Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- Creators: School of Life Sciences
- Creators: Arizona State University. College of Nursing & Healthcare Innovation
- Creators: Loebenberg, Abby
The goal of the updated eight session SSLN program is to decrease BMI, increase nutritional knowledge, and improve attitude and behavior towards nutrition and physical activity in Hispanic school-aged children. After meeting with Esperança to identify which elements of the curriculum needed modification, an extensive literature review was conducted to identify new and relevant research appropriate to the modifications. Integrating child development theories, social behavior theory, and results from earlier successful obesity intervention programs, curriculum sessions will be condensed and modified using a community base participatory research approach. Once edits to the curriculum are completed and approved, Esperança will implement the newly modified curriculum, and evaluate the success of the curriculum changes.
The final project is composed of a condensed, theory-based, culturally responsive, and developmentally age appropriate eight session curricula that will educate Hispanic school-aged children on nutrition and physical activity.
To determine if the disruption of the MMR pathway results in the reduced conservation of methylated adenines as well as an increased tolerance for mutations that result in the loss or gain of new GATC sites, we surveyed individual clones isolated from experimentally evolving wild-type and MMR-deficient (mutL- ;conferring an 150x increase in mutation rate) populations of E. coli with whole-genome sequencing. Initial analysis revealed a lack of mutations affecting methylation sites (GATC tetranucleotides) in wild-type clones. However, the inherent low mutation rates conferred by the wild-type background render this result inconclusive, due to a lack of statistical power, and reveal a need for a more direct measure of changes in methylation status. Thus as a first step to comparative methylomics, we benchmarked four different methylation-calling pipelines on three biological replicates of the wildtype progenitor strain for our evolved populations.
While it is understood that these methylated sites play a role in the MMR pathway, it is not fully understood the full extent of their effect on the genome. Thus the goal of this thesis was to better understand the forces which maintain the genome, specifically concerning m6A within the GATC motif.