Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 6 of 6
Description
Enzyme Replacement Therapy (ERT) is a treatment often used for patients with disorders that affect the production of various enzymes within the body, such as Cystic Fibrosis and Fabry Disease. ERT involves the use of artificially-produced enzymes, which can be derived from humans, pigs, and bacteria. Generally, enzymes derived from porcine and bacterial sources are much less expensive and more accessible than those derived from a human source. This, and the ethical implications that porcine enzymes carry, make the decision of choosing treatment simple to some and complex to others. Ethically, human-derived enzymes are often considered more ethical, while not conflicting with religious beliefs and practices as porcine-derived enzymes do.
In order to further compare porcine and human-derived enzymes, a determination of the enzyme effectiveness was done via digestion simulation. The digestion for both the human and porcine-derived enzymes consisted of three steps: oral, gastric, and intestinal. After the digestion, the absorbance for each enzyme class as well as a dilution curve of the formula used was read and recorded. Using the standard dilution curve and the absorbance values for each unknown, the formula and thus enzyme concentration that was lost through the reaction was able to be calculated.
The effectiveness of both the human and porcine enzymes, determined by the percent of formula lost, was 18.2% and 19.7%, respectively, with an error of 0.6% from the spectrophotometer, and an error of about 10% from the scale used for measuring the enzymes. This error was likely due to the small mass required of the enzymes and can be prevented in the future by performing the experiment at a larger scale.
In order to further compare porcine and human-derived enzymes, a determination of the enzyme effectiveness was done via digestion simulation. The digestion for both the human and porcine-derived enzymes consisted of three steps: oral, gastric, and intestinal. After the digestion, the absorbance for each enzyme class as well as a dilution curve of the formula used was read and recorded. Using the standard dilution curve and the absorbance values for each unknown, the formula and thus enzyme concentration that was lost through the reaction was able to be calculated.
The effectiveness of both the human and porcine enzymes, determined by the percent of formula lost, was 18.2% and 19.7%, respectively, with an error of 0.6% from the spectrophotometer, and an error of about 10% from the scale used for measuring the enzymes. This error was likely due to the small mass required of the enzymes and can be prevented in the future by performing the experiment at a larger scale.
ContributorsBlevins, Brianna R (Author) / Martin, Thomas (Thesis director) / McILwraith, Heide (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Abstract:
As Barrett Polytechnic moves into the final stages of planning for the new residential hall, currently under construction on the Polytechnic campus, it is important that they have the student voice in mind when making final decisions. Past research has shown that students who live on campus have a higher retention rate not only through their first year, but onto graduation. Research has also found that students who live on campus become more involved in the community and use more of the university’s resources. Seeing that Barrett prides itself on being a community of scholars, proper use of student feedback should be used to prepare the new building for its students. Data was collected via a survey and focus group, focused primarily on what the students would like to see in their new space. Once collected and analyzed it was apparent that students were really concerned with a few aspects of the new residential building and lounge space.
Using the analyzed data, the following recommendations were made:
1. Reevaluation of the student residential experience after the move to the new residential building.
2. Revaluation of accessibility to the mentorship opportunities after the move to the residential building, as well as an increased movement by Barrett to foster these relationships
3. Addition of quantity of computers as well as newer technology, addition of whiteboards and charging stations, and ensuring there is proper group and individual workstations.
4. Consideration of what students use the lounge for and how to best set up the space for those uses.
5. More advertisement of the Barrett Polytechnic library as well as an more research to determine whether or not improving the library would encourage more use.
6. Make steps to keep the lounge open later in the evenings as well as ensuring students, both on and off campus, have access to the lounge amenities when they need them most.
As Barrett Polytechnic moves into the final stages of planning for the new residential hall, currently under construction on the Polytechnic campus, it is important that they have the student voice in mind when making final decisions. Past research has shown that students who live on campus have a higher retention rate not only through their first year, but onto graduation. Research has also found that students who live on campus become more involved in the community and use more of the university’s resources. Seeing that Barrett prides itself on being a community of scholars, proper use of student feedback should be used to prepare the new building for its students. Data was collected via a survey and focus group, focused primarily on what the students would like to see in their new space. Once collected and analyzed it was apparent that students were really concerned with a few aspects of the new residential building and lounge space.
Using the analyzed data, the following recommendations were made:
1. Reevaluation of the student residential experience after the move to the new residential building.
2. Revaluation of accessibility to the mentorship opportunities after the move to the residential building, as well as an increased movement by Barrett to foster these relationships
3. Addition of quantity of computers as well as newer technology, addition of whiteboards and charging stations, and ensuring there is proper group and individual workstations.
4. Consideration of what students use the lounge for and how to best set up the space for those uses.
5. More advertisement of the Barrett Polytechnic library as well as an more research to determine whether or not improving the library would encourage more use.
