Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 10 of 85
Description
Fluoroquinolone antibiotics have been known to cause severe, multisystem adverse side effects, termed fluoroquinolone toxicity (FQT). This toxicity syndrome can present with adverse effects that vary from individual to individual, including effects on the musculoskeletal and nervous systems, among others. The mechanism behind FQT in mammals is not known, although various possibilities have been investigated. Among the hypothesized FQT mechanisms, those that could potentially explain multisystem toxicity include off-target mammalian topoisomerase interactions, increased production of reactive oxygen species, oxidative stress, and oxidative damage, as well as metal chelating properties of FQs. This review presents relevant information on fluoroquinolone antibiotics and FQT and explores the mechanisms that have been proposed. A fluoroquinolone-induced increase in reactive oxygen species and subsequent oxidative stress and damage presents the strongest evidence to explain this multisystem toxicity syndrome. Understanding the mechanism of FQT in mammals is important to aid in the prevention and treatment of this condition.
ContributorsHall, Brooke Ashlyn (Author) / Redding, Kevin (Thesis director) / Wideman, Jeremy (Committee member) / Borges, Chad (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
The issue of adolescent dating violence is a relatively new field of research, but several studies have shown that adolescent dating violence is distinct from adult domestic violence and has its own implications and patterns. Many studies have shown that both males and females appear to be the victims and perpetrators of dating violence, and often times in abusive dating relationships, the perpetration is mutual. Involvement with adolescent dating violence has serious physical and psychological health consequences, and in order to combat this social phenomenon, effective prevention programs are needed. The present study discusses key characteristics of school-based prevention programs that have been shown to be effective, as well as looks specifically at one such prevention program called BLOOM for Healthy Relationships™. The researcher in this study originally set out to conduct a program evaluation of BLOOM, but encountered several obstacles with the approval process that prevented the evaluation from being completed in the available time frame. This report is now framed as a case study that will discuss the necessary resources for preparing to conduct a program evaluation, describe the obstacles encountered in the approval process and make suggestions for future strategies to complete program evaluations of BLOOM.
ContributorsKellums, Megan Marie (Author) / Updegraff, Kimberly (Thesis director) / Dumka, Larry (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Psychology (Contributor)
Created2014-05
Description
Bacteria play a vital role in the world ecosystem, more importantly human health and disease. The capability to differentiate and identify these microorganisms serves as an important research objective. In past years, separations-based approaches have served as a way to observe and identify bacteria based on their characteristics. Gradient insulator dielectrophoresis (g-iDEP) provides benefits in identifying serotypes of a single species with precise separation. Separation of Staphylococcus epidermidis in a single g-iDEP microchannel is conducted exploiting their electrophoretic and electrokinetic properties. The cells were captured and concentrated at gates with interacting forces within the microchannel to clearly distinguish between the two strains. These results provide support for g-iDEP serving as a separating method and, furthermore, future clinical applications.
ContributorsDavis, Paige Elizabeth (Author) / Hayes, Mark (Thesis director) / Borges, Chad (Committee member) / Jones, Paul (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor)
Created2015-05
Description
The Paradise Valley Family Resource Center (PVFRC) is a not for profit, community based organization funded by First Things First and a part of the Paradise Valley Unified School District (PVUSD) in Phoenix, Arizona. The mission of this organization is to connect and strengthen families with children from birth to five years old in the Phoenix valley. The PVFRC longed to be more cognizant of what the needs of the community they serve are, and how they, as an organization, can administer programs of value to the community. Hence, the PVFRC entered a partnership with the Community Action Research Experiences (CARE) program at Arizona State University to develop a research proposal to improve their effectiveness and efficiency at achieving their mission. The purpose of this research project was to identify and evaluate the needs of the families with children ages birth to five within the community, to improve upon existing programs and services or to implement new programs, and to discover more effective modes of awareness and advertisement to the community about the programs and services the PVFRC provides. The main research questions of the experiment included asking participants about what programs and services they need, wish, or want to exist at the PVFRC, what barriers or gaps they see or experience regarding attending the PVFRC, how did participants learn about the PVFRC, and what are the best ways to contact families in their community. The methods of the research included conducting focus group interviews with families who utilize the programs and services at the PVFRC and with early childhood professionals in the Paradise Valley Unified School District (PVUSD), which included social workers and preschool teachers. A total of 25 participants were interviewed (10 families, 6 social workers, and 9 preschool teachers) and responses from the interviews were coded by the researcher. The results of the research was that the PVFRC is meeting many needs and current families are satisfied, participants desire some changes to current programs and services, and the best modes of advertisement and awareness were "word of mouth" and the internet. It was recommended that in order to better achieve their mission, it is advised that the PVFRC make appropriate changes to programs and services as suggested by the participants, connect with mom's or parents groups in the community, collaborate with preschool teachers on the front line, and increase their online presence through the use of social media and their website.
