPT. Further, positive parenting interacted with SES to predict CPT and Digit Span Forward. A significant positive effect was identified between positive parenting and CPT in low SES families, but not high SES families. Interestingly, greater positive parenting was associated with lower Digit Span Forward in high SES families, but not low SES families. These findings suggest that while negative parenting was associated with worse EF across the entire sample, the relationship between positive parenting practices and executive functioning outcomes differed based on early life socioeconomic status. Future research should examine whether various domains of executive functioning may follow different developmental patterns.
Cancer is a disease acquired through mutations which leads to uncontrolled cell division and destruction of normal tissue within the body. Recent increases in available cross-species data of cancer in mammals, reptiles, birds, and other vertebrates has revealed that the prevalence of cancers varies widely across species. Life-history theory suggests that there could be traits that potentially explain some of that variation. We are particularly interested in species that get very little cancer. How are they preventing cancer and can we learn from them how to prevent cancer in humans? Comparative oncology focuses on the analysis of cancer prevalence and traits in different non-human species and allows researchers to apply their findings to humans with the goal of improving and advancing cancer treatment. We incorporate the predictions that animals with larger bodies have evolved better cancer suppression mechanisms than animals with small bodies. Ruminants in the past were larger in size than modern day ruminants and they may have retained cancer defenses from their large ancestors. The strong cancer defenses and small body size combined may explain the low prevalence of cancer in Ruminants. This paper aims to evaluate the presence of benign and malignant neoplasia prevalence across multiple ruminant species following a time of dramatic decrease in body size across the clade. Our aim is to illuminate the potential impact that these shifts in body size had on their cancer prevalence as well as test the statistical power of other key life history variables to predict cancer prevalence.
Participants were 475 twins and their primary caregivers (mean age=8.48; Primary caregivers: 64% White, 36% Hispanic; 53.8% middle class or above). I found no main effects between parental cultural values and child cortisol outcomes and no main effects between parenting behaviors and child cortisol outcomes. However, when exploring the moderating role of race/ethnicity, it was found that, as compared to children of White primary caregivers, children of Hispanic primary caregivers who had higher levels of parental authoritarianism had steeper PM slopes, indicating more adaptive cortisol outcomes. This suggests that the adaptiveness of certain parenting behaviors may differ across racial/ethnic groups such that what is considered to be “good parenting” may not translate across differing racial/ethnic groups. Ultimately, further research should be conducted in order to further explore the impact of race/ethnicity in the outcomes of our children.