Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 10 of 54
Description
Concurrent with the epidemic of childhood obesity (17% of adolescents), an unprecedented world-wide increase in the prevalence of several adiposity-related complications (including fatty liver disease (hepatic steatosis), type 2 diabetes and early cardiovascular disorders) in this age group, has emerged. Two principle environmental variables play an essential role in the development and maintenance of obesity and in disturbing glucose homeostasis: a lack of physical exercise and overnutrition, i.e., high carbohydrate and high fat diets (HFD). It was our laboratory's intention to develop a rodent model to examine whether the metabolic instability observed in human pubertal children is also present in maturing rats and whether a HFD during this maturational period enhances adipose-related complications with or without an increase in body weight. We hypothesized that maturing Sprague-Dawley rats would reveal a profile of metabolic disturbances and that a disruption of the hyperbolic arrangement between insulin sensitivity and insulin release would be evident (statistically significant changes in fasting hyperinsulinemia, insulin resistance, and insulin release) indicating a high risk environment for future cardiometabolic diseases. It was observed that pubertal rats are metabolically impaired and that a HFD substantially enhances metabolic deficits with marked disturbance in insulin sensitivity (hyperinsulinemia). Additionally, substantial lipogenesis was observed in visceral and liver tissue, potentially as a result of hyperinsulinemia. Both phenotypes of maturing rats exposed to a HFD (obesity prone and obesity resistant) demonstrated "metabolic obesity" regardless of physical phenotype. These outcomes have relevance in the context of public health, particularly if lipocentricity is viewed as an essential element in the challenge of preventing and/or treating perturbations to the metabolic health of pubertal children.
ContributorsSmith, John Clark (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
Background: Both puberty and diets composed of high levels of saturated fats have been shown to result in central adiposity, fasting hyperinsulinemia, insulin resistance and impaired glucose tolerance. While a significantly insulinogenic phenotypic change occurs in these two incidences, glucose homeostasis does not appear to be affected. Methods: Male, Sprague-dawley rats were fed diets consisting of CHOW or low fat (LF), High Fat Diet and High Fat Diet (HFD) with supplementary Canola Oil (Monounsaturated fat). These rats were given these diets at 4-5 weeks old and given intraperitoneal and oral glucose tolerance tests(IPGTT; OGTT) at 4 and 8 weeks to further understand glucose and insulin behavior under different treatments. (IPGTT: LF-n=14, HFD-n=16, HFD+CAN-n=12; OGTT: LF-n=8, HFD-n=8, HFD+CAN-n=6). Results: When comparing LF fed rats at 8 weeks with 4 week glucose challenge test, area under the curve (AUC) of glucose was 1.2 that of 4 weeks. At 8 weeks, HFD fed rats AUCg was much greater than LF fed rats under both IPGTT and OGTT. When supplemented with Canola oil, HFD fed rats AUC returned to LF data range. Despite the alleviating glucose homeostasis affects of Canola oil the AUC of insulin curve, which was elevated by HFD, remained high. Conclusion: HFD in maturing rats elevates fasting insulin levels, increases insulin resistance and lowers glucose homeostasis. When given a monounsaturated fatty acid (MUFA) supplement fasting hyperinsulinemia, and late hyperinsulinemia still occur though glucose homeostasis is regained. For OGTT HFD also induced late hyper c-peptide levels and compared to LF and HFD+CAN, a higher c-peptide level over time.
