Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

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Description
An introduction to neuroscientific thought aimed at an audience that is not educated in biology. Meant to be readable and easily understood by anyone with a high school education. The first section is completed in its entirety, with outlines for the proposed final sections to be completed over the next

An introduction to neuroscientific thought aimed at an audience that is not educated in biology. Meant to be readable and easily understood by anyone with a high school education. The first section is completed in its entirety, with outlines for the proposed final sections to be completed over the next few years.
ContributorsNelson, Nicholas Alan (Author) / Olive, M. Foster (Thesis director) / Brewer, Gene (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2014-05
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Description
There is preclinical evidence that the detrimental cognitive effects of hormone loss can be ameliorated by estrogen therapy (Bimonte, Acosta, & Talboom, 2010), however, one of the primary concerns with current hormone therapies is that they are nonselective, leading to increased risk of breast and endometrial cancers as well as

There is preclinical evidence that the detrimental cognitive effects of hormone loss can be ameliorated by estrogen therapy (Bimonte, Acosta, & Talboom, 2010), however, one of the primary concerns with current hormone therapies is that they are nonselective, leading to increased risk of breast and endometrial cancers as well as heart disease. Thus, in order to achieve a successful and clinically relevant long-term hormone therapy option, it is optimal to find an estrogen therapy regimen that is selective to its target tissue. Recently, phytoestrogens have been found to exert selective, beneficial effects on cognition and brain. For example, genistein and diadzein produce neuroprotective effects in cognitive brain regions (Zhao, Chen, & Diaz Brinton, 2002). The purpose of this study was threefold: 1) to examine the cognitive impact of phytoestrogens in young ovariectomized rats, 2) to replicate the dose effects found in the Luine study (Luine et al., 2006), while controlling for manufacturer differences, and 3) to assess if the rodent diet used in our laboratory has an estrogenic-like cognitive impact.The current findings suggest that, at least for object memory, diets containing varying amounts of phytoestrogens can alter cognition, with diets containing high amounts of phytoestrogens showing potential benefits to this type of memory.
ContributorsWhitton, Elizabeth Nicole (Author) / Bimonte-Nelson, Heather (Thesis director) / Presson, Clark (Committee member) / Baxter, Leslie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2013-05
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Description
Mobile technology has introduced a new opportunity for students with autism spectrum disorder to communicate. Tablets, like the iPad, allow the users to customize applications for their needs. Users have also found iPads to be less stigmatizing because so many people own them and use them for various purposes. In

Mobile technology has introduced a new opportunity for students with autism spectrum disorder to communicate. Tablets, like the iPad, allow the users to customize applications for their needs. Users have also found iPads to be less stigmatizing because so many people own them and use them for various purposes. In the fast-paced world of technology, however, research cannot always keep up. It is becoming more important for the teachers and caregivers to evaluate the iPad and its applications for their efficacy in helping improve the child's communication skills. After a thorough review of current research on app use in educational settings, five criteria for evaluating app quality emerged. These criteria are: the ability to customize the application, the motor skills the student needs to operate the system, the resources and time needed for the intervention, the research or evidence-based practices behind the application, and the cost of using this device. The website, Apps For ASD, was created to provide teachers with this resource material.
ContributorsBoyd, Tara Katherine (Author) / Hart, Juliet (Thesis director) / Farr, Wendy (Committee member) / Gehrke, Rebecca (Committee member) / Barrett, The Honors College (Contributor) / College of Public Works (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor)
Created2013-12
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Description
Cocaine is a highly addictive psychostimulant that is widely used around the world. It is far more cost effective to curb this problem through treatment than by any other method as medicinal drug treatment is 15 times more effective than law enforcement at reducing the societal costs of cocaine use

Cocaine is a highly addictive psychostimulant that is widely used around the world. It is far more cost effective to curb this problem through treatment than by any other method as medicinal drug treatment is 15 times more effective than law enforcement at reducing the societal costs of cocaine use as determine by RAND corp. In a previous paper from our lab, it was found that via virally mediated introduction of additional 5-HT1B receptors into the nucleus accumbens there was a leftward shift in the cocaine intake dose-response curve in animals that were self-administering cocaine by pressing a lever. These findings suggest that 5-HT1B receptor action enhances the reinforcing effects of cocaine. However, when animals were given a 21-day period of prolonged abstinence and then tested for cocaine intake, it was determined that 5-HT1B receptor action had the opposite effect of decreasing cocaine intake presumably due to a decrease in the reinforcing effects of cocaine: [16]. The experiment in the current paper was devised to further test this finding via pharmacological means using the 5-HT1B agonist CP 94253 to increase stimulation of 5-HT1B receptors. Animals were trained to self-administer by pressing a lever on fixed ratio schedules of cocaine reinforcement given at 0.75 mg/kg and 0.075 mg/kg doses of cocaine. These doses allowed us to examine changes in self-administration on both the ascending and descending limbs of the inverted u-shaped cocaine dose-effect curve. Our results indicated that in animals given CP 94253 exhibited a decrease in responding on both the ascending and descending limbs of the dose response curve demonstrating a downward shift after prolonged abstinence. These exciting results suggest that the agonist decreases cocaine intake, and therefore, the agonist may be a useful treatment for cocaine dependence.
ContributorsYanamandra, Krishna Teja (Author) / Neisewander, Janet (Thesis director) / Goldstein, Elliott (Committee member) / Pentkowski, Nathan (Committee member) / Barrett, The Honors College (Contributor)
Created2013-05
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Description
Research regarding social skills training techniques for youth with autism spectrum disorders does not generally include implementation in anywhere but clinical, highly structured settings. However, leisure and recreation settings are conducive to promoting social skills improvement due to assets such as typical peer groups, engaging play activities, and significant opportunities

