Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- Creators: Department of Chemistry and Biochemistry
- Creators: Martin, Thomas
Description
There are problems in the breeding practices of miniature horses. This study seeks to determine the source of these detrimental outcomes based on an evaluation of primary attributes selected for by breeders and the lack of genetic information and understanding of these attributes. In order to do this a program model was created to test the effects of selection criteria on breeder behavior and the resultant foals of these crosses. Moving forwards this program will evolve into a database of the equine genome for different horses. This will allow breeders to input their horses and do faux crosses in order to decrease the incidence of negative and detrimental outcomes.
ContributorsDavis, Marissa Lynn (Author) / Oberle, Eric (Thesis director) / Martin, Thomas (Committee member) / College of Letters and Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The 1878 Treaty of Berlin sought to address the issue of minority rights in order to stabilize the interests of the Great Powers and the international order; however, in their formulation of a treaty intended to save the imperial component of the system, the European imperial powers not only gave one of their official acknowledgments to nationalist principles, but articulated a critique of the existing notion of state protection for ethnic minorities. This tentative but landmark modification of the imperial model of legitimacy suggested Europe or the world could consist of a host of sovereign nations. In so doing, it recognized the political, and ideological changes that nationalism demanded, changes that would reshape how national groups organize politically, culturally, and militarily. The logic of nationalism demanded that new boundaries, conceived on national lines be drawn, and they were drawn, both within the Austro-Hungarian and Ottoman Empires. The Treaty of Berlin led to the formation of Greater Bulgaria and Albania, and these new nationalities formed a initial answer to the European question of minority groups. The Treaty of Berlin is useful to examine in relation to its better-known and much more radical offspring, the Treaty of Versailles. Differences in the approach of either treaty provide a study in the lasting effects of soft power to resolve international conflict. The Great Powers met in Berlin to address a developing crisis in an attempt to avoid a destabilizing regional conflict through diplomatic and legal means, whereas the Paris Peace Conference met at Versailles to develop new order across Europe in the wake of the Great War. The Treaty of Versailles, sharply chiding the Central Powers as it promulgated a victor's peace, hoped to prevent future war by placing economic burdens on Germany. While the conference at Paris acknowledged the minority position, the overwhelming legal focus went to addressing developing nations and nationalisms in a way that was consistent with the beliefs of old imperial rule. The earlier Treaty of Berlin's relative emphasis on minority questions as logically antecedent to the disposition of nationalism becomes of highest significance in retrospect. It is this focused approach to addressing developing nationalism that makes the Treaty of Berlin an important point of discussion. It provides a precedent for how questions of minority rights should be addressed, and where it falls short of an answer on how conflict might be prevented, it explores how the tensions within the international system can exacerbate one another, as they did in the breakdown of diplomacy and law that to the First World War . This thesis aims to address how the triumph of nationalism as a model of state legitimacy almost immediately gave rise to the question of legal protection of minorities. The minority question only became more urgent as nationalists developed policies that practiced first passive, and then active exclusion of minority groups. While nationalism's relation to democratic rule seemed to solve the problems of representative government, it quickly forced the question of how legitimate representation was determined. Shifting notions of political legitimacy, unworkable empires, and heightened international rivalry formed a widening spiral of crisis that eclipsed the minority question, but this thesis supports the belief that the centrifugal force of conflict came out of the avoidance of addressing minority rights completely. Attempts were made through the twentieth century to mitigate conflict between people groups, but many failed to produce fully developed solutions, while many others favored the status quo, seemingly hoping that the question would answer itself. A study of the early history of the minority rights question helps us understand the national question in the old-new light of the international order and questions of international law. Given the conflicts that have arisen out of the relations between nations and the question of minority rights, the minority question is present in much of today's thinking about human rights and the maintenance of international order. Understanding the origins of minority rights and the factors considered in the early negotiations set to address the problem helps develop a deeper understanding of the of the interactions between nations and people today.
