Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 10 of 35
Description
Breast cancer is the leading cause of cancer-related deaths of women in the united states. Traditionally, Breast cancer is predominantly treated by a combination of surgery, chemotherapy, and radiation therapy. However, due to the significant negative side effects associated with these traditional treatments, there has been substantial efforts to develop alternative therapies to treat cancer. One such alternative therapy is a peptide-based therapeutic cancer vaccine. Therapeutic cancer vaccines enhance an individual's immune response to a specific tumor. They are capable of doing this through artificial activation of tumor specific CTLs (Cytotoxic T Lymphocytes). However, in order to artificially activate tumor specific CTLs, a patient must be treated with immunogenic epitopes derived from their specific cancer type. We have identified that the tumor associated antigen, TPD52, is an ideal target for a therapeutic cancer vaccine. This designation was due to the overexpression of TPD52 in a variety of different cancer types. In order to start the development of a therapeutic cancer vaccine for TPD52-related cancers, we have devised a two-step strategy. First, we plan to create a list of potential TPD52 epitopes by using epitope binding and processing prediction tools. Second, we plan to attempt to experimentally identify MHC class I TPD52 epitopes in vitro. We identified 942 potential 9 and 10 amino acid epitopes for the HLAs A1, A2, A3, A11, A24, B07, B27, B35, B44. These epitopes were predicted by using a combination of 3 binding prediction tools and 2 processing prediction tools. From these 942 potential epitopes, we selected the top 50 epitopes ranked by a combination of binding and processing scores. Due to the promiscuity of some predicted epitopes for multiple HLAs, we ordered 38 synthetic epitopes from the list of the top 50 epitope. We also performed a frequency analysis of the TPD52 protein sequence and identified 3 high volume regions of high epitope production. After the epitope predictions were completed, we proceeded to attempt to experimentally detected presented TPD52 epitopes. First, we successful transduced parental K562 cells with TPD52. After transduction, we started the optimization process for the immunoprecipitation protocol. The optimization of the immunoprecipitation protocol proved to be more difficult than originally believed and was the main reason that we were unable to progress past the transduction of the parental cells. However, we believe that we have identified the issues and will be able to complete the experiment in the coming months.
ContributorsWilson, Eric Andrew (Author) / Anderson, Karen (Thesis director) / Borges, Chad (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Brown adipose tissue (BAT) is thought to be important in combating obesity as it can expend energy in the form of heat, e.g. thermogenesis. The goal of this study was to study the effect of injected norepinephrine (NE) on the activation of BAT in rats that were fed a high fat diet (HFD). A dose of 0.25 mg/kg NE was used to elicit a temperature response that was measured using transponders inserted subcutaneously over the BAT and lower back and intraperitoneally to measure the core temperature. The results found that the thermic effect of the BAT increased after the transition from low fat diet to a high fat diet (LFD) yet, after prolonged exposure to the HFD, the effects resembled levels found with the LFD. This suggests that while a HFD may stimulate the effect of BAT, long term exposure may have adverse effects on BAT activity. This may be due to internal factors that will need to be examined further.
ContributorsSion, Paul William (Author) / Herman, Richard (Thesis director) / Borges, Chad (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Aberrant glycosylation has been shown to be linked to specific cancers, and using this idea, it was proposed that the levels of glycans in the blood could predict stage I adenocarcinoma. To track this glycosylation, glycan were broken down into glycan nodes via methylation analysis. This analysis utilized information from N-, O-, and lipid linked glycans detected from gas chromatography-mass spectrometry. The resulting glycan node-ratios represent the initial quantitative data that were used in this experiment.
