Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- All Subjects: adolescents
- Creators: Liss, Tyler Jessee
- Creators: Loebenberg, Abby
Description
High fat diets (HFD) are known to cause hepatic non-alcoholic steatosis in rats in as few as four weeks. Accumulation of triglycerides in liver and skeletal muscle is associated with insulin resistance and obesity. However, studies of fat accumulation in cardiac muscle are not as prevalent. Therefore, the first hypothesis of this study was that HFD would lead to hepatic steatosis as well as lipid accumulation in pectoralis and cardiac muscles, tissues responsible for the majority of postprandial glucose disposal. Prior studies also indicated that HFD leads to increased inflammation and oxidative stress within the vasculature resulting in impaired endothelium-dependent vasodilation, however biomarkers of immune system reactivity were not assessed. Therefore, the second aim of this study was to explore additional pathways of immune system reactivity and stress (natural antibodies; heat shock protein 60 (HSP60)) in rats fed either a control (chow) or high fat (HFD) diet. HSP60 has also recently been recognized as an early marker of vascular dysfunction in humans. The hypothesis was that immune system reactivity and early vascular dysfunction would be heightened in rats fed a HFD compared to chow-fed controls. Young male Sprague-Dawley rats (140-160g) were maintained on a chow diet (5% fat, 57.33% carbohydrate, 3.4kcal/g) or HFD (60% fat, 20% carbohydrate, 5.24 kcal/g) for 6 weeks. HFD rats developed hepatic steatosis with significantly elevated liver triglyceride concentrations compared to chow-fed controls (20.73±2.09 vs.9.75±0.52 mg triglycerides/g tissue, respectively; p=0.001). While lipid accumulation appeared to be evident in the pectoralis muscle from HFD rats, triglyceride concentrations were not significantly different from controls. Likewise, there was no evidence of lipid infiltration in cardiac muscles of HFD rats. Lipid accumulation in the liver of overweight HFD rats may contribute to the observed insulin resistance in these animals. Contrary to the second hypothesis, there were no significant differences in plasma HSP60 expression between HFD and chow rats (p>0.05). Likewise, hemagglutination and hemolysis responses were similar between HFD and chow-fed rats (p>0.05). These findings suggest that immune system responses may not be affected by 6 weeks of high fat intake and that HSP60 is not an early marker of vascular dysfunction in this rodent model.
ContributorsLiss, Tyler Jessee (Author) / Sweazea, Karen (Thesis director) / Shaibi, Gabriel (Committee member) / Johnston, Carol (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2013-05
Communicating with Confidence: Evaluating Sexual Education Exposure’s Effect on Sexual Communication
Description
This study examined associations between reports of receiving information on sexual education topics common to different sexual education curricula (e.g. abstinence only until marriage, comprehensive) and reported confidence in sexual communication of information and preferences, taking into account information received from school health classes, parents/guardians, online resources, and peers.
Data used from 293 participants aged 18-25 was used to perform descriptive analyses and linear regressions adjusted for significant covariates. Exposure to a comprehensive sexual education curriculum was found to be significantly positively associated with increased sexual communication confidence, while exposure to an abstinence only until marriage curriculum was not found to be a significant predictor. All resources were found to be positively associated with sexual communication confidence with the exception of health class, which was an insignificant predictor.
Comprehensive sexual education is an important factor in increasing young adults’ confidence in sexual communication of information and preferences. However, sexual education delivery in health classes in the United States is currently ineffective. A reevaluation of how sexual education should be delivered in the United States is needed.
Data used from 293 participants aged 18-25 was used to perform descriptive analyses and linear regressions adjusted for significant covariates. Exposure to a comprehensive sexual education curriculum was found to be significantly positively associated with increased sexual communication confidence, while exposure to an abstinence only until marriage curriculum was not found to be a significant predictor. All resources were found to be positively associated with sexual communication confidence with the exception of health class, which was an insignificant predictor.
Comprehensive sexual education is an important factor in increasing young adults’ confidence in sexual communication of information and preferences. However, sexual education delivery in health classes in the United States is currently ineffective. A reevaluation of how sexual education should be delivered in the United States is needed.
ContributorsDouglass, Kathryn (Author) / Pivovarova, Margarita (Thesis director) / Loebenberg, Abby (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12