ContributorsGobble, Tyler Scott (Author) / Oberle, Eric (Thesis director) / Martin, Thomas (Committee member) / Aviation Programs (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
It goes without saying that marriage, and the concept of two people staying together for the rest of their lives, is not easy. In today's society, divorce is something that is becoming more and more prominent among people. However, despite the divorce phenomenon there are still success stories of couples who last and manage to stick together despite the odds. It is difficult to measure the "successfulness" of any marriage due to the fact that so many different elements comprise them. However, there are endless assessments available to be used as tools for attempting measurement of success. A majority of them are related to measuring relationship quality in terms of individual satisfaction by focusing on each individual's happiness within the relationship. Obviously, every marriage is different and there are many things that can impact a couple's' likeliness to stay together such as the general circumstances surrounding their union and each partner's willingness to persevere. For instance, there are a variety of different factors that influence the overall success of marriages within and surrounding the United States Military. Such as physical proximity, frequency of communication, and a mutual desire to make the relationship work. Cultivating a relationship in which one partner is a service member and one partner is a civilian is stressful for both people involved. Specifically, the intense stress couples experience associated with deployment can often cause severe problems such as depression and anxiety that may lead to divorce or mental health problems later on down the road. Stressors specifically related to the deployment cycle can contribute to depression among both service members and their spouses. Most of these families face unique stressors through the course of military service and deployments, including frequent relocations and recon�gurations of the family system, ambiguous loss and fear for a loved one's safety, and high levels of stress and/or dysfunction among family members (Flake, Davis, Johnson, & Middleton, 2009; Huebner, Mancini, Wilcox, Grass, & Grass, 2007) Separation , unpredictable duty hours, and single parenting (parenting while the veteran is away either being deployed or on training courses) are just a few of the stressors that face partners of veterans on a regular basis (Padden, Connors & Agazio, 2011). Dr. John Gottman, the executive director of the Relationship Research Institute. has conducted extensive research regarding marital stability and divorce prediction on thousands of couples over the last forty years of his career. Using video cameras, heart monitors, and other biofeedback equipment, he and his colleagues have screened interviewed and tracked what couples experience during moments of conflict and closeness. Over the span of the last forty years, Dr. Gottman has created a theory he calls "The Four Horsemen of the Apocalypse". In the New Testament, the Four Horsemen of the Apocalypse are a metaphor marking the beginning of end times. Dr. Gottman's Four Horsemen on the other hand, are a metaphor marking the beginning of the demise of a marriage. The horsemen include criticism, contempt, defensiveness, and stonewalling. They are communication styles among couples that Dr. Gottman says can predict the end of a relationship. This notion holds true especially in the implication of military relationships. Focusing on the predictors of divorce, and inspecting the elements of these relationships in which the military is a condition of the union, discoveries can be made as to what makes these military relationships more difficult. An examination through the lens of Dr. Gottman's horsemen of the circumstances surrounding these unions in which deployment physically separates the two partners demonstrates how deployment in and of itself can cause couples to encompass each of the horsemen and eventually push them towards divorce. Throughout the course of this paper, the different elements that embody each of the four horsemen will be examined and analyzed as they pertain to the deployment process. Upon completion of the examination of these different factors, it can be suggested that deployment in its nature becomes the harbinger of the apocalypse. By encompassing all the different aspects of the first four original horsemen, and pushing military couples towards the behaviors that lead in the direction of divorce, deployment in and of itself can be thought of as predecessor, or harbinger of the apocalypse.
ContributorsSerdy, Taylor B (Author) / Martin, Thomas (Thesis director) / Mowzoon, Nura (Committee member) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Leonardo's anatomical studies of the heart demonstrate the dependency of form and function on one another and that their combined activity leads to a comprehensive understanding of the cardiovascular system. While Leonardo was able to make incredible deductions regarding the heart's anatomy and physiology through the concepts of form and function, it is evident that his preconceptions hindered him from realizing the full scope of his individual findings. In this paper, I will evaluate the perception of anatomy, the manner in which anatomical knowledge was acquired, and the resultant traditional understanding of the cardiovascular system during Leonardo's lifetime. Leonardo's drawings of the heart will then be analyzed to determine what conclusions he was able to make regarding the heart's anatomy and physiology. Finally, I will compare Leonardo's findings to the modern understanding of the cardiovascular system. Because Leonardo's anatomical studies were hidden from the world for so long, many of his conclusions regarding the heart did not come to light before other individuals had already begun to reach them on their own. Although he made incredible leaps in the understanding of the cardiovascular system, he made little contribution to modern cardiology. Now Leonardo's work can only be examined retrospectively to determine the accuracies and inaccuracies of Leonardo's conclusions in comparison to our modern understanding.