ContributorsRay, Tyler John (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / Towner, Kali (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / W. P. Carey School of Business (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
As the poverty level increases in Arizona, so does the opportunity gap between high- income and low-income students. We believe that all youth regardless of their zip code, the color of their skin, or their family background should see themselves as leaders and scholars in the community. Access to higher education, quite simply should be attainable for all students. The New American University charter that ASU has adopted is inspiring and groundbreaking. We believe this charter underscores the significance of equal access to education. The REACH program embraces the urgency of educational inequity, by enhancing the potential success of high school teenagers, who attend the Boys & Girls Club \u2014 Ladmo Branch in Tempe, Arizona. REACH empowers youth to develop stronger leadership skills, while becoming more involved in their community. We provide an opportunity for these teens to engage in leadership discussions, receive college mentoring/tutoring, and connect with the community and resources that Arizona State University (ASU) has to offer. It is our hope that every REACH teen is inspired to apply for college. REACH strives to provide any support the teens require to be successful throughout the college testing and admission process. REACH works with multiple communities at Arizona State University including the Pat Tillman Scholars, Devils' Advocates, Honors Devils, Changemaker Central, Barrett, The Honors College and W. P. Carey School of Business to organize and lead a group of teens through a remarkable curriculum that will shape the way they view cultural diversity, educational achievement, and leadership. The weekly meetings consist of discussions, creative team-building, critical thinking exercises, and cultural awareness experiences. Demonstrating to the teens, administrators, volunteers, mentors, and tutors the rich culture that Tempe has to offer and the skills and experience that they have to offer their community as well. In this thesis will we present our work developing and implementing the REACH program at the Ladmo Branch of the Tempe Boys and Girls Club from the Spring of 2013 through the Spring of 2015. We will describe the structure of REACH, our weekly leadership curriculum, our assessment and evaluation method, and the supplemental programs that we instituted (i.e., tutoring and mentoring). We will reflect on our successes and the challenges that we faced over the span of three years. We will conclude our thesis with a critical analysis of the program as a whole in order to provide advice for others who want to create and engage in a sustainable, student lead, community action organization.
ContributorsBurba, Monica (Co-author) / Smith, Jenna (Co-author) / Mokwa, Michael (Thesis director) / Eaton, John (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Sustainability (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of International Letters and Cultures (Contributor)
Created2015-05
Description
This Honors thesis is analyzing the Jaipur Prosthetic Foot; we are using a foot from Bhagwan Mahaveer Viklang Sahayata Samiti (BMVSS) to test the durability of the foot and where the critical fatigue points are located. Our testing design will be based off of computer simulation to point out the critical points that the test machinery should accentuate. The machine will be set to sample and save data at interval times throughout the accentuated walking cycle in order to record the point where the foot begins to show wear.
ContributorsChaisson, Nathaniel (Co-author) / Jacobs, Ian (Co-author) / Radda, Nicholas (Co-author) / Henderson, Mark (Thesis director) / Sodemann, Angela (Committee member) / Carberry, Adam (Committee member) / Barrett, The Honors College (Contributor)
Created2015-05
Description
Sickle cell disease is a genetic disorder that can cause substantial helath problems. It is the result of a mutation in the DNA coding for hemoglobin. As a result of changes in two important amino acids, a person suffering from sickle cell disease will have erythrocytes that do not maintain the typical biconcave shape and instead for a crescent shape. Individuals with sickle cell disease may have many health problems tied to their irregular hemoglobin. The unusual shape of the erythrocytes leads to a much shorter cell life, which means that even though bone marrow remains active long past childhood to try to keep up with the loss of erythrocytes, the body is still unable to accommodate the rapid death of erythrocytes. The malformed erythrocytes can also cause vascular occlusion, blocking blood vessels and slowing blood flow. While sickle cell disease has the potential to spread worldwide, it is particularly common in Africa. This may be because people with the sickle cell trait have a high resistance to malaria, making them more likely to survive that ubiquitous disease and pass on their traits to their offspring. However, the mortality rate in young children with sickle cell disease is very high, in part because the spleen, already stressed by filtering out dead erythrocytes, has difficulties filtering out bacteria. One of the keys to stopping the spread of the disease is neonatal screening, but this requires specialized equipment that is fairly uncommon in rural areas, as can be seen in Kenya. Therefore, it would be highly beneficial to develop a more cost-effective and widely available method for testing for sickle cell disease.
