Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 10 of 10
Description
This study was conducted to observe the effects of varying diets on weight regain after caloric restriction. Touted as a potentially effective non-invasive treatment to obesity, caloric restriction uses the gradual decrease in caloric intake to aid in weight loss. However, once a patient is taken off caloric restriction, a marked regain of weight regain occurs, nullifying the weight loss from caloric restriction. To find ways to suppress this weight regain, this study observed the effects of four different diets: low-fat diet (chow), high-fat diet (HFD), 0.5% concentration menthol infused chow, and 1% concentration menthol infused chow. Over a span of 3 years, 43 male Sprague-Dawley rats were placed through a strict feeding protocol: 3 weeks of chow food (3.1 kcal/gram), 8 or 12 weeks of HFD (5.42 kcal/gram), and caloric restriction for 4 weeks. Separate data analysis was conducted for the year 2017-2018, due to a slightly different protocol when compared to 2018-2019 and 2019-2020.
In 2017-2018, the results showed that 0.5% menthol (n=4) suppressed weight gain more effectively than both the baseline chow diet (n=4, p=0.022) and the HFD (n=4, p=0.027). Again in 2018-2020, the 0.5% menthol (n=6) showed promising results, showing significant suppression of weight gain when compared to chow (n=13, p=0.022). Unfortunately, the difference in weight gain in 1% menthol (n=6) was inconclusive when comparing to both chow and HFD. Although 1% menthol was inconclusive in its efficacy in suppressing weight regain, the promising results on 0.5% menthol show that menthol has the potential to be an effective treatment to both prevent rapid weight gain and maintain weight loss from caloric restriction.
In 2017-2018, the results showed that 0.5% menthol (n=4) suppressed weight gain more effectively than both the baseline chow diet (n=4, p=0.022) and the HFD (n=4, p=0.027). Again in 2018-2020, the 0.5% menthol (n=6) showed promising results, showing significant suppression of weight gain when compared to chow (n=13, p=0.022). Unfortunately, the difference in weight gain in 1% menthol (n=6) was inconclusive when comparing to both chow and HFD. Although 1% menthol was inconclusive in its efficacy in suppressing weight regain, the promising results on 0.5% menthol show that menthol has the potential to be an effective treatment to both prevent rapid weight gain and maintain weight loss from caloric restriction.
ContributorsLee, Justin (Author) / Van Horn, Wade (Thesis director) / Baluch, Debra (Committee member) / Herman, Richard (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Preliminary studies indicate that the use of dietary menthol may prevent excessive weight gain through the activation of the transient receptor potential melastatin family member 8 (TRPM8) ion channel. It has also been expressed that elevation of the core temperature (Tc) inducing mild hyperthermia via an increase in ambient temperature aids in a marked reduction of the drive to eat and weight gain. While caloric restriction (CR) aims to treat obesity and secondary sicknesses, weight regain is a common result during long term weight maintenance. The goal of these studies was to evaluate and identify if the menthol and mild hyperthermia mechanisms could couple synergistically to reduce or abrogate weight gain. Ambient temperature (Ta) was increased incrementally to identify the threshold in which rodents display mild hyperthermia. Our initial attempts at hyperthermia induction failed because of limitations in the environmental chamber. These trials fail to note a threshold at which elevated Tc is sustained for any period of time. The data suggests an ambient temperature of 36-38 °C would be appropriate to induce a mild hyperthermia. A mild hyperthermia is described as the elevation of Tc 2-3 ° above the hypothalamic set point. To facilitate future hyperthermia studies, an environmental chamber was designed. A wine cooler was converted to withstand the desired temperatures, through the use of heat tape, a proportional controller, and a translucent Plexiglas custom fit door. Beyond leveraging temperature to regulate weight gain, dietary changes including a comparison between standard chow food, high fat diet, and menthol supplemented chow food treatment illustrate a strong likelihood of weight gain variability. In this pilot study, weight gain expression when given a diet supplemented with menthol (1%) showed no statistical significance relative to a high fat diet nor chow food, however, it revealed a trend of reduced weight gain. It is assumed the combination of supplemental menthol and mild hyperthermia induction will exacerbate their effects.