ContributorsMulligan, Kelly Suzanne (Author) / Codell, Julie (Thesis director) / Martin, Thomas (Committee member) / School of Art (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
A series of mitochondria targeting probes was synthesized for the purpose of exploring the feasibility of a mitochondria targeting fluorescent sensor. Of the probes, the probe with a two carbon spacer showed the best co-localization from staining with the established MitoTracker Red® FM, indicating a potential development of the probe into mitochondria targeting sensor. However, cytotoxicity was observed for the probe with a six carbon spacer. Three additional mitochondria targeting fluorescent probes of longer spacer groups were synthesized, but the cytotoxicity was not observed to be as high as that of the probe with a two carbon spacer. The cytotoxicity was characterized to be that of caspase dependent cell death. To screen for a possible effect on apoptosis due to the mitochondrial probe, three fluorescent fusion proteins binding the anti-apoptotic proteins were designed and expressed. Each purified fusion protein was then incubated with the cytotoxic mitochondrial probe, and the mixture was isolated by running an affinity column. The fluorescence analysis of eluted fractions showed preliminary data of possible interaction between the protein and the mitochondrial probe.
ContributorsLee, Fred (Author) / Meldrum, Deirdre R. (Thesis director) / Tian, Yanqing (Committee member) / Zhang, Liqiang (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-12
Description
An in-depth analysis of Homeview Realty and Homeview Financial was conducted. A marketing plan for both companies was prepared for this project. Homeview Realty and Homeview Financial are in the midst of dynamic industries. The landscape of doing business in the real estate and mortgage industries are constantly changing and evolving. Thus, it is vital for Homeview Realty and Homeview Financial to constantly be knowledgeable in these fields. With this dynamic aspect, the landscape for marketing has also changed; it became digital in nature. Thus, it is important to analyze Homeview Realty and Homeview Financial currently and create a live marketing plan that can be updated when needed. With a marketing plan in hand, Homeview will be able understand its business model, mission, goals, and objectives and in turn be able to create marketing campaigns compatible with the companies objectives and strategic directions.
ContributorsCrowley, Rachel Victoria (Author) / Ostrom, Lonnie (Thesis director) / Montoya, Detra (Committee member) / Mirshak, Paul (Committee member) / Barrett, The Honors College (Contributor) / Department of Marketing (Contributor) / Department of Supply Chain Management (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Finance (Contributor) / School of Accountancy (Contributor)
Created2014-05
Description
Batman is one of the most iconic characters in the history of popular culture. Ever since his creation in 1939, the character and his stories have gone through several changes. In my thesis, I explore and analyze the character within the nearly 20-year period in which he went through the most significant changes (1968-1986). Overall, these changes can be summarized as a shift from a lighthearted superhero consistently placed in campy situations to a dark and brooding vigilante who brutally dispatches his enemies. While analyzing the different versions of this character in this period of time, I reference the conclusions of two scholars: Travis Langley and Chuck Tate. Langley wrote a general psychological analysis of Batman by considering the essential characteristics of the character found in all forms of media. Tate concluded that Batman only uses hostile aggression for the sake of deriving pleasure form the pain he causes to criminals. After analyzing the comics as my primary sources, I have concluded that the general findings of Tate and Langley actually ignore the subtle details of changes in the humanity and self-awareness of the character through time. The lighthearted version of Batman in the late 60's is actually a self-obsessed narcissist, but as time passes, the darker mood of the character can be attributed to an increased acknowledgment of the destructive nature of his unique lifestyle. As the character grows more accepting of himself and his own reasons for continuing this lifestyle, his motivations become less self-centered. Overall, the central change of the character throughout time can be traced back to the status of his inner conflict between normal, human desires and the pure desire for constant vengeance.