ContributorsWold, John (Author) / Caplan, Michael (Thesis director) / LaBelle, Jeffrey (Committee member) / Snyder, Jan (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
This project is a web development effort to improve the web presence of GlobalResolve. Established in 2006, GlobalResolve has directly improved the lives of underprivileged people locally and in underdeveloped nations throughout the world. This social entrepreneurship program at Arizona State University has enhanced the educational experience of students and faculty by involving them in real world projects that have shown direct results. The initiative goes beyond the traditional model of philanthropy but works to establish successful business ventures of solutions to provide sustainable economic development to the underserved communities they work with. GlobalResolve: A Digital Story is a website that was proposed to help improve the current GlobalResolve website and make a more compelling presentation of the program in hopes of attracting new funding for new projects and also student to be involved as problem solvers. The problems seen in the current website are: lack of student testimonials, sense of up keeping, context in the use of multimedia, and best web design practices. The resulting objectives for the new site were: build a product that would assist in publicizing the GlobalResolve program and tell its story to future students and prospects and potential donors. The new website solved these issues by: incorporating student experiences, embedding social media widgets regarding current projects, details of multimedia elements to provide context, and researching and implementing best design practices. The new website was developed to be an interactive experience, delivering the story of the initiative from its beginnings to it current state. The information is presented on a website with data maps, digital timelines, and short video clips, to give a thorough, interesting, and an explanation of GlobalResolve. With the incorporation of photos and graphics to assist, the website was designed to tell a compelling, composing informative yet engaging digital media. This was confirmed by doing a beta test of the website. This project evolved in many ways as an effective ways of relating information. Ultimately, the goal of this thesis was to make a digital case statement for the initiative, in order to create a clear message to prospects and potential donors. The case statement represents GlobalResolve's digital needs and how those needs can be achieved. Using digital tools and marketing, the website was approached as a strategic business plan and meant to deliver a more effective representation of the program, while setting up a template to be used for future use to allow updates that can show the progressive success of GlobalResolve.
ContributorsLopez, Carolina (Co-author) / Jeong, Yihyun (Co-author) / Henderson, Mark (Thesis director) / Reilley, Michael (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor)
Created2015-12
Description
MPV17-related hepatocerebral mitochondrial DNA depletion syndrome, previously known as Navajo Neurohepatopathy (NNH), is a rare genetic disease affecting Navajo children of the American Southwest. These children can suffer from several severe symptoms like brain damage and liver disease, and a diagnosis leads to death by age 10, on average. The only known effective therapy for NNH is a liver transplant. Currently, the disease is diagnosed through a lengthy and expensive process of gene sequencing, but oftentimes patients with the most severe forms of NNH deteriorate quickly; thus a rapid diagnostic would be beneficial to beginning the transplant process as early as possible. Here, Tentacle Probes, a novel technology to detect genetic mutations, were proposed to rapidly and accurately diagnose NNH. Because of Tentacle Probes' double binding site kinetics, they can detect mutations more accurately than other types of genetic probes. Probes specific to the NNH mutation were designed for use with a real-time polymerase chain reaction (PCR) detection platform. Initial synthetic DNA testing of Tentacle Trobes showed capable differentiation between mutated and non-mutated samples. However, experiments to validate those results at Phoenix Children's Hospital before moving to patient samples showed that test viability decreased over time. Efforts to diagnose the issues that led to decreased viability suggested four possible explanations that are as follows (in order of decreasing likelihood): first, undesired products from improper PCR primer design was supported by double bands in DNA gel electrophoresis; second, DNA may have degraded over time or due to repeated cycles of freezing and thawing stock solutions, and this was supported by smeared DNA gel electrophoresis; third, probe degradation, specifically of the fluorescent reporter, is possible; finally, contaminants that inhibit the PCR reaction may have been introduced. A combination of these factors may also have caused the change in assay viability. As a result of these most likely possibilities, new primers were designed and steps suggested to return viability to the assay. Thus, the various limitations and requirements for this Tentacle Probe diagnostic have been identified, and as assay development continues following the promising initial results achieved, we are confident that a rapid method if diagnosing NNH is on its way to help the children afflicted with this devastating disease receive timely access to treatment.