ContributorsHoran, Mary Jensen (Author) / Foster, Stacie (Thesis director) / Brougham, Jennifer (Committee member) / Dumka, Larry (Committee member) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / School of Molecular Sciences (Contributor) / School for the Science of Health Care Delivery (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The Community Action Research Experiences (CARE) program collaborated with Singleton Moms, a local non-profit organization that provides financial, psychological, and social support services to single parents with cancer. The purpose of this action research project was to assess the volunteer program at Singleton Moms. Both past and present Singleton Moms' volunteers (N = 123; 87.0% female) completed an online survey assessing their motivation for volunteering and their satisfaction with the organization. A mixed ANOVA was conducted to identify the most important motivation and satisfaction domains and to see if the findings depended on whether the volunteers were current or past volunteers. For the motivation assessment, results indicated that the volunteers rate the cancer specific and moral/human kindness domains as the strongest reasons for motivating them to volunteer at Singleton Moms. In addition, results revealed that the social connection motivation domain was the only domain with differences between the ratings of the past and present volunteers. For the satisfaction assessment, results indicated that the volunteers rate the organizational climate domain as the most fulfilled area of satisfaction within the Singleton Moms' volunteer program. It was also revealed that there were no significant differences between the ratings of the past and present volunteers among all satisfaction domains. Both the quantitative and qualitative findings suggest that Singleton Moms' implications for action may include: 1) a volunteer database audit, 2) streamlining communications, 3) variability in volunteer times, and 4) bolstering volunteer motivation. Implementing some of these actions may help Singleton Moms increase volunteer motivation and satisfaction and thus create a more effective volunteer program. Ultimately, this may encourage volunteers to continue their services at Singleton Moms and thus help Singleton Moms expand their support programs and assist additional families.
ContributorsDubois, Courtney Michelle (Author) / Miller, Cindy (Thesis director) / Dumka, Larry (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor)
Created2016-05
Description
Background: High risk types of human papillomavirus (HPV) are known to cause cancer, including cervical (99%) and oropharyngeal cancer (70%). HPV type 16 is the most common subtype. Three antigens that are critical for integration or tumor progression are E2, E6 and E7. In this study, we developed a systematic approach to identify naturally-processed HPV16-derived HLA class I epitopes for immunotherapy development. Methods: K562 cells, which lack HLA expression, were transduced with each HPV16 antigen using lentivirus and supertransfected with HLA-A2 by nucleofection. Stable cell lines expressing each antigen were selected for and maintained throughout the investigation. In order to establish a Gateway-compatible vector for robust transient gene expression, a Gateway recombination expression cloning cassette was inserted into the commercial Lonza pMAX GFP backbone, which has been experimentally shown to display high transfection expression efficiency. GFP was cloned into the vector and plain K562 cells were transfected with the plasmid by nucleofection. Results: Expression of K562-A2 was tested at various time points by flow cytometry and A2 expression was confirmed. Protein expression was shown for the transduced K562 E7 by Western blot analysis. High transfection efficiency of the pMAX_GFP_Dest vector (up to 97% GFP+ cells) was obtained 48 hours post transfection, comparable to the commercial GFP-plasmid. Conclusion: We have established a rapid system for target viral antigen co-expression with single HLA molecules for analysis of antigen presentation. Using HPV as a model system, our goal is to identify specific antigenic peptide sequences to develop immunotherapeutic treatments for HPV-associated cancers.