Research regarding social skills training techniques for youth with autism spectrum disorders does not generally include implementation in anywhere but clinical, highly structured settings. However, leisure and recreation settings are conducive to promoting social skills improvement due to assets such as typical peer groups, engaging play activities, and significant opportunities for incidental learning. This program was designed for this particular population and integrated in to the daily schedule of a six-week long therapeutic recreation summer day camp for adolescents with disabilities ages 13-18. A standardized assessment, the Home and Community Social Behavior Scales (HCSBS) evaluates various areas of social ability and was utilized to measure changes specifically in peer interaction skills of participants with autism. Results discovered that this design can complement the aims of the camp and contribute to social enrichment and inclusion; every subject showed positive gains in the peer relations subscale at a much higher rate than in any other area of social ability. Multiple recognizable patterns emerged that can be evaluated in future studies, including greater average improvements for females, those ages 16-18 and those with an Asperger's diagnosis. Replication of this program could quantify and confirm the effectiveness of social skills training within recreation, which would require controlling for the additional treatment of a therapeutic summer camp. However, this observational case study demonstrates a promising future regarding improving the efficiency and value of therapeutic recreation services for adolescents with autism spectrum disorders.
ContributorsPugh, Tara Morgan (Author) / Rodriguez, Ariel (Thesis director) / Ramella, Kelly (Committee member) / Herron, Brad (Committee member) / Barrett, The Honors College (Contributor) / School of Community Resources and Development (Contributor)
Created2014-12
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Description
Environmental and genetic factors contribute to schizophrenia etiology, yet few studies have demonstrated how environmental stimuli impact genes associated with the disorder. Immediate early genes (IEGs) are of great interest to schizophrenia research because they are activated in response to physiological stress from the environment, and subsequently regulate the expression

Environmental and genetic factors contribute to schizophrenia etiology, yet few studies have demonstrated how environmental stimuli impact genes associated with the disorder. Immediate early genes (IEGs) are of great interest to schizophrenia research because they are activated in response to physiological stress from the environment, and subsequently regulate the expression of downstream genes that are essential to neuropsychiatric function. An IEG, early growth response 3 (EGR3) has been identified as a main gene involved in a network of transcription factors implicated in schizophrenia susceptibility. The serotonin 2A receptor (5-HT2AR) seems to play an important role in schizophrenia and the dysfunction of the 5-HT2AR encoding gene, HTR2A, within the prefrontal cortex (PFC) contributes to multiple psychiatric illnesses including schizophrenia. EGR3's role as a transcription factor that is activated by environmental stimuli suggests it may regulate Htr2a transcription in response to physiological stress, thus affecting 5-HT2AR function in the prefrontal cortex (PFC). The aim of this study was to examine the relationship between Egr3 activation and Htr2a expression after an environmental stimulus. Sleep deprivation is an acute physiological stressor that activates Egr3. Therefore to examine the relationship between Egr3 and Htr2a expression after an acute stress, wild type and Egr3 knockout mice that express EGFP under the control of the Htr2a promoter were sleep deprived for 8 hours. We used immunohistochemistry to determine the location and density of Htr2a-EGFP expression after sleep deprivation and found that Htr2a-EGFP expression was not affected by sex or subregions of the PFC. Additionally, Htr2a-EGFP expression was not affected by the loss of Egr3 or sleep deprivation within the PFC. The LPFC subregions, layers V and VI showed significantly more Htr2a-EGFP expression than layers I-III in all animals for both sleep deprivation and control conditions. Possible explanations for the lack of significant effects in this study may be the limited sample size or possible biological abnormalities in the Htr2a-EGFP mice. Nonetheless, we did successfully visualize the anatomical distribution of Htr2a in the prefrontal cortex via immunohistochemical staining. This study and future studies will provide insight into how Egr3 activation affects Htr2a expression in the PFC and how physiological stress from the environment can alter candidate schizophrenia gene function.
ContributorsSabatino, Alissa Marie (Author) / Gallitano, Amelia (Thesis director) / Hruschka, Daniel (Thesis director) / Maple, Amanda (Committee member) / Barrett, The Honors College (Contributor)
Created2014-05
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Description

This research paper covers many topics related to autism, including causes, treatment, DSM changes, and more. It is a review of current literature and journals and aims to give the audience a better understanding of the disorders and to discuss the changes in diagnostic criteria and prevalence of ASD.