ContributorsJohnsson, Kailin Alexis (Author) / Van Horn, Wade (Thesis director) / Herman, Richard (Committee member) / Towe, Bruce (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
"Company X," a technology company, is known for being one of the world’s largest semiconductor chip manufacturers; however, they are also one of the largest authors of software. In 2019, "Company X" entered a new paradigm where, according to the CEO, while "Company X"’s core strategy has not changed, "Company X" is embracing the transition to a data-centric company from a PC-centric company. The scope that the project examines is--in this transition to a data-centric company and based on the company's current expertise and competitive advantages--should "Company X" be branching into an additional division or leverage existing intellectual property (IP)? The goal of the project is to understand how "Company X" can leverage its expertise in hardware and software service packages to maximize the value of the company.
ContributorsArellano, Andrea (Co-author) / Roos, Bailey (Co-author) / Broas, Joshua (Co-author) / Kotti, Abhigyan (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Michael (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
I will begin my paper by briefly describing the background which led to this paper, as well as stating my thesis. Next, I will define the term terrorism and explain the difference between it and the associated terms of insurgency and guerrilla warfare. Further, I will briefly go over the history of terrorism and the methods employed by terrorist organizations. After this introductory element, I will proceed to explore how terrorism has been funded in the past and how it is being funded at present. Lastly, I will present an overview of future methods of financing and make a proposal as to how the United States and the rest of the world could possibly disrupt these forms of financing. This paper is not intended to be comprehensive in nature, as this would be too large in scope, but rather use specific examples to illustrate certain methods and uses of terrorist financing
ContributorsWonderly, Frank (Author) / Simonson, Mark (Thesis director) / Smith, Geoffrey (Committee member) / Department of Military Science (Contributor) / School of Accountancy (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Transient receptor potential (TRP) channels are a superfamily of ion channels found in plasma membranes of both single-celled and multicellular organisms. TRP channels all share the common aspect of having six transmembrane helices and a TRP domain. These structures tetramerize to form a receptor-activated non-selective ion channel. The specific protein being investigated in this thesis is the human transient receptor potential melastatin 8 (hTRPM8), a channel activated by the chemical ligand menthol and temperatures below 25 °C. TRPM8 is responsible for cold sensing and is related to pain relief associated with cooling compounds. TRPM8 has also been found to play a role in the regulation of various types of tumors. The structure of TRPM8 has been obtained through cryo-electron microscopy, but the functional contribution of individual portions of the protein to the overall protein function is unknown.
To gain more information about the function of the transmembrane region of hTRPM8, it was expressed in Escherichia coli (E. coli) and purified in detergent membrane mimics for experimentation. The construct contains the S4-S5 linker, pore domain (S5 and S6 transmembrane helices), pore helix, and TRP box. hTRPM8-PD+ was purified in the detergents n-Dodecyl-B-D-Maltoside (DDM), 16:0 Lyso PG, 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoglycerol (LPPG), and 14:0 Lyso PG, 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoglycerol (LMPG) to determine which detergent resulted in a hTRPM8-PD+ sample of the most stability, purity, and highest concentrations. Following bacterial expression and protein purification, hTRPM8-PD+ was studied and characterized with circular dichroism (CD) spectroscopy to learn more about the secondary structures and thermodynamic properties of the construct. Further studies can be done with more circular dichroism (CD) spectroscopy, planar lipid bilayer (BLM) electrophysiology, and nuclear magnetic resonance spectroscopy (NMR) to gain more understanding of how the pore domain plus contributes to the activity of the whole protein construct.