ContributorsVarda, Bianca Marie (Author) / Anderson, Karen (Thesis director) / Borges, Chad (Committee member) / Krishna, Sri (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The purpose of this study, conducted via the Community Action Research Experiences (CARE) Program in association with Arizona State University's T. Denny Sanford School of Social and Family Dynamics, was to expand the influence of Open Table, a faith-based, non-profit organization dedicated to equipping the impoverished with the necessary tools to restore them back to self-sufficiency through the power of relationship. The study sought to aid the organization's expansion through an analysis of the decision-making process leaders from faith congregations undergo to establish or continue partnerships with Open Table. A series of interviews were conducted with leaders from congregations currently partnered with Open Table to determine the nature of the decision-making process for adopting Open Table into their congregations, the expectations of the Open Table model for reaching the impoverished, and to what degree those expectations were met. Nine interviews were conducted from which the following results were derived. The key results revealed that congregation leaders other than the lead pastor often conducted the majority of the decision-making in regard to adopting and implementing Open Table within the various congregations. The decision to adopt Open Table often was based on whether or not any particular congregation's mission and values aligned with that of the organizations. Some expectations leaders had of Open Table were for their congregation members to receive a richer education of poverty and to help an individual exit poverty. For the most part, the results revealed that these expectations were frequently met.
ContributorsHoover, Nicole Rene (Author) / Ostrom, Amy (Thesis director) / Dumka, Larry (Committee member) / Barrett, The Honors College (Contributor) / School of Letters and Sciences (Contributor) / Department of English (Contributor)
Created2014-05
Description
There is a serious need for early childhood intervention practices for children who are living at or below the poverty line. Since 1965 Head Start has provided a federally funded, free preschool program for children in this population. The City of Phoenix Head Start program consists of nine delegate agencies, seven of which reside in school districts. These agencies are currently not conducting local longitudinal evaluations of their preschool graduates. The purpose of this study was to recommend initial steps the City of Phoenix grantee and the delegate agencies can take to begin a longitudinal evaluation process of their Head Start programs. Seven City of Phoenix Head Start agency directors were interviewed. These interviews provided information about the attitudes of the directors when considering longitudinal evaluations and how Head Start already evaluates their programs through internal assessments. The researcher also took notes on the Third Grade Follow-Up to the Head Start Executive Summary in order to make recommendations to the City of Phoenix Head Start programs about the best practices for longitudinal student evaluations.
ContributorsArmfield, Jessica Ann (Author) / Duggan, Mary Anne (Thesis director) / Dumka, Larry (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / School of International Letters and Cultures (Contributor)
Created2014-05
Description
Community gardens are used worldwide to promote sustainable, urban living. They can be used to improve the physical, mental, emotional, and social health of the gardeners and volunteers who utilize their grounds. The gardens may also have a positive impact on the local environment and wider community. This study examines a community garden seeking to expand its involvement in the local neighborhood and searching for ways to include local residents in garden related activities. To this end, the garden was waiting for approval on their non-profit, 501(c)3 status, and was seeking additional data on local residents and perceptions of the garden's activities. This thesis first reviews the literature on the benefits community gardens provide for the individuals living in their communities and their impact on urban development. The thesis then turns to an analysis of one garden, Mesa Urban Garden, rooted in the Downtown District of Mesa, Arizona, and how they are impacting their neighborhood and how garden organizers can respond in new and creative ways to local residents.
ContributorsBooher, Samantha Rose (Author) / Glick, Jennifer (Thesis director) / Dumka, Larry (Committee member) / Barrett, The Honors College (Contributor) / Hugh Downs School of Human Communication (Contributor) / School of Sustainability (Contributor)
Created2014-05
Description
Community gardens are used worldwide to promote sustainable, urban living. They can be used to improve the physical, mental, emotional, and social health of the gardeners and volunteers who utilize their grounds. The gardens may also have a positive impact on the local environment and wider community. This study examines a community garden seeking to expand its involvement in the local neighborhood and searching for ways to include local residents in garden related activities. To this end, the garden was waiting for approval on their non-profit, 501(c)3 status, and was seeking additional data on local residents and perceptions of the garden's activities. This thesis first reviews the literature on the benefits community gardens provide for the individuals living in their communities and their impact on urban development. The thesis then turns to an analysis of one garden, Mesa Urban Garden, rooted in the Downtown District of Mesa, Arizona, and how they are impacting their neighborhood and how garden organizers can respond in new and creative ways to local residents.
ContributorsBooher, Samantha Rose (Author) / Glick, Jennifer (Thesis director) / Dumka, Larry (Committee member) / Barrett, The Honors College (Contributor) / Hugh Downs School of Human Communication (Contributor) / School of Sustainability (Contributor)
Created2014-05