ContributorsPeters, Emily Morgan (Author) / Stenhoff, Donald (Thesis director) / Hahs, Adam (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Autism Spectrum Disorder (ASD) is a developmental disability that impacts one’s social interaction, communication skills (both verbal and non-verbal), and cognitive function. Autism affects 1 in 60 children. Individuals with autism have trouble understanding facial expressions or social cues, and often see the world around them differently than a neurotypical

Autism Spectrum Disorder (ASD) is a developmental disability that impacts one’s social interaction, communication skills (both verbal and non-verbal), and cognitive function. Autism affects 1 in 60 children. Individuals with autism have trouble understanding facial expressions or social cues, and often see the world around them differently than a neurotypical individual (mainly increased sensitivity to sounds, motion, or lighting). As the name implies, autism is a spectrum, and no two individuals are alike. As the saying goes, “When you’ve met one person with autism, you’ve met one person with autism.” Movies such as Rain Man (1988) or The Accountant (2016) showcase autistic individuals who are higher-functioning; they are able to verbally communicate and live somewhat independently. Other autistic individuals, such as my brother, Tyler, are lower-functioning. Tyler is non-verbal and unable to be independent, and our day-to-day life is greatly shaped by this.<br/><br/>One thought that haunts the parents of autistic individuals is, “What happens when they’re older?” Even more scary is the question “What will happen when I’m gone?” My brother is on the autism spectrum, and my mother describes these thoughts as ones that “keep [her] up at night.” She explains, “I think it’s important for him to be completely engaged and productive, and we have that right now because we’re in our little safety bubble...that’s going to end...and it’s kind of scary.” Around 50,000 children with autism turn 18 every year in the United States, and nearly 90% of autistic individuals lose access to the services they have relied on throughout their entire lives. My hope is that architecture can help to answer this question by providing a place for adults on the autism spectrum to learn how to eventually live and work independently in the future. By implementing certain design features and design criteria to minimize the sensory overload issues commonly experienced by individuals with autism, we can create a safe space for learning for young adults on the autism spectrum.

ContributorsSobelman, Jacob Evan (Author) / Zingoni, Milagros (Thesis director) / Hejduk, Renata (Committee member) / Patel, Tina (Committee member) / School of Geographical Sciences and Urban Planning (Contributor) / The Design School (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The aim of this study was to explore cross-sectional and longitudinal aging differences in immediate and delayed visual and verbal memory abilities in individuals with Autism Spectrum Disorder (ASD) compared with neurotypicals (NTs). We measured hippocampal size, fornix fractional anisotropy (FA), and hippocampal and fornix freewater to understand how aging

The aim of this study was to explore cross-sectional and longitudinal aging differences in immediate and delayed visual and verbal memory abilities in individuals with Autism Spectrum Disorder (ASD) compared with neurotypicals (NTs). We measured hippocampal size, fornix fractional anisotropy (FA), and hippocampal and fornix freewater to understand how aging impacts memory structures. Longitudinal findings highlight vulnerabilities in immediate verbal memory and hippocampal volume, while cross-sectional findings indicate fornix freewater may increase at a faster rate in adults with ASD. Future research will examine cognitive and structural sex differences and will study how cognitive measures correlate with structural measures.

ContributorsSullivan, Georgia Rose (Author) / Braden, B. Blair (Thesis director) / Ofori, Edward (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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One obstacle which children with autism spectrum disorders (ASDs) face when learning in a public-school environment is the lack of feeling included when learning. In this study, the term inclusion refers to time that children with ASDs spend in general education settings, interacting and/or engaging with neurotypical students and teachers.

One obstacle which children with autism spectrum disorders (ASDs) face when learning in a public-school environment is the lack of feeling included when learning. In this study, the term inclusion refers to time that children with ASDs spend in general education settings, interacting and/or engaging with neurotypical students and teachers. Inclusion can help students with ASDs improve their social skills, as well as academic achievement, mental health, and future success (Camargo et al., 2014). Since children with ASDs often have difficulties with social interaction skills, this can prevent their successful inclusion in general education placements. Music is a type of behaviorally-based intervention, which has proven to be effective in helping students develop the skills necessary to be successfully included, and because it is a type of activity which can serve as a bit of a distraction from the social aspect of the interaction, it can help children practice social skills and interact in a comfortable way. This study examines how music is used in public school settings to help foster the skills necessary for autistic children to be involved in standard school curriculums in order to allow them to receive the full benefits from learning in a general education setting. This study was conducted by reviewing past literature on the benefits of inclusion in special education, the benefits of music for children with ASDs, and the difference in efficacy of music interventions when conducted in an inclusive setting. Interviews with special education teachers, music educators, and music therapists were also conducted to address examples of the impact of music in this research area. The study found that music is beneficial in allowing more students to be included in standard school curriculums, and data showed the trend that inclusion positively affected their social and academic development.

ContributorsVerma, Alisha (Author) / Kappes, Janelle (Thesis director) / Ruiz, Eugenia Hernandez (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05