For this experiment, two Sets of 50 µl blood plasma samples were provided by NYU Medical School. These samples were then analyzed by Dr. Borges’s lab so that they contained normalized biomarker levels from patients with stage 1 adenocarcinoma and control patients with matched age, smoking status, and gender were examined. An ROC curve was constructed under individual and paired conditions and AUC calculated in Wolfram Mathematica 10.2. Methods such as increasing size of training set, using hard vs. soft margins, and processing biomarkers together and individually were used in order to increase the AUC. Using a soft margin for this particular data set was proved to be most useful compared to the initial set hard margin, raising the AUC from 0.6013 to 0.6585. In regards to which biomarkers yielded the better value, 6-Glc/6-Man and 3,6-Gal glycan node ratios had the best with 0.7687 AUC and a sensitivity of .7684 and specificity of .6051. While this is not enough accuracy to become a primary diagnostic tool for diagnosing stage I adenocarcinoma, the methods examined in the paper should be evaluated further. . By comparison, the current clinical standard blood test for prostate cancer that has an AUC of only 0.67.
For this experiment, two Sets of 50 µl blood plasma samples were provided by NYU Medical School. These samples were then analyzed by Dr. Borges’s lab so that they contained normalized biomarker levels from patients with stage 1 adenocarcinoma and control patients with matched age, smoking status, and gender were examined. An ROC curve was constructed under individual and paired conditions and AUC calculated in Wolfram Mathematica 10.2. Methods such as increasing size of training set, using hard vs. soft margins, and processing biomarkers together and individually were used in order to increase the AUC. Using a soft margin for this particular data set was proved to be most useful compared to the initial set hard margin, raising the AUC from 0.6013 to 0.6585. In regards to which biomarkers yielded the better value, 6-Glc/6-Man and 3,6-Gal glycan node ratios had the best with 0.7687 AUC and a sensitivity of .7684 and specificity of .6051. While this is not enough accuracy to become a primary diagnostic tool for diagnosing stage I adenocarcinoma, the methods examined in the paper should be evaluated further. . By comparison, the current clinical standard blood test for prostate cancer that has an AUC of only 0.67.
ContributorsDe Jesus, Celine Spicer (Author) / Taylor, Thomas (Thesis director) / Borges, Chad (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Usually a medical website has a description, or overview, of the condition. Then there are different sections informing the viewer about the signs and symptoms, diagnosis, and treatment options. There are some resource links for families to explore, but there it provides more information rather than narration. What is lacking is a patient account or perspective on the given topic. This project suggests an added resource for parents and patients with its storytelling element that is irreplaceable. An example is also available using my own story growing up with hemifacial microsomia.
ContributorsCanales, Alicia Marie (Author) / Dixon, Kathleen (Thesis director) / Dodge, Nancie (Committee member) / Barrett, The Honors College (Contributor) / Department of Marketing (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor)
Created2014-12
Description
Late life domestic violence is essentially synonymous with domestic violence except that it specifically refers to older adults. Although there are many similarities between younger victims and older victims, there are also distinct differences. Older victims have unique risk factors and barriers, including generational factors that stem from socialization. Unfortunately, society lacks awareness of late life domestic violence. This is reflected in current state statutes as well as the limited services provided to victims of domestic violence. For example, there are currently elder abuse or dependent abuse adult statutes in every state, yet there is no statute that specifically addresses late life domestic violence. When it comes to services, many programs are geared toward younger victims and staff is typically not trained to work with older victims, so older victims often do not get the resources they need. Yet about 1 in 10 women over the age of 50 experience abuse by an intimate partner. This is a prevalent issue needing more attention. To bring awareness and educate people on this topic, a user friendly website was created that will provide information on late life domestic violence, resources for victims, and ways to share the information with others. The website provides information that will educate people on this issue, and also promotes advocacy for older victims.
ContributorsGarcia, Brittany Nicole (Author) / Bonifas, Robin (Thesis director) / Dodge, Nancie (Committee member) / Barrett, The Honors College (Contributor) / School of Social Work (Contributor)
Created2015-05
Description
PHXmuraltour is an app for iPhone and Android that guides users through the plethora of mural art in downtown Phoenix. It can be found and downloaded from iTunes and the Android app store. Before the artists began drawing people downtown for events like First Fridays and ArtDetour during the 1980s, Phoenix was notorious for having a deserted city core. The art community brought life, color and vibrancy to the downtown landscape. The website giving more information about the project can be found at http://kristenhwang.com/PHX-mural-tour.html. This project aims to widen the reach of the mural art in downtown Phoenix. Public art has the unique ability to foster a conversation between people who may not think of themselves as art connoisseurs, but like all kinds of art the message can sometimes be mysterious to passersby. Many of the murals downtown portray Hispanic or Native American themes, make political statements, document historic events and people, or serve as visual spice. They are emblems of the values the downtown community identifies with--values like creativity, enterprise, civic responsibility and diversity. This project hopes to make these messages more prominent to people in downtown Phoenix. It is important for the students, workers, shop owners and residents downtown to have the opportunity to learn more about the mural art because the art community surrounding Roosevelt Row played an integral role in shaping the culture and texture of their daily lives.
ContributorsHwang, Kristen Lee Anne (Author) / Thornton, Leslie (Thesis director) / Dodge, Nancie (Committee member) / Barrett, The Honors College (Contributor) / School of Earth and Space Exploration (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor)
Created2014-12
Description
For my thesis project, I created a website, titled Noise + Heat, to serve as a guide to local music in the Phoenix area. The idea is that someone who is unfamiliar with Phoenix music can visit my site and easily be able to find the latest news, new music releases, live music venues, and be able to familiarize themselves with local artists. I designed and built the site in Adobe Edge Animate, and created all content. The website can be found at this link: www.noiseplusheat.com
ContributorsDinell, Sarah Constance (Author) / Jacoby, Jim (Thesis director) / Dodge, Nancie (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor)
Created2014-12
Description
In the 1950s-60s, the United States performed nuclear testing 60 miles north of Las Vegas. The prevailing winds carried radiation from those tests across the United States. It didn't take long for groups of people to begin developing cancer, possibly as a side effect of the testing. In 1990, Congress established a program to compensate downwind victims of the test site. But one portion of one county in Arizona was never compensated, despite the impact cancer had in the area. This documentary is their story. (Documentary and website accessible at downwinddocumentary.com)
ContributorsBoehm, Jessica Ann (Author) / Elliott, Steve (Thesis director) / Dodge, Nancie (Committee member) / Snyder, Brian (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / School of Politics and Global Studies (Contributor)
Created2014-05
Description
The purpose of this creative project is to make an E-Book that promotes time management for college students in a way that interests them. The author of this recognizes that there are many distractions to keep college students from sitting down and reading a textbook; that is why an E-Book featuring videos and interactive videos was chosen. The research questions presented below began my research and understanding of the topic. These questions are as follows: 1. What is a way to promote time management for college students? a) What are some mediums that will appeal to young people who want to do more than just read a book. 2. When figuring out how to manage their time, what are the areas of life students consider to be most important? 3. What perspectives to various facets of the world like, business, academia and the foreign community think about time management? 4. What perspective to millennials have on time management? By answering these questions above, the author hopes to understand what is good time management, and how to explore it in a way that will interest young people. The author is doing so by creating a series of narrative videos that he himself acted in portraying a fictitious student both engaging in and not practicing good time management techniques. The created nine videos, with three dedicated to a section each. The three sections were what students do wrong, how they can improve and how they can maintain their success. Within each section were three sub- sections that students must use time management skills for: mental techniques, physical well-being, and juggling work and personal commitments. See the attached documents (Appendix A) for a full collection of the scripts that were created for these videos. The author also created quizzes through the website Bookry, allowing him to make review questions for those reading the book. The quizzes were then made into widgets and inserted into the book. Each quiz was about 5 questions each and was at the end of each of the sub-sections, meaning there were 45 questions total. See the attached documents (Appendix B) for screenshots of each quiz question and the correct answer.
ContributorsCzajka, Jagger James (Author) / Silcock, Bill (Thesis director) / Rodriguez, Rick (Committee member) / Dodge, Nancie (Committee member) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
DescriptionThe city of Siena is picturesque as an almost perfectly preserved medieval fortress in the heart of Tuscany. But the true beauty stems from its unique, family-oriented culture.
ContributorsPrice, Tea Francesca (Author) / Silcock, Bill (Thesis director) / Dell'Anna, Antonella (Committee member) / Dodge, Nancie (Committee member) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05