Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- All Subjects: Identity
- All Subjects: Alzheimer's Disease
Description
Alzheimer’s Disease (AD) affects over 5 million individuals in the U.S. and has a direct cost estimated in excess of $200 billion per year. Broadly speaking, there are two forms of AD—early-onset, familial AD (FAD) and late-onset-sporadic AD (SAD). Animal models of AD, which rely on the overexpression of FAD-related mutations, have provided important insights into the disease. However, these models do not display important disease-related pathologies and have been limited in their ability to model the complex genetics associated with SAD.
Advances in cellular reprogramming, have enabled the generation of in vitro disease models that can be used to dissect disease mechanisms and evaluate potential therapeutics. To that end, efforts by many groups, including the Brafman laboratory, to generated patient-specific hiPSCs have demonstrated the promise of studying AD in a simplified and accessible system. However, neurons generated from these hiPSCs have shown some, but not all, of the early molecular and cellular hallmarks associated with the disease. Additionally, phenotypes and pathological hallmarks associated with later stages of the human disease have not been observed with current hiPSC-based systems. Further, disease relevant phenotