Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- Creators: W. P. Carey School of Business
Description
This study focused on the connection between the EnvZ/OmpR two-component regulatory system and the iron homeostasis system in Escherichia coli, specifically how a mutant form of EnvZ11/OmpR is able to reduce the expression of fepA::lacZ, a reporter gene fusion in E. coli. FepA is one of several outer membrane siderophore receptors that allow extracellular siderophores bound to iron to enter the cells to power various biological processes. Previous studies have shown that in E. coli cells that expressed a mutant allele of envZ, called envZ11, which led to altered expression of various iron genes including down regulation of fepA::lacZ. The wild type EnvZ/OmpR system is not considered to regulate iron genes, but because these envz11 strains had downregulated fepA::lacZ, this study was undertaken to understand the connection and mechanisms of this downregulation. A large number of Lac+ revertants were obtained from the B32-2483 strain (envz11 and fepA::lacZ) and 7 Lac+ revertants that had reversion mutations not directly correcting the envZ11 allele were further characterized. With P1 phage transduction genetic mapping that involved moving a kanamycin resistance marker linked to fepA::lacZ, two Lac+ revertants were found to have their reversion mutations in the fepA promoter region, while the other five revertants had their mutations mapping outside the fepA region. These two revertants underwent DNA sequencing and found to carry two different single base pair mutations in two different locations of the fepA promoter region. Each one is in the Fur repressor binding region, but one also may have affected the Shine-Dalgarno region involved in translation initiation. All 7 reveratants underwent beta-galactosidase assays to measure fepA::lacZ expression. The two revertants that had mutations in the fepA promoter region had significantly increased fepA activity, with the revertant with the Shine-Dalgarno mutation having the most elevated fepA expression. The other 5 revertants that did not map in the fepA region had fepA expression elevated to the same level as that found in the wild type EnvZ/OmpR background. The data suggest that the negative effect of envZ11 can be overcome by multiple mechanisms, including directly correcting the envZ11 allele or changing the fepA promoter region.
ContributorsKalinkin, Victor Arkady (Co-author) / Misra, Rajeev (Co-author, Thesis director) / Mason, Hugh (Committee member) / Foy, Joseph (Committee member) / Biomedical Informatics Program (Contributor) / School of Life Sciences (Contributor) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
DescriptionThe project consisted on creating a model for a venture capital firm to use that would help in screening through investment opportunities.
ContributorsRojo, Grecia (Co-author) / Cullen, Justin (Co-author) / Gandhi, Prayas (Co-author) / Brooks, Daniel (Thesis director) / Foy, Joseph (Committee member) / O'Brien, Jennifer (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / W. P. Carey School of Business (Contributor)
Created2013-05
Description
This is a book proposal for a Study Abroad Survival Guide entitled "A Guide to Conquering Study Abroad: My Experience in Western Europe." It includes both a proposal and manuscript. The proposal is directed at Avalon Travel, a large publisher. The manuscript follows the book proposal and would also be sent to the publisher. My book highlights key things that students must know about going abroad before they go, while they are there, and when they get back. This information will be presented in a hard copy and an eBook. This book's purpose is to encourage students to study abroad and help prepare them for the adventures ahead. While studying abroad in Rome for a semester, I realized I wanted to help persuade students that studying abroad is an unbelievable opportunity, and wanted to help answer their questions that arise before and along the way. Distribution for this book will begin locally at Arizona State University before moving to other college campuses. The marketing focus will be on other Pac-12 Universities. Scouring the internet and library databases reveals no book that fills this niche of advising college students thinking about, or already studying abroad. Part of the reason I am the best person to write a study abroad survival guide is because I went abroad and had a very successful trip.
ContributorsPfeiffer, Ryan Edward (Author) / deLusé, Stephanie (Thesis director) / Foy, Joseph (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / Department of Marketing (Contributor) / Department of Finance (Contributor)
Created2014-05
Description
This project was designed to capture family stories. Three generations of family members were interviewed on the topics of work and family, using oral history methods. The following trends in thinking were identified after analysis of the interview transcripts: education, work ethic, attachment to place, importance of mothers, and divorce. These trends were then further analyzed to see how they affect the family members across the three generations. Additionally, connections were drawn to significant factors in United States and Arizona history to help explain why things are the way they are in the family.
ContributorsMoran, Madeline Nicole (Author) / Popova, Laura (Thesis director) / Foy, Joseph (Committee member) / W. P. Carey School of Business (Contributor) / School of Accountancy (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05