6. Make steps to keep the lounge open later in the evenings as well as ensuring students, both on and off campus, have access to the lounge amenities when they need them most.
ContributorsHorn, Kyle Edward (Co-author, Co-author) / Martin, Thomas (Thesis director) / Brady, Jennifer (Committee member) / Sever, Amy (Committee member) / Aviation Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The United Nations outlined seventeen goals in their 2015 resolution aimed at securing a more sustainable future for the entire world. These goals cover all parts of life and are meant to standardize quality of life at a high level for all countries. Specific to the Maasai people of Kenya and Tanzania, there are five main goals that would tackle some of the biggest issues facing the Maasai and greatly improve their lives. These goals include the promotion of good health and well-being, ensuring a quality education for school-age children, supporting efforts for gender equality in all communities, and securing clean and safe water and sanitation services for all people around the world. There are many Non-Governmental Organizations (NGOs) in the Maasai community that are striving to support them and realize these Sustainable Development Goals. Organizations like the Maasai Girls Education Fund and Aid Tanzania have established educational programs to support children, mainly girls, in their efforts to get an education. Others like End Water Poverty and the Maasai Association have programs to ensure safe, accessible drinking water is made available to Maasai communities across Kenya and Tanzania. Lastly, NGOs like My Chosen Vessels have programs that support the economic sustainability and livestock management of the Maasai while also ensuring that Maasai families receive clean water and access to an education. The work and practices of NGOs like these can serve as examples of how to efficiently and effectively address and tackle issues in developing countries, specifically regarding Maasai women and girls, to move closer to achieving these UN Sustainable Development Goals and lead a more sustainable future. Many studies have been done researching the political and economic struggles for Maasai communities and how it impacts them. Vandana Shiva coined the term, “Water Democracy” in her book Water Wars to express the multiple reasons why water is a necessity and right. Many Maasai groups do not have easy access to basic essentials for their everyday lives and NGOs have been noticing this more and more. Dorothy Hodgson writes about the history of Maasai NGOs, and mentions the multiple conflicts that they have had with each other, causing many Maasai groups to have different lifestyles. The connections between the history of the Maasai tribe, their current economy and their current relationship with the government and NGOs all impact women in their communities in different ways.
ContributorsWacloff, Jianna K (Author) / Martin, Thomas (Thesis director) / Oberle, Eric (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
In this paper, I describe the development of a unique approach to developing strategies for games in which success can only be measured by the final outcome of the game, preventing the use of heuristics. I created and evaluated evolutionary algorithms, applying them to develop strategies for tic-tac-toe. Strategies are comprised of neural networks with randomly initiated weights. A population of candidate strategies are created, each strategy competes individually against each other strategy, and evolutionary operators are applied to create subsequent generations of strategies. The set of strategies within a generation of the evolutionary algorithm forms a metagame that evolves as the algorithm progresses. Hypothesis testing shows that strategies produced by this approach significantly outperform a baseline of entirely random action, although they are still far from optimal gameplay.
ContributorsRodriguez, Julien Guillermo (Author) / Martin, Thomas (Thesis director) / Powers, Brian (Committee member) / College of Integrative Sciences and Arts (Contributor, Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The United States has an institutional prison system built on the principle of retributive justice combined with racial prejudice that despite countless efforts for reform currently holds 2.3 million individuals, primarily minorities, behind bars. This institution has remained largely unchanged, meanwhile 83.4% of those who enter the system will return within one decade and it currently costs nearly $39 billion each year (Alper 4). Because the prison institution consistently fails to address the core root of crime, there is a great need to reconsider the approach taken towards those who break our nation’s laws with the dual purpose of enhancing freedom and reducing crime. This paper outlines an original theoretical framework being implemented by Project Resolve that can help to identify and implement solutions for our prison system without reliance on political, institutional, or societal approval. The method focuses on three core goals, the first is to connect as much of the data surrounding prisoners and the formerly incarcerated as possible, the second is to use modern analytic approaches to analyze and propose superior solutions for rehabilitation, the third is shifting focus to public interest technology both inside prisons and the parole process. The combination of these objectives has the potential to reduce recidivism to significantly, deter criminals before initial offense, and to implement a truly equitable prison institution.
ContributorsGilchrist, Troy (Author) / Martin, Thomas (Thesis director) / Wenrick, Lukas (Committee member) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The aim of this project was to conduct an investigation of the cosmetic industry, particularly the field encompassing Botox and dermal fillers. The research helped to identify the various types of fillers used in the market as well as to explore the potential advantages of mechanical injectors within the field. This research and an industry analysis was further used to investigate the necessary components that would best accommodate the patent for a mechanical hand-held injector for the injection of dermal fillers.
ContributorsJames, Merine (Author) / Martin, Thomas (Thesis director) / Devine, John (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05