Barrett

Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

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Hyperactive ERK/MAPK Regulates Cortical GABAergic Neuron Development

Description
Aberrant signaling through the canonical RAS/RAF/MEK/ERK (ERK/MAPK) pathway leads to the pathology of a group of neurodevelopmental disorders called RASopathies. RASopathies are caused by germline mutations in the ERK/MAPK pathway and have an incidence of approximately 1:2000 births. The majority of RASopathies stem from mutations that cause gain-of-function in the…

Aberrant signaling through the canonical RAS/RAF/MEK/ERK (ERK/MAPK) pathway leads to the pathology of a group of neurodevelopmental disorders called RASopathies. RASopathies are caused by germline mutations in the ERK/MAPK pathway and have an incidence of approximately 1:2000 births. The majority of RASopathies stem from mutations that cause gain-of-function in the ERK/MAPK pathway. In this study, we have begun to unravel the roles that GABAergic interneurons play in the pathology of RASopathies. Our data demonstrate that gain-of-function ERK/MAPK signaling expressed in a GABAergic interneuron-specific fashion leads to forebrain hyperexcitability in mutant mice. Further, some GABAergic interneurons experience activated-caspase 3 mediated apoptosis in the embryonic subpallium, leading to a loss of PV-expressing interneurons in the somatosensory cortex. We found that pharmaceutical intervention during embryogenesis using a MEK1 inhibitor may be effective in preventing apoptosis of these neurons. Future work is still needed to understand the mechanism of the death of GABAergic interneurons and to further pursue therapeutic approaches. Taken together, this study suggests potential roles of cortical GABAergic interneurons in ERK/MAPK-linked pathologies and indicates possible approaches to provide therapy for these conditions.
ContributorsShah, Shiv (Author) / Newbern, Jason (Thesis director) / Gipson-Reichardt, Cassandra (Committee member) / School of Life Sciences (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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The Business Venture Approach to Alleviating Poverty: What is the Bottom of the Pyramid Solution and Can It Work?

Description
Billions of people around the world deal with the struggles of poverty every day. Consequently, a number of others have committed themselves to help alleviate poverty. Many various methods are used, and a current consensus on the best method to alleviate poverty is lacking. Generally the methods used or researched…

Billions of people around the world deal with the struggles of poverty every day. Consequently, a number of others have committed themselves to help alleviate poverty. Many various methods are used, and a current consensus on the best method to alleviate poverty is lacking. Generally the methods used or researched exist somewhere on the spectrum between top-down and bottom-up approaches to fighting poverty. This paper analyzes a specific method proposed by C.K. Prahalad known as the Bottom of the Pyramid solution. The premise of the method is that large multinational corporations should utilize the large conglomerate of money that exists amongst poor people \u2014 created due to the sheer number of poor people \u2014 for business ventures. Concurrently, the poor people can benefit from the company's entrance. This method has received acclaim theoretically, but still needs empirical evidence to prove its practicality. This paper compares this approach with other approaches, considers international development data trends, and analyzes case studies of actual attempts that provide insight into the approach's potential for success. The market of poor people at the bottom of the pyramid is extremely segmented which makes it very difficult for large companies to financially prosper. It is even harder to establish mutual benefit between the large corporation and the poor. It has been found that although aspects of the bottom of the pyramid method hold merit, higher potential for alleviating poverty exists when small companies venture into this space rather than large multinational corporations. Small companies can conform to a single community and niche economy to prosper \u2014 a flexibility that large companies lack. Moving forward, analyzing the actual attempts provides the best and only empirical insights; hence, it will be important to consider more approaches into developing economies as they materialize.
ContributorsSanchez, Derek Javier (Author) / Henderson, Mark (Thesis director) / Shunk, Dan (Committee member) / Industrial, Systems (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Haiti in Turmoil: Why US Foreign aid has not worked and how to fix it

Description

Countries such as Haiti—where corruption, violence, and extreme poverty hinder economic growth and recovery— require multifaceted, interdisciplinary solutions. The United States, along with much of the western world, has a flawed understanding of foreign aid. Though current humanitarian efforts have effectively improved the lives of millions of Haitians, they fail…

Countries such as Haiti—where corruption, violence, and extreme poverty hinder economic growth and recovery— require multifaceted, interdisciplinary solutions. The United States, along with much of the western world, has a flawed understanding of foreign aid. Though current humanitarian efforts have effectively improved the lives of millions of Haitians, they fail to address the systemic roots of Haiti’s issues. Likewise, some efforts have been counterproductive or even harmful. If the US wishes to assist Haiti (and similar developing countries for that matter) in its journey to restoring the rule of law, reducing corruption, and empowering its citizens, it must collaborate with Haitian leaders and prioritize socioeconomic policy programs.
ContributorsSteiner, Bennett (Author) / O'Donnell, Edward (Thesis director) / Datta, Manjira (Thesis director) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor) / Economics Program in CLAS (Contributor)
Created2022-05
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Universal Basic Income: Changing the Narrative in the United States

Description
To address the costs of Universal Basic Income (UBI) implementation while promoting new perspectives and broader thinking.

This paper will introduce UBI as a concept and a program to better understand its implementation around the world and the underlying theory of how to afford its sustained use. The paper examines several…

To address the costs of Universal Basic Income (UBI) implementation while promoting new perspectives and broader thinking.

This paper will introduce UBI as a concept and a program to better understand its implementation around the world and the underlying theory of how to afford its sustained use. The paper examines several different implementation and funding mechanisms that are all focused on economic growth as the sole measure of success. It displays how UBI's program costs make it insufficient for further use under those metrics. This paper introduces the need to change the narrative to focus less on GDP-growth and more about the positive benefits of income distribution to raise the poverty line, decrease income inequality, and increase the overall well-being of each citizen in the United States.
ContributorsGordon, Chandler Robert (Author) / Hill, Alexander (Thesis director) / Wong, Kelvin (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05