Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

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Immunotherapy uses the body’s immune system to find and terminate cancerous cells, and has revolutionized cancer treatment. However, in certain cancers, such as lung cancer, less than 50% of patients respond to treatment. This is in part due to the immunosuppressive tumor microenvironment, which is composed of factors that promote

Immunotherapy uses the body’s immune system to find and terminate cancerous cells, and has revolutionized cancer treatment. However, in certain cancers, such as lung cancer, less than 50% of patients respond to treatment. This is in part due to the immunosuppressive tumor microenvironment, which is composed of factors that promote tumor growth and proliferation. Tumor cells create a highly immunosuppressive microenvironment by triggering the anti-inflammatory phenotype of myeloid immune cells, which largely consist of tumor-associated macrophages (TAMs). Anti-PD-1 and anti-PD-L1 immune checkpoint blockade therapy helps promote the T cell anti-tumor response by releasing the brakes on cytotoxic T-cells. However, it is unclear how TAMs respond to these immune checkpoint antibodies. Our lab hypothesizes that blockade of the PD-1/PD-L1 signaling pathway drives a pro-inflammatory macrophage phenotype. This hypothesis is supported by data generated in the B16F10 murine melanoma model, but it is unknown whether macrophage response to PD-L1 blockade is generalizable to other tumor contexts. Thus, the goal of the project is to determine the impact of immune checkpoint blockade on murine macrophages in the Lewis Lung Carcinoma (LLC) model. Using Flow Cytometry, macrophage phenotypes will be analyzed to confirm whether a pro- inflammatory or anti-tumor response is generated.
ContributorsKorpe, Sara (Author) / Cadillo-Quiroz, Hinsby (Thesis director) / Lancaster, Jessica (Committee member) / Barrett, The Honors College (Contributor) / Economics Program in CLAS (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
This paper analyzes the factors that contribute to suicide using current literature, statistics, and research towards what affects suicidal tendencies. It was found that there are 5 main factors that contribute towards these tendencies: economics, social factors, geography, politics, and biology. Additionally, some of these factors included subcategories of factors

This paper analyzes the factors that contribute to suicide using current literature, statistics, and research towards what affects suicidal tendencies. It was found that there are 5 main factors that contribute towards these tendencies: economics, social factors, geography, politics, and biology. Additionally, some of these factors included subcategories of factors and/or were connected to the other factors mentioned. It was concluded that there is not just one factor that may contribute to someone taking their own life, however a combination of different factors that may influence suicidal tendencies.
ContributorsGeorge, Rhys (Author) / O'Flaherty, Katherine (Thesis director) / Hurtado, Ana (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2024-05
Description

This project aimed to understand what best practices for leadership in the Information Technology sector and if it could be consolidated for a comprehensive learning plan. This learning plan was housed on a traditional LMS (Canvas) and utilized a combination of IT Management research, interviews conducted with five industry members

This project aimed to understand what best practices for leadership in the Information Technology sector and if it could be consolidated for a comprehensive learning plan. This learning plan was housed on a traditional LMS (Canvas) and utilized a combination of IT Management research, interviews conducted with five industry members (all boasting five or more years of work experience), and an analysis of six top institution IT Leadership programs, to create a template. For the provided questionnaires, participants were asked to consider their time in the industry and discuss work culture dynamics, distribution of power, and what pain points were felt in their daily operations. All participants also described their direct roles and seniority, ranging from self-described “middle” to ”high” level placements. Based on these interviews, much of what seems to halt productivity and employee satisfaction regularly comes from a lack of concise and regular communication and a need for more understanding regarding team members' drive or capabilities. Regarding the program evaluation, six IT Leadership programs were chosen, where five were constructed by higher education institutions and one from a certificate governing body. The top skills identified across all programs were communication and decision-making. Communication is an all-encompassing idea for collaboration and strong speaking skills, with programs 1,4,5, and 6 noting their importance. Decision-making in this context is about both work delegation and firm problem-solving. For work delegation, it was pointed out in the interviews that techs and engineers see strong leadership utilizing professional judgment as vital to a business’s performance, with all programs but program 4 similarly emphasizing the same. Given this evaluation, the leadership styles used can be identified as Delegative, Strengths-Based, and Transformative. The previously noted interviews and research resulted in a 4-week course demo, which utilized the interviews in conjunction with leadership concepts.