ContributorsRivera-Passapera, Hiram Alfonso (Author) / Martin, Thomas (Thesis director) / Miller, April (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description
Repeating tiles made of DNA were used to try to form an indefinitely large structure. Both the tiles and structure were 2D. Two different patterns were tested, one corrugated and one not. Corrugation means that the tiles alternated between facing up and facing down, canceling out any curvature to the tile and creating a slightly corrugated but largely 2D pattern. Annealing methods were also experimented with. Annealing the structure in two, separate steps as opposed to one was tested. Another experiment was comparing cyclic versus linear annealing. A linear decrease in temperatures defines the linear annealing, and a cyclic method involved a linear drop to a certain temperature, followed by a slight increase in temperature and cooling back down again. This cycle is done several times before it continues linear cool down. It was seen that both corrugated and non-corrugated structures could be made. In both cases tiles that make up a larger section of the overall pattern were more successful. This is especially important for the non-corrugated pattern. Linear and 2step annealing methods seem to yield the best results.
ContributorsHunt, Ashley Elizabeth (Author) / Yan, Liu (Thesis director) / Yan, Hao (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2015-05
Description
Lung cancer is the leading cause of cancer-related deaths in the US. Low-dose computed tomography (LDCT) scans are speculated to reduce lung cancer mortality. However LDCT scans impose multiple risks including false-negative results, false- positive results, overdiagnosis, and cancer due to repeated exposure to radiation. Immunosignaturing is a new method proposed to screen and detect lung cancer, eliminating the risks associated with LDCT scans. Known and blinded primary blood sera from participants with lung cancer and no cancer were run on peptide microarrays and analyzed. Immunosignatures for each known sample collectively indicated 120 peptides unique to lung cancer and non-cancer participants. These 120 peptides were used to determine the status of the blinded samples. Verification of the results from Vanderbilt is pending.
ContributorsNguyen, Geneva Trieu (Author) / Woodbury, Neal (Thesis director) / Zhao, Zhan-Gong (Committee member) / Stafford, Phillip (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Psychology (Contributor)
Created2015-05
Description
The purpose of this project was to identify proteins associated with the migration and invasion of non-transformed MCF10A mammary epithelial cells with ectopically expressed missense mutations in p53. Because of the prevalence of TP53 missense mutations in basal-like and triple-negative breast cancer tumors, understanding the effect of TP53 mutations on the phenotypic expression of human mammary epithelial cells may offer new therapeutic targets for those currently lacking in treatment options. As such, MCF10A mammary epithelial cells ectopically overexpressing structural mutations (G245S, H179R, R175H, Y163C, Y220C, and Y234C) and DNA-binding mutations (R248Q, R248W, R273C, and R273H) in the DNA-binding domain were selected for use in this project. Overexpression of p53 in the mutant cell lines was confirmed by western blot and q-PCR analysis targeting the V5 epitope tag present in the pLenti4 vector used to transduce TP53 into the mutant cell lines. Characterization of the invasion and migration phenotypes resulting from the overexpression of p53 in the mutant cell lines was achieved using transwell invasion and migration assays with Boyden chambers. Statistical analysis showed that three cell lines—DNA-contact mutants R248W and R273C and structural mutant Y220C—were consistently more migratory and invasive and demonstrated a relationship between the migration and invasion properties of the mutant cell lines. Two families of proteins were then explored: those involved in the Epithelial-Mesenchymal Transition (EMT) and matrix metalloproteinases (MMPs). Results of q-PCR and immunofluorescence analysis of epithelial marker E-cadherin and mesenchymal proteins Slug and Vimentin did not show a clear relationship between mRNA and protein expression levels with the migration and invasiveness phenotypes observed in the transwell studies. Results of western blotting, q-PCR, and zymography of MMP-2 and MMP-9 also did not show any consistent results indicating a definite relationship between MMPs and the overall invasiveness of the cells. Finally, two drugs were tested as possible treatments inhibiting invasiveness: ebselen and SBI-183. These drugs were tested on only the most invasive of the MCF10A p53 mutant cell lines (R248W, R273C, and Y220C). Results of invasion assay following 30 μM treatment with ebselen and SBI-183 showed that ebselen does not inhibit invasiveness; SBI-183, however, did inhibit invasiveness in all three cell lines tested. As such, SBI-183 will be an important compound to study in the future as a treatment that could potentially serve to benefit triple-negative or basal-like breast cancer patients who currently lack therapeutic treatment options.
ContributorsZhang, Kathie Q (Author) / LaBaer, Joshua (Thesis director) / Anderson, Karen (Committee member) / Gonzalez, Laura (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2015-05