Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- Creators: School of Life Sciences
- Creators: O'Flaherty, Katherine
Description
The Beauty Within is a ceramics show displaying human body anatomy, which seeks to bridge aspects of my biological sciences major in the School of Life Sciences with aspects of my studio art minor in the Herberger Institute for Design and the Arts. My goal in creating the show was to change the opinion of people on human body organs from unease to admiration by recreating these organs in an artistic light. By stylizing the construction of the pieces and bringing in the contemporary form of art \u2014 makeup art \u2014 I hoped to bring a new light to the pieces and highlight the beauty within the human body. By leaving the pieces partly unfinished I further hoped to draw attention to the natural beauty within the pieces regardless of the makeup that covers them. By holding the show in the human anatomy lab room on campus and having both animal and human organs on display I was able to create that sense of disgust toward the organs in the viewers. The beauty of my created pieces was then directly contrasted with the disgust felt about the real organs by displaying each of my pieces next to a real organ. The reactions of the viewers reflected a change in view from the actual organs to my re-created organs, and therefore the goal of the show was achieved.
ContributorsThomas, Brandon Lee (Author) / Weiser, Kurt (Thesis director) / Chung, Samuel (Committee member) / School of Art (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This thesis project examines the likely factors that cause students to drop out of Barrett, the Honors College. Honors literature regarding retention and attrition suggests four areas encompassing individual student attributes and honors program characteristics which may impact a student's decision to stay or leave an Honors College. The primary question in focus is, "Why do students leave the Honors College?" followed by the tertiary questions of, "what can be done to mitigate this occurrence?" and, "how does this affect the quality of an honors education?" Assessing attrition can be broken down into biographical, cognitive-behavioral, socio-environmental, and institutional-instrumental components. Students who graduated with honors and those who did not graduate with honors were assessed on these four components through survey methods and qualitative interviews to investigate specific reasons why students leave the honors program. The results indicated a wide array of reasons impacting student attrition, the most significant being negative perceptions towards (1) honors courses and contracts, (2) difficulty completing a thesis project, and (3) finding little to no value in "graduating with honors." Each of these reasons reflect the institutional-instrumental component of student attrition, making it the most salient group of reasons why students leave the Honors College. The socio-environmental component also influences student attrition through peer influence and academic advisor support, though this was found to be within the context of institutional-instrumental means. This project offers solutions to ameliorate each of the four components of attrition by offering standardized honors contracts and more mandatory honors classes, mandatory thesis preparatory courses instead of workshops, and emphasizing the benefit Barrett gives to students as a whole. These solutions aim at increasing graduation rates for future honors students at Barrett as well as improving the overall quality of an honors education.
ContributorsSanchez, Gilbert Xavier (Author) / Parker, John (Thesis director) / O'Flaherty, Katherine (Committee member) / School of Criminology and Criminal Justice (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The Mexican gray wolf (Canis lupus baileyi) is a genetically distinct subspecies of the gray wolf (Canis lupus) that was driven to the brink of extinction as a result of human persecution. The wolf is listed as Endangered under the Endangered Species Act, and a recovery program is underway in Arizona and New Mexico to restore its population. However, the wolf is struggling to recover due to high mortality, which is a result of continued human hostility toward it. This thesis examines historical and current human attitudes toward the wolf and the implications that they have had on the extermination and recovery of the subspecies. An overview is given of wolf biology, the history of wolf extermination and recovery, and recent events relating to the recovery of the wolf. Negative impacts on ranching, hunting, and human safety are the main reasons for opposition toward wolves and wolf recovery; these concerns are analyzed, and solutions to them are proposed, with the goal of addressing them while fostering non-lethal coexistence with the wolf. In addition, opposition to wolves and wolf recovery is tied in with larger socio-political issues and is influenced by the representation of the wolf in culture; these issues in the context of wolves are also analyzed.
ContributorsLenk, Heather Nicole (Author) / Smith, Andrew (Thesis director) / Minteer, Ben (Committee member) / Brown, David E. (Committee member) / School of Life Sciences (Contributor) / School of Sustainability (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Limited research has analyzed how culture might influence the utilization of social support. To address this deficiency, the present study investigated preferences for social support among East-Asian, Hispanic, and White participants. In this set of studies, a comprehensive social support taxonomy was constructed in order to better identify and conceptualize the various support subtypes found in the literature. Based on the taxonomy, a questionnaire measure for preferences of different types of social support was developed. Participants were asked to rate how helpful they would find each supportive action made by a friend or family member on a seven-point Likert scale. Based on the responses of 516 Amazon Mechanical Turk workers, a five-factor solution for an 18-item scale emerged from a factor analysis. The social support subscales supported by the factor analysis were emotional, tangible, self-referencing, reappraisal, and distraction. The questionnaire was used to assess similarities and differences among East-Asian, Hispanic, and White participants in terms of preferences for providing and receiving social support. Based on the results of 299 college-age students, an analysis of variance on individually standardized ("ipsatized") responses was conducted in order to eliminate the positioning effect of culture. A main effect of ethnicity (p=.05) and an interaction between ethnicity and sex (p=.02) were significant for the preference of tangible social support. A main effect of ethnicity (p=.04) and an interaction between ethnicity and sex (p=.05) were significant for the preference of reappraisal social support. Clinical implications of our research findings are discussed.
