Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Filtering by
- All Subjects: cerebellum
- Creators: Doane, Leah
Social isolation in early childhood can have life-long effects on social behaviors and development. Cerebellar crus I has additionally been linked to social behaviors through forebrain pathways. In this study, we hypothesized that social isolation of mice from postnatal day 21 (P21) until p35 would result in impaired social behaviors. Additionally, we hypothesized that gq DREADD injections into crus I, to increase levels of cerebellar stimulation, at the start of the isolation period would counteract the effects of isolation, leading to mice who displayed normal social behaviors. Social behavior at P35 was tested using the 3-Chamber Task, a well-established model, and SLEAP deep-learning software was used to obtain quantifiable data. We found no difference in social behaviors between socially raised and isolated mice. However, gq DREADD mice displayed greater levels of social interaction and exploration than either socially raised mice or isolated mice. This research carries implications for possible therapeutic interventions for groups prone to social isolation, such as those with developmental disabilities, minority groups, the elderly, and prison populations.