ContributorsOrtiz Leon, David (Author) / O'Flaherty, Katherine (Thesis director) / Rouse, Nick (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor)
Created2023-12
ContributorsOrtiz Leon, David (Author) / O'Flaherty, Katherine (Thesis director) / Rouse, Nick (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor)
Created2023-12
ContributorsOrtiz Leon, David (Author) / O'Flaherty, Katherine (Thesis director) / Rouse, Nick (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor)
Created2023-12
Description
The objective of this meta-analysis is to holistically evaluate the existing body of literature on the anti-neoplastic potential of snake and bee venom. In recent years, venom-based therapeutics have emerged as a promising solution for combating cancer, generating a notable rise in publications on the topic. Consequently, this comprehensive study

The objective of this meta-analysis is to holistically evaluate the existing body of literature on the anti-neoplastic potential of snake and bee venom. In recent years, venom-based therapeutics have emerged as a promising solution for combating cancer, generating a notable rise in publications on the topic. Consequently, this comprehensive study aims to assess the current state of research and identify trends that may guide future investigations. Following the guidelines established by PRISMA, a total sample of 26 research papers were extracted from the electronic databases, PubMed and Scopus. These papers were categorized based on their publication dates, and research questions were formulated regarding three main topics: venom type, cancer-targeting mechanism, and cancer type. Statistical analysis of the research questions was performed using 2x2 contingency tables for a chi-square test. The results of the analysis reveal a statistically significant increase in publications focused on cell death mechanisms and breast cancer in recent years. This increase in publications reflects a growing interest in the potential for venom to induce apoptosis in cancer cells and target the unique biological properties of breast cancer. Overall, this meta-analysis offers insight into the evolving sphere of venom-based cancer research, providing a glimpse into the potential trajectory of this field.
ContributorsHolder, Marina (Author) / Amdam, Gro (Thesis director) / Mana, Miyeko (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Economics Program in CLAS (Contributor)
Created2023-12
Description
The Human Chain: Exploring Poetry and Public Service is an anthology of collected poems that present the relationship between poetry and the concept of public service. Through academic and literary exploration, the main ties between the two concepts were identified as (1) loss, (2) community, (3) advocacy, (4) appreciation and

The Human Chain: Exploring Poetry and Public Service is an anthology of collected poems that present the relationship between poetry and the concept of public service. Through academic and literary exploration, the main ties between the two concepts were identified as (1) loss, (2) community, (3) advocacy, (4) appreciation and (5) inspiration. The collection uses poetry to exemplify these thematic ties. The results of this project could be used to strengthen the relationship between the written word and organized volunteerism. There are many real-world applications of this literary exploration and is a vitally important relationship to delve into.
ContributorsMason, Hannah (Author) / O'Flaherty, Katherine (Thesis director) / Stanford, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Public Affairs (Contributor) / School of Community Resources and Development (Contributor)
Created2024-05
Description
In this paper, a novel model of Hotelling duopoly is introduced that explains horizontal product variety as the result of consumer preferences, expanding on and meshing the works of Hotelling (1929) and Neven (1985). From this model, two opposing forces from consumer preferences are found that impact the variety and

In this paper, a novel model of Hotelling duopoly is introduced that explains horizontal product variety as the result of consumer preferences, expanding on and meshing the works of Hotelling (1929) and Neven (1985). From this model, two opposing forces from consumer preferences are found that impact the variety and price decisions of firms: market share revenues and price revenues. As firms face consumers with highly linear (weak) preferences over variety, the profit incentive is to simply capture the market by offering products that appeal to the middle consumer. However, as firms face consumers with highly quadratic (strong) preferences over variety, the profit incentive is to carve out and exploit a market segment by offering a distinct variety. Thus, observed product variety between minimal and maximal differentiation is emergent from consumer preferences, as firms face a balance of price and market share incentives.
ContributorsMalaki, Adam (Author) / Leiva Bertran, Fernando (Thesis director) / Hanemann, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Economics Program in CLAS (Contributor) / School for the Future of Innovation in Society (Contributor)
Created2024-05
Description
This thesis/creative project involved writing a collection of creative nonfiction essays and building a website to reflect on my experiences traveling through Spain in the summer of 2023, for both a study abroad program and on my own. There are a total of nine essays in this current collection, along

This thesis/creative project involved writing a collection of creative nonfiction essays and building a website to reflect on my experiences traveling through Spain in the summer of 2023, for both a study abroad program and on my own. There are a total of nine essays in this current collection, along with a tenth introductory essay. They reflect the chronological order of my travels to Madrid, Sevilla, Granada, Valencia, Barcelona, and Lisbon, concluding with an essay written about my return to Phoenix, Arizona. The goal of this project was to not only personally reflect on what I learned while in these various places, but also to share these experiences with a wider audience in the digital world. I plan to continue adding essays to this website, using it as a "living document" for my future travels, and as a place for further reflection.
ContributorsCordes, Olivia (Author) / Meloy, Elizabeth (Thesis director) / O'Flaherty, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor)
Created2024-05