Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 10 of 31
Description
Between 1100-1500 A.D. England was defining its political and economic power in Europe and as a country. The social expectations of women were based on the general beliefs of femininity that stemmed from physiological characteristics and the religious demands of the church. Three women of considerable social and political power changed the dynamics of English monarchy and the position of women in power for the rest of history. Empress Matilda, Eleanor of Aquitaine, and Margaret Beaufort each defined their positions at the time, changing the pre-conceived notions of femininity by acting in what their contemporaries deemed a masculine way. Matilda, Eleanor, and Margaret did not only thrive in their positions of power under the stereotypes developed in the medieval era regarding femininity, but also in the study of their histories they bring to light how women in modern social and political positions of power are still faced with the same medieval notions of femininity. Women today face the same stereotypes and cultural expectations regarding femininity and when those expectations are not met, or when the stereotype is breached, a wave of popular rhetoric in the form of slander and criticism towards them is accepted. Today, modern women criticized in their positions of authority face the difficulty of riding the fence between being perceived as feminine or masculine. The journey of a heroine involves the integration of both masculine and feminine.
ContributorsAnderson, Alexandra Jael (Author) / Facinelli, Diane (Thesis director) / Wheeler, Jacqueline (Committee member) / Barrett, The Honors College (Contributor) / Department of English (Contributor)
Created2014-05
Description
Background: Both puberty and diets composed of high levels of saturated fats have been shown to result in central adiposity, fasting hyperinsulinemia, insulin resistance and impaired glucose tolerance. While a significantly insulinogenic phenotypic change occurs in these two incidences, glucose homeostasis does not appear to be affected. Methods: Male, Sprague-dawley rats were fed diets consisting of CHOW or low fat (LF), High Fat Diet and High Fat Diet (HFD) with supplementary Canola Oil (Monounsaturated fat). These rats were given these diets at 4-5 weeks old and given intraperitoneal and oral glucose tolerance tests(IPGTT; OGTT) at 4 and 8 weeks to further understand glucose and insulin behavior under different treatments. (IPGTT: LF-n=14, HFD-n=16, HFD+CAN-n=12; OGTT: LF-n=8, HFD-n=8, HFD+CAN-n=6). Results: When comparing LF fed rats at 8 weeks with 4 week glucose challenge test, area under the curve (AUC) of glucose was 1.2 that of 4 weeks. At 8 weeks, HFD fed rats AUCg was much greater than LF fed rats under both IPGTT and OGTT. When supplemented with Canola oil, HFD fed rats AUC returned to LF data range. Despite the alleviating glucose homeostasis affects of Canola oil the AUC of insulin curve, which was elevated by HFD, remained high. Conclusion: HFD in maturing rats elevates fasting insulin levels, increases insulin resistance and lowers glucose homeostasis. When given a monounsaturated fatty acid (MUFA) supplement fasting hyperinsulinemia, and late hyperinsulinemia still occur though glucose homeostasis is regained. For OGTT HFD also induced late hyper c-peptide levels and compared to LF and HFD+CAN, a higher c-peptide level over time.
ContributorsRay, Tyler John (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / Towner, Kali (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / W. P. Carey School of Business (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
Sickle cell disease is a genetic disorder that can cause substantial helath problems. It is the result of a mutation in the DNA coding for hemoglobin. As a result of changes in two important amino acids, a person suffering from sickle cell disease will have erythrocytes that do not maintain the typical biconcave shape and instead for a crescent shape. Individuals with sickle cell disease may have many health problems tied to their irregular hemoglobin. The unusual shape of the erythrocytes leads to a much shorter cell life, which means that even though bone marrow remains active long past childhood to try to keep up with the loss of erythrocytes, the body is still unable to accommodate the rapid death of erythrocytes. The malformed erythrocytes can also cause vascular occlusion, blocking blood vessels and slowing blood flow. While sickle cell disease has the potential to spread worldwide, it is particularly common in Africa. This may be because people with the sickle cell trait have a high resistance to malaria, making them more likely to survive that ubiquitous disease and pass on their traits to their offspring. However, the mortality rate in young children with sickle cell disease is very high, in part because the spleen, already stressed by filtering out dead erythrocytes, has difficulties filtering out bacteria. One of the keys to stopping the spread of the disease is neonatal screening, but this requires specialized equipment that is fairly uncommon in rural areas, as can be seen in Kenya. Therefore, it would be highly beneficial to develop a more cost-effective and widely available method for testing for sickle cell disease.