ContributorsThompson, Emily Rose (Author) / Caplan, Michael (Thesis director) / Carpentieri, David (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
I. Executive Summary Projectors are used in more and more live and corporate events and theatrical productions. In these environments, they are subject to a myriad of conditions. These can include extreme temperatures, atmospheric effects and contaminates, shipping and rough handling, and power issues. The goal is to find ways to extend the reliable and economical lifespan of these machines increasing companies ROI and decreasing environmental damage from more frequent production, repair and disposal. The first area studied was the effect removing the covers has on the projector performance. This is important knowledge for both the research protocols followed in this research and in normal use during maintenance and repair. Testing demonstrated that the removal of covers on small consumer projectors has a profound impact on internal temperatures and can even cause overheating due to the covers being used as air ducting. The main focus of this project was finding effective pre-filters for use around haze, fog and other airborne contaminates. This was successful with two material being demonstrated to be cost effective, filter far superior to factory filters alone, and produce acceptable impacts on projector cooling in several models and types of projector. These filters cost typically less than $1 per filter and reduce the ingress of contaminates by 60-80%. Additionally the effects of improper shutdown versus the manufacturers specified shutdown process were tested. It was determined that the projectors where power was unplugged or turned off had components exceed both operating temperatures and temperatures during the normal shutdown. This shows that following the correct shutdown process keeps components cooler leading to a longer component life and therefore longer projector life and decreased repairs.
ContributorsBooth, Kelsey (Author) / Henderson, Mark (Thesis director) / Pinholster, Jacob (Committee member) / Gaddy, Davin (Committee member) / Barrett, The Honors College (Contributor)
Created2014-05
Description
Sickle Cell Disease (SCD) is a prevalent genetic disease in Africa, and specifically in Kenya. The lack of available relevant disease education and screening mean that most don't understand the importance of getting testing and many children die before they can get prophylactic care. This project was designed to address the lack of knowledge with supplemental educational materials to be partnered with an engineering capstone project that provides a low cost diagnostic test.
ContributorsShawver, Jamie Christine (Author) / Caplan, Michael (Thesis director) / Snyder, Jan (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
Access to clean water is an issue that abounds in many areas across the world. It is estimated that over 770 million people lack access to improved sources of water. However, the lack of access to clean water does not just affect people's health; it is a problem that affects three major areas. Because people do not have clean drinking water, millions of school days are missed per year due to water-related disease or children being forced to procure clean water. Also, gender inequalities result from women bearing the majority of the responsibility of walking long distances to find a source of potable water. Therefore, lack of access to clean water affects people's health, their education, and gender equality. The problem is not that there is a lack of technologies to provide clean water; the problem is that these technologies are not being implemented sustainably in the areas that need them most. To bring better access of clean water to people in developing nations, 33 Buckets has designed a distribution platform that uses schools as the central point for water distribution to local communities. A sustainable filtration system will be installed at the school to provide clean water for the people at the school. People in the nearby community will also be able to get free water if they bring their own containers to the school. To maintain the filter and provide it with any repairs that are necessary, water will be sold to nearby businesses lower than the current market prices. These profits will be used to ensure the quality of the filtration system and also to provide educational improvements to the school. An advisory committee made up of men and women will be assembled to run the filtration business and handle the finances. A pilot project to implement this model has been identified as the Rahima Hoque Girls School in rural Bangladesh. The team will travel to Bangladesh in Summer 2014 to install a filter at the school, purchase water testing supplies and containers, and meet with the advisory committee to go over final logistical details. Financial projections show that if the filter operates at 50% of its expected frequency and water is sold 5 days a week for 52 weeks, the school will generate $33,532.31. These profits are more than enough to maintain the system and pay for educational improvements to the school. Once implementation of the site is completed, the project will be monitored to track how the water selling business is operating. If the model is shown to be successful, it can then be scaled to other nearby schools or other countries with water contamination problems.
ContributorsWiegand, Connor James (Author) / Henderson, Mark (Thesis director) / Shrake, Scott (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05