To gain more information about the function of the transmembrane region of hTRPM8, it was expressed in Escherichia coli (E. coli) and purified in detergent membrane mimics for experimentation. The construct contains the S4-S5 linker, pore domain (S5 and S6 transmembrane helices), pore helix, and TRP box. hTRPM8-PD+ was purified in the detergents n-Dodecyl-B-D-Maltoside (DDM), 16:0 Lyso PG, 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoglycerol (LPPG), and 14:0 Lyso PG, 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoglycerol (LMPG) to determine which detergent resulted in a hTRPM8-PD+ sample of the most stability, purity, and highest concentrations. Following bacterial expression and protein purification, hTRPM8-PD+ was studied and characterized with circular dichroism (CD) spectroscopy to learn more about the secondary structures and thermodynamic properties of the construct. Further studies can be done with more circular dichroism (CD) spectroscopy, planar lipid bilayer (BLM) electrophysiology, and nuclear magnetic resonance spectroscopy (NMR) to gain more understanding of how the pore domain plus contributes to the activity of the whole protein construct.
ContributorsMorelan, Danielle Taylor (Co-author) / Morelan, Danielle (Co-author) / Van Horn, Wade (Thesis director) / Chen, Julian (Committee member) / Luu, Dustin (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
Description
Opening a business is often an exciting time in one’s life, as they take their business idea into the marketplace. But, most individuals fail to adequately address whether their business can actually succeed before entering the marketplace. The thesis, Creating a Successful Gluten-Free Bakery: A Financial Model and Analysis analyzes whether or not a gluten-free bakery is a viable business to open in today’s marketplace. By costing the main financial variables, creating a financial model of a gluten-free bakery, and running scenario analysis, I was able to find whether or not opening a gluten-free bakery was a viable business in today’s marketplace.
ContributorsDantonio, Adam (Author) / Simonson, Mark (Thesis director) / Arthur, Budolfson (Committee member) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
Description
By 2030, annual global automobile production is projected to reach over 110 million vehicles with an increasing quantity having autonomous capabilities. Based on this trend, Company X is poised to drive profits by leveraging advancing technology from their subsidiary to gain significant market share within the AV industry. This will solidify Company X’s position as a key player and leader within the AV industry, which is expected to grow to $7 trillion by 2050, and Company X can achieve this by providing a technology suite including a systems on a chip to auto manufacturers and creating partnerships in the technology and automotive industry.
ContributorsAvery, Hailey (Co-author) / Green, Ryan (Co-author) / Hall, Robert (Co-author) / Hummel, Haley (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Michael (Committee member) / Department of Finance (Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This thesis discusses the case for Company X to improve its vast supply chain by implementing an artificial intelligence solution in the management of its spare parts inventory for manufacturing-related machinery. Currently, the company utilizes an inventory management system, based on previously set minimum and maximum thresholds, that doesn’t use predictive analytics to stock required spares inventory. This results in unnecessary costs and redundancies within the supply chain resulting in the stockout of spare parts required to repair machinery. Our research aimed to quantify the cost of these stockouts, and ultimately propose a solution to mitigate them. Through discussion with Company X, our findings led us to recommend the use of Artificial Intelligence (A.I.) within the inventory management system to better predict when stockouts would occur. As a result of data availability, our analysis began on a smaller scale, considering only a single manufacturing site at Company X. Later, our findings were extrapolated across all manufacturing sites. The analysis includes the cost of stockouts, the capital that would be saved with A.I. implementation, costs to implement this new A.I. software, and the final net present value (NPV) that Company X could expect in 10 years and 25 years. The NPV calculations explored two scenarios, an external partnership and the purchase of a small private company, that lead to our final recommendations regarding the implementation of an A.I. software solution in Company X’s spares inventory management system. Following the analysis, a qualitative discussion of the potential risks and market opportunities associated with the explored implementation scenarios further guided the determination of our final recommendations.
ContributorsHolohan, Joseph Michael Houston (Co-author) / Shahriari, Rosie (Co-author) / Aun, Jose (Co-author) / Heineke, Christopher (Co-author) / Gurrola, Macario (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Michael (Committee member) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This thesis investigates the use of MS Power BI in the case company’s heterogeneous computing environment. The empirical evidence was collected through the authors’ own observations and exposure to the modeling of dashboards, other supported external findings from interviews, published articles, academic journals, and speaking with leading experts at the WA ‘Dynamic Talks Seattle/Redmond: Big Data Analytics’ conference. Power BI modeling is effective for advancing the development of statistical thinking and data retrieving skills, finding trends and patterns in data representations, and making predictions. Computer-based data modeling gave meaning to math results, and supported examining implications of these results with simple charts to improve perception. Querying and other add-ins that would be seen as affordances when using other BI softwares, with some complexity removed in Power BI, make modeling data an easier undertaking for report builders. Using computer-based qualitative data analysis software, this paper details opportunities and challenges of data modeling with dashboards. Simple linear regression is used for case study use only.
