Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- Creators: College of Health Solutions
Description
Autism Spectrum Disorder (ASD) is an intricate neurodevelopmental disorder characterized by impaired social functioning and communication, repetitive behavioral patterns, and specialized interests (Olesova et al., 2020; Osredkar et al., 2023). Despite the efforts of modern science, the biological origin of ASD is unknown, and no known biomarker for ASD currently exists (Olesova et al., 2020; Osredkar et al., 2023). Indoxyl sulfate has been identified as a toxin associated with ASD and its related symptomology in addition to a number of other conditions, including chronic kidney disease, acute kidney injury, heart failure, Parkinson’s disease, and various mood disorders (Cao et al., 2015; Cassani et al., 2015; Karbowska et al., 2020; Zhao et al., 2013). This article will review what is currently known about indoxyl sulfate in relation to ASD and its comorbidities in an attempt to determine the validity of indoxyl sulfate as a potential biomarker for ASD. Articles for the purposes of this review were collected via Google Scholar, PubMed, and the ASU Library using key words such as “indoxyl sulfate,” “Autism,” and “indican,” and chosen based on relevancy. Through this review, indoxyl sulfate was identified as a potential physiological biomarker for a subset of ASD, with additional research required to verify the findings presented. The identification of a biomarker for ASD could change the current methods of testing for ASD, greatly improving our understanding and treatment of the disorder.
ContributorsHill, Zoë (Author) / Adams, James (Thesis director) / Flynn, Christina (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor) / Edson College of Nursing and Health Innovation (Contributor)
Created2024-05
Description
Internal and external emotion recognition is universal knowledge individuals begin to understand in early childhood. Children diagnosed with Autism Spectrum Disorder (ASD) have physiological impairments that affect their social functioning, behavior, and emotion regulation. They often have difficulty revealing true emotions as opposed to mimicked emotions, which can make social connections challenging. In this pilot study, children with high-functioning and low-functioning ASD were observed in their therapy clinic, KidzSPOT Therapy, while watching a four-minute Pixar™ video as pre and post measures. The children were their own control from pre to post-evaluation. The animated characters and situations shown in the Pixar™ videos throughout the study exhibited two specific emotions: happy and sad. For six-weeks at home, children and their caregivers were asked to watch two, four-minute PixarTM videos a week on non-consecutive days and were recorded with cellular devices. Noldus FaceReader™ was used to analyze and determine increased emotional arousal of the children from recordings sent by their caregivers as they watched the videos at home. The Circumplex Model of Affect from the Noldus FaceReader™ analysis exposed the children’s active and inactive responses. The children sought support from their caregivers and therapists as a form of validation and situational understanding. The data did not display evidence of significant correlation between variables and emotional change over the course of the study. There were many limitations to this pilot study resulting in inadequate conclusions for a whole subpopulation. These findings were limited to sample size, participant interest and age-range availability within the clinic.
ContributorsGonzalez, Alereese (Author) / Chisum, Jack (Thesis director) / Brown, Glenn (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05