ContributorsWold, John (Author) / Caplan, Michael (Thesis director) / LaBelle, Jeffrey (Committee member) / Snyder, Jan (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
Microvillus Inclusion disease is a fatal disease found in the Navajo population caused by a single nucleotide polymorphism. It is characterized by intractable diarrhea and is often fatal early in life.1 The current method of diagnosis is sending duodenal biopsies for histopathological examination and confirmatory testing through genomic sequencing. The purpose of this experiment was to create a more simple and cost-effective diagnostic method for detecting Microvillus Inclusion disease. Three methods were explored (RFLP2, ARMS3,4, and Tentacle Probes5,6) and two methods were tested to determine their ability and their efficiency in detecting the SNP that causes the disease.2 Tests using the RFLP2 method and synthetic DNA resulted in 9% false-positive rate and 11% false-negative rate in a blind trial for detecting both target (mutation present) and non-target (mutation absent) DNA when gel analyzing software was used to compare Rf values after gel electrophoresis. Using the ARMS method3, a nine-sample randomized test was run that ended up with 22% false-positive rate and 19% false-negative rate from a blind trial when using a gel analyzing software to determine presence of the SNP by band intensity. Disclaimer: No DNA from human patients was used in this study. Only synthetic DNA used.
ContributorsHelmbrecht, Hawley Elizabeth (Author) / Caplan, Michael (Thesis director) / Carpentieri, David (Committee member) / Dubois, Courtney (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Imaging analysis of local drug delivery is important because in both studies involving chemotherapy targeted toward glioblastoma and antimicrobial addressing infection, the drug concentration and distribution are unknown. There are a variety of studies focused on the local delivery of drug to a targeted location, but we are presenting a way of quantifying the concentration of the drug and the distribution of the drug during a period of time. This study aims to do that by utilizing Materialise Mimics to analyze the MRI images of local drug delivery in glioblastoma in canines and antimicrobial gel in rabbit femurs. The focus of the technique is to register the anatomy in T1-weighted spin echo images to the drug delivery in T2 flow attenuated inversion recovery (FLAIR) images in order to see where the drug went and did not go relative to the anatomical part. Both studies focus on addressing effective volumes of drug to a designated anatomical area, in which the delivery can be difficult as it involves bypassing the blood brain barrier in the first study and achieving effective volumes while preventing toxicity to the kidneys in the second study. The goal of this project lies in determining the drug volumes and location for the specified duration and anatomical part.
ContributorsJehng, Hope (Author) / Caplan, Michael (Thesis director) / Sirianni, Rachael (Committee member) / Chemical Engineering Program (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Executive Summary Finding Joy in the Journey is a sports philanthropy project I have designed to connect the Arizona State University Women's Basketball team with girls between the ages of 7-12 in the Phoenix community who have the same love for the game basketball. Through monthly team bonding events over a nine-month season, these young girls are able to build long lasting relationships with their role models and learn how to find the joy in the journey. Finding joy in the journey is key in our fast paced and on the go American lifestyle. The successes and bumps in the road, the good times and the bad, and the people along the way all contribute to help shape us into the people we are today. This program allows for 14 girls to have a scholarship to be on the Jr. ASU women's basketball team. The approximate budget for this project is $3000 per year and covers expenses for food and supplies at monthly team events as well as each of the girls to have season tickets for the ASU women's basketball home games. Funding is provided through boosters and fundraising efforts on the front end. Marketing efforts are made through the ASU Women's Basketball team's partnership with local elementary and middle schools through the character code game, and also through the database of the girls who attend basketball camp. Through a shared love of the game of basketball, ASU Women's Basketball is raising up a young generation of girls to be leaders by inspiring and teaching them all of the lessons the game of basketball can teach us about life.
ContributorsBurke, Joy (Author) / Facinelli, Diane (Thesis director) / Ostrom, Amy (Committee member) / Barrett, The Honors College (Contributor)
Created2013-05
DescriptionThis collection of personal essays offers a glimpse into the experience of studying abroad, moving around within the United States for residence and travel, and the changes of heart and mind that accompany such travels. Provisions have been made for the graphic design, publication and promotion of the physical book.
ContributorsStrauss, Cassandra Lynell Frantz (Author) / Facinelli, Diane (Thesis director) / Dodge, Nancie (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / School of Politics and Global Studies (Contributor)
Created2014-05
DescriptionAn analysis and informal ethnography of the participatory culture in Phoenix, Arizona that identifies itself as "geeky" or "nerdy." Conducted through numerous interviews and academic research, the project looks at this active community under the scope of personal choice and togetherness.
ContributorsHuskinson, Harmony (Author) / Facinelli, Diane (Thesis director) / Scott, Suzanne (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor)
Created2014-05
DescriptionA short, fantasy novel using essential characters, themes, and events as depicted in the Bible.
ContributorsMcDonald, Joshua Dave Mallrich (Author) / Facinelli, Diane (Thesis director) / Bruhn, Karen (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2014-05
DescriptionA look into the historical significance of clothing and clothing construction to self-fashioning.
ContributorsLee, Elizabeth Kristina (Author) / Facinelli, Diane (Thesis director) / Ryner, Bradley (Committee member) / TerBeek, Kendra (Committee member) / Barrett, The Honors College (Contributor) / Department of English (Contributor)
Created2013-05