Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 6 of 6
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- All Subjects: Genetics
- All Subjects: Poetry
- Creators: School of Mathematical and Natural Sciences
Description
Veterans are approximately 30% more likely than non-veterans to suffer from severe hearing impairment. Tinnitus, or ringing in the ears, which is increasingly common among military service men and women, has been linked to significant cognitive and psychological impairment and can be worsened by the same sounds that trigger post-traumatic stress disorder (PTSD). In fact, tinnitus and PTSD often present as comorbidities, and recent studies suggest these two disorders may share a common neurological pathway. Additional studies are required to better understand the connection between hearing loss and impaired cognitive function such as that observed in with PTSD. Here, we use the fruit fly, Drosophila melanogaster, to explore the relationship between hearing loss and cognitive function. Negative geotaxis climbing assays and courtship behavior analysis were used to examine neurobehavioral changes induced by prolonged, intense auditory stimulation. Preliminary results suggest that exposure to loud noise for an extended period of time significantly affected Drosophila behavior, with males being more sensitive than females. Based on our results, there appears to be a potential connection between noise exposure and behavior, further suggesting that Drosophila could be an effective model to study the link between hearing loss and PTSD.
ContributorsMichael, Allison Faye (Author) / Hackney-Price, Jennifer (Thesis director) / Sellner, Erin (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Virtually all animals require relatively predictable developmental schedules in order to fulfill the cycle of life. Cell death and severe inflammation alter steroid hormone production and can disrupt the timing of developmental transitions such as puberty. In the fruit fly, Drosophila melanogaster, injury to wing precursor tissues has been shown to result in decreased steroid hormone levels and delay development. The effects of damage to other tissues have not yet been explored. Here, the larval salivary glands were damaged in order to observe how injuring these specific tissues affect the timing of developmental transitions. Damage was induced by tissue-specific, temperature sensitive activation of cell death genes. The results indicated that death to salivary gland cells accelerates the Drosophila time to adult eclosion and that the observed acceleration of development is age-dependent. Insight into the effects of injury on development in Drosophila can potentially lead to information about development in other organisms, including humans, following injury or chronic inflammation.
ContributorsRippere, Alicia Leann (Author) / Hackney, Jennifer (Thesis director) / Marshall, Pamela (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2015-05
Description
With the advent of sophisticated computer technology, we increasingly see the use of computational techniques in the study of problems from a variety of disciplines, including the humanities. In a field such as poetry, where classic works are subject to frequent re-analysis over the course of years, decades, or even centuries, there is a certain demand for fresh approaches to familiar tasks, and such breaks from convention may even be necessary for the advancement of the field. Existing quantitative studies of poetry have employed computational techniques in their analyses, however, there remains work to be done with regards to the deployment of deep neural networks on large corpora of poetry to classify portions of the works contained therein based on certain features. While applications of neural networks to social media sites, consumer reviews, and other web-originated data are common within computational linguistics and natural language processing, comparatively little work has been done on the computational analysis of poetry using the same techniques. In this work, I begin to lay out the first steps for the study of poetry using neural networks. Using a convolutional neural network to classify author birth date, I was able to not only extract a non-trivial signal from the data, but also identify the presence of clustering within by-author model accuracy. While definitive conclusions about the cause of this clustering were not reached, investigation of this clustering reveals immense heterogeneity in the traits of accurately classified authors. Further study may unpack this clustering and reveal key insights about how temporal information is encoded in poetry. The study of poetry using neural networks remains very open but exhibits potential to be an interesting and deep area of work.
ContributorsGoodloe, Oscar Laurence (Author) / Nishimura, Joel (Thesis director) / Broatch, Jennifer (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The culture surrounding death in America is one of science and silence. When possible, death is hidden away from the public view. When exposure to death is unavoidable, it is sensationalized, made into a spectacle. Our dying are put into hospice care, nursing homes, and other hidden spaces, or else they are plastered over the news and internet. So, we get one of two views of death: the sterile, silent death that happens in the presence of medical professionals or the bloody, tragic deaths that are constantly reported across news outlets and social media or sensationalized on entertainment platforms such as movies and video games. Entire genres of television and movies are created on the foundation of bloody deaths and we are exposed to the concept of death constantly.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
ContributorsSandoval, Alicia Rose (Author) / Kobojek, Kimberly (Thesis director) / Watrous, Lisa (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
The need for new tuberculocidal drugs is crucial with drug resistance on the rise as the tuberculosis epidemic rages on. One new potential drug target is the PrrAB two component system (TCS) since it does not exist in humans and is essential to viability in Mycobacterium tuberculosis. This project examines Mycobacterium smegmatis, and this nonpathogenic and fast-growing organism possesses two full length PrrAB orthologs, in addition to an orphaned PrrB sensor histidine kinase. While it was determined that PrrAB1 and PrrAB2 are nonessential, the lone PrrB3 is not yet characterized for essentiality. To confirm individual dispensability of PrrAB1 and PrrAB2 and investigate the essentiality of PrrB3 and the full M. smegmatis PrrAB multiplex, we utilized CRISPRi dCas9 to repress the expression (knockdown) of prrAB1 (MSMEG_5662-5663), prrAB2 (MSMEG_0244-0246), and the lone prrB3 (MSMEG_2793) in M. smegmatis independently and simultaneously. Repression of prrAB1 resulted in the greatest growth defect, with a lag of 17 cellular division cycles compared to the control, a strain generated with an empty vector. However, the knockdown of prrAB1 was not lethal to M. smegmatis. The inhibition of all three prrAB orthologs simultaneously, also known as a multiplex knockdown, lagged the control by 13 cellular division cycles. At the 48-hour point, both the single ortholog repression of prrAB1 as well as the whole prrAB system knockdown had a growth defect of 13 replication cycles behind the control. However, the multiplex knockdown stabilized growth at 48 hours, revealing a possible compensatory mechanism in M. smegmatis. Conclusively, we show that the PrrAB TCS is globally inessential for viability in M. smegmatis.
ContributorsHeiligenstein, Piper (Author) / Haydel, Shelley (Thesis director) / Shrivastava, Abhishek (Committee member) / Haller, Yannik (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2023-12
Description
The use of genetic management in conservation has sparked much debate around the ethical and environmental impacts of the plans. A case study on the conservation of leopard frogs in Arizona was analyzed to better understand the benefits and issues surrounding genetic management plans. The first part of the case focuses on the recent management plan for Chiricahua Leopard Frogs implemented by the Arizona Game and Fish Department. The goal of the plan is to better understand the genetic dynamics of the established Chiricahua Leopard Frog populations to develop a more effective management plan. The second part of the case focuses on the Arizona Game and Fish Department’s management of the Northern Leopard Frog. There was little success with the initial breed and release program of the native species, however a nonnative subspecies of Northern Leopard Frog was able to establish a thriving population. This case study exemplifies the many complications with genetic management plans and the importance of careful assessment of options when deciding on a genetic management plan. Despite the complexity of genetic management plans, it is an important method to consider when discussing the conservation of a species.
ContributorsTurpen, Alexa (Author) / Murphree, Julie (Thesis director) / Collins, James (Thesis director) / Owens, Audrey (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / College of Integrative Sciences and Arts (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2024-05