ContributorsKusen, Alexandra Jeshua (Co-author) / Briones, Jared (Co-author) / Fugleberg, Aaron (Co-author) / Lin, Amy (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Michael (Committee member) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Transient receptor potential (TRP) channels are a diverse family of polymodally gated nonselective cation channels implicated in a variety of pathophysiologies. Two channels of specific interest are transient receptor potential melastatin 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1).
TRPM8 is the primary cold sensor in humans and is activated by ligands that feel cool such as menthol and icilin. It is implicated to be involved in a variety of cancers, nociception, obesity, addiction, and thermosensitivity. There are thought to be conserved regions of structural and functional importance to the channel which can be identified by looking at the evolution of TRPM8 over time. Along with this, looking at different isoforms of TRPM8 which are structurally very different but functionally similar can help isolate regions of functional interest as well. Between TRP channels, the transmembrane domain is well conserved and thought to be important for sensory physiology. To learn about these aspects of TRPM8, three evolutionary constructs, the last common primate, the last common mammalian, and the last common vertebrate ancestor TRPM8 were cloned and subjected to preliminary studies. In addition to the initial ancestral TRPM8 studies, fundamental studies were initiated in method development to evaluate the use of biological signaling sequences to attempt to force non-trafficking membrane protein isoforms and biophysical constructs to the plasma membrane. To increase readout for these and other studies, a cellular based fluorescence assay was initiated. Eventual completion of these efforts will lead to better understanding of the mechanism that underlie TRPM8 function and provide enhanced general methods for ion channel studies.
Beyond TRPM8 studies, an experiment was designed to probe mechanistic features of TRPV1 ligand activation. TRPV1 is also a thermosensitive channel in the TRP family, sensing heat and vanilloid ligands like capsaicin, commonly found in chili peppers. This channel is also involved in many proinflammatory interactions and associated with cancers, nociception, and addiction. Better understanding binding interactions can lead to attempts to create therapeutics.
TRPM8 is the primary cold sensor in humans and is activated by ligands that feel cool such as menthol and icilin. It is implicated to be involved in a variety of cancers, nociception, obesity, addiction, and thermosensitivity. There are thought to be conserved regions of structural and functional importance to the channel which can be identified by looking at the evolution of TRPM8 over time. Along with this, looking at different isoforms of TRPM8 which are structurally very different but functionally similar can help isolate regions of functional interest as well. Between TRP channels, the transmembrane domain is well conserved and thought to be important for sensory physiology. To learn about these aspects of TRPM8, three evolutionary constructs, the last common primate, the last common mammalian, and the last common vertebrate ancestor TRPM8 were cloned and subjected to preliminary studies. In addition to the initial ancestral TRPM8 studies, fundamental studies were initiated in method development to evaluate the use of biological signaling sequences to attempt to force non-trafficking membrane protein isoforms and biophysical constructs to the plasma membrane. To increase readout for these and other studies, a cellular based fluorescence assay was initiated. Eventual completion of these efforts will lead to better understanding of the mechanism that underlie TRPM8 function and provide enhanced general methods for ion channel studies.
Beyond TRPM8 studies, an experiment was designed to probe mechanistic features of TRPV1 ligand activation. TRPV1 is also a thermosensitive channel in the TRP family, sensing heat and vanilloid ligands like capsaicin, commonly found in chili peppers. This channel is also involved in many proinflammatory interactions and associated with cancers, nociception, and addiction. Better understanding binding interactions can lead to attempts to create therapeutics.
ContributorsShah, Karan (Author) / Van Horn, Wade (Thesis director) / Neisewander, Janet (Committee member) / Biegasiewicz, Kyle (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of Molecular Sciences (Contributor, Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05