ContributorsCampagna, Allegra Xiu Hong (Author) / Shiota, Michelle N. (Thesis director) / Campos, Belinda (Committee member) / Yee, Claire (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Undergraduate on-campus residential education is a topic of significant inquiry within the field of higher education, and specifically student affairs. It has become commonplace for institutions of higher education in the United States to leverage the intersections between academics and residence life in order to promote student success by offering on-campus housing options that strategically place students in residential communities that provide additional connection to the students' academic experience, often by major, college, department, or other focus areas. Such models vary by institution, but are often referred to as living-learning communities or residential colleges, depending upon their structure and goals. For example, Barrett, the Honors College on the Tempe campus of Arizona State University implements a residential college model within its student housing; honors students live and study together, with the addition of three "special communities" designed for students majoring in Engineering, Business, or the Arts. This honors thesis case study describes and investigates the impact the visual and performing arts Barrett residential community has upon its residents in their first-year college experience. Through the lens of student development theory, this research focuses upon examining this specific residential community in detail in order to gain an understanding of its effect upon residents' academic and personal well being.
ContributorsBieschke, Sara Danielle (Author) / O'Flaherty, Katherine (Thesis director) / Rendell, Dawn (Committee member) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Type II diabetes is a serious, chronic metabolic disease that has serious impacts on both the health and quality of life in patients diagnosed with the disease. Type II diabetes is also a very prevalent disease both in the United States and around the world. There is still a lot that is unknown about Type II diabetes, and this study will aim to answer some of these questions. The question posed in this study is whether insulin resistance changes as a function of time after the start of a high fat diet. We hypothesized that peripheral insulin resistance would be observed in animals placed on a high fat diet; and peripheral insulin resistance would have a positive correlation with time. In order to test the hypotheses, four Sprague-Dawley male rats were placed on a high fat diet for 8 weeks, during which time they were subjected to three intraperitonal insulin tolerance tests ((NovoLogTM 1 U/kg). These three tests were conducted at baseline (week 1), week 4, and week 8 of the high fat diet. The test consisted of serially determining plasma glucose levels via a pin prick methodology, and exposing a droplet of blood to the test strip of a glucometer (ACCUCHEKTM, Roche Diagnostics). Two plasma glucose baselines were taken, and then every 15 minutes following insulin injection for one hour. Glucose disposal rates were then calculated by simply dividing the glucose levels at each time point by the baseline value, and multiplying by 100. Area under the curve data was calculated via definite integral. The area under the curve data was then subjected to a single analysis of variance (ANOVA), with a statistical significance threshold of p<0.05. The results of the study did not indicate the development of peripheral insulin resistance in the animals placed on a high fat diet. Insulin-mediated glucose disposal was about 50% at 30 minutes in all four animals, during all three testing periods. Furthermore, the ANOVA resulted in p=0.92, meaning that the data was not statistically significant. In conclusion, peripheral insulin resistance was not observed in the animals, meaning no determination could be made on the relation between time and insulin resistance.
ContributorsBrown, Kellen Andrew (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
the project led by Professor Emma Frow, researching of stem cell clinics focused on stem cell applications, adherence to FDA guidelines, and characterization of information available and physician credentials. Regenerative medicine clinics commonly offered stem cell therapy, but introduced platelet rich plasma (PRP) and prolotherapy as regenerative therapies.
PRP and Prolotherapy are individual treatments that were even suggested and used in combination with stem cell therapies. Prolotherapy predates PRP as a chemical irritant therapy originally used to sclerose tissues. Prolotherapy is meant to stimulate platelet derived growth factors release to improve tissue healing response. Prolotherapy shows negligible efficacy improvements over corticosteroids, but may have underlying side effects from being an irritant. PRP is a more modern therapy for improved healing. Speculations state initial use was in an open heart surgery to improve healing post-surgery. PRP is created via centrifugation of patient blood to isolate growth factors by removing serum and other biological components to increase platelet concentration. PRP is comparable to corticosteroid injections in efficacy, but as an autologous application, there are no side effects making it more advantageous. Growth factors induce healing response and reduce inflammation. Growth factors stimulate cell growth, proliferation, differentiation, and stimulate cellular response mechanism such as angiogenesis and mitogenesis. The growth factor stimulation of PRP and prolotherapy both assist stem cell proliferation. Additional research is needed to determine differential capacity to ensure multipotent stem cells regenerate the correct cell type from the increased differential capacity offered by growth factor recruitment. The application of combination therapy for stem cells is unsubstantiated and applications violate FDA ‘minimal manipulation’ guidelines.
PRP and Prolotherapy are individual treatments that were even suggested and used in combination with stem cell therapies. Prolotherapy predates PRP as a chemical irritant therapy originally used to sclerose tissues. Prolotherapy is meant to stimulate platelet derived growth factors release to improve tissue healing response. Prolotherapy shows negligible efficacy improvements over corticosteroids, but may have underlying side effects from being an irritant. PRP is a more modern therapy for improved healing. Speculations state initial use was in an open heart surgery to improve healing post-surgery. PRP is created via centrifugation of patient blood to isolate growth factors by removing serum and other biological components to increase platelet concentration. PRP is comparable to corticosteroid injections in efficacy, but as an autologous application, there are no side effects making it more advantageous. Growth factors induce healing response and reduce inflammation. Growth factors stimulate cell growth, proliferation, differentiation, and stimulate cellular response mechanism such as angiogenesis and mitogenesis. The growth factor stimulation of PRP and prolotherapy both assist stem cell proliferation. Additional research is needed to determine differential capacity to ensure multipotent stem cells regenerate the correct cell type from the increased differential capacity offered by growth factor recruitment. The application of combination therapy for stem cells is unsubstantiated and applications violate FDA ‘minimal manipulation’ guidelines.
ContributorsKrum, Logan (Author) / Frow, Emma (Thesis director) / Brafman, David (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Advancements in science and technology, particularly in the field of genome editing, hold significant potential to change how future generations will treat disease and may fundamentally change what it means to be human. There are concerns by scientists and non-scientists about how to explore the values and perceptions of the public regarding the implications of new technologies. Use of participatory Technology Assessment (pTA) has arisen as a type of interactive group discussion to disseminate information about technology and collect non-scientists' perceptions of the value, impact or usefulness of a technology and potential ethical issues or consequences to be considered. There is no one size fits all model of pTA; several are discussed in this paper, but there are similarities between them such as the structure of engagement or recruitment criteria. It is important to note a difference in public understanding of science and public engagement with science as it relates to the structure and execution of pTA. This study was undertaken to evaluate pTA as a tool to explore perceptions, values and opinions regarding a case study of CRISPR-Cas9, a tool for genome editing, among ASU Barrett undergraduate students.
ContributorsChapin, Natalie Ann (Author) / Brian, Jennifer (Thesis director) / Bennett, Ira (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the deterioration of motor neurons. ALS affects about 1 in 20,000 people and leads to death within 2 to 5 years after diagnosis. There is currently no cure for ALS, but there are many genes known to be associated with ALS, such as SOD 1 and C9orf72. Recently, mutations in Matrin 3 were linked to ALS. While 15 mutations in Matrin 3 have been discovered, this study focuses on the four initial mutations, which are the Ser85Cys, Phe115Cys, Pro154Ser, and Thr622Ala mutations. This study attempts to understand the mechanism of how these mutations lead to ALS. The first aim focuses on the role of Matrin mutations in the mislocalization of TDP-43 from the nucleus to the cytoplasm, a pathological hallmark of ALS. We hypothesized expression of mutant Matrin 3 would lead to TDP-43 mislocalization, however the data did not support that hypothesis. The second aim of this study focuses on the mislocalization of TRanscription EXport (TREX) complex proteins within the nucleus. TREX proteins were studied based off of previous experiments suggesting that proteins within this complex bind to Matrin 3. The results showed differences in co-localization between each of these proteins and wild-type and mutant Matrin 3, confirming our earlier results. These findings can help increase our understanding of the mechanism of ALS while also setting the framework for future studies.
ContributorsSingh, Gurkaran (Author) / Bowser, Robert (Thesis director) / Newbern, Jason (Committee member) / Boehringer, Ashley (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Valley Fever, also known as coccidioidomycosis, is a respiratory disease that affects 10,000 people annually, primarily in Arizona and California. Due to a lack of gene annotation, diagnosis and treatment of Valley Fever is severely limited. In turn, gene annotation efforts are also hampered by incomplete genome sequencing. We intend to use proteogenomic analysis to reannotate the Coccidioides posadasii str. Silveira genome from protein-level data. Protein samples extracted from both phases of Silveira were fragmented into peptides, sequenced, and compared against databases of known and predicted proteins sequences, as well as a de novo six-frame translation of the genome. 288 unique peptides were located that did not match a known Silveira annotation, and of those 169 were associated with another Coccidioides strain. Additionally, 17 peptides were found at the boundary of, or outside of, the current gene annotation comprising four distinct clusters. For one of these clusters, we were able to calculate a lower bound and an estimate for the size of the gap between two Silveira contigs using the Coccidioides immitis RS transcript associated with that cluster's peptides \u2014 these predictions were consistent with the current annotation's scaffold structure. Three peptides were associated with an actively translated transposon, and a putative active site was located within an intact LTR retrotransposon. We note that gene annotation is necessarily hindered by the quality and level of detail in prior genome sequencing efforts, and recommend that future studies involving reannotation include additional sequencing as well as gene annotation via proteogenomics or other methods.
ContributorsSherrard, Andrew (Author) / Lake, Douglas (Thesis director) / Grys, Thomas (Committee member) / Mitchell, Natalie (Committee member) / Computing and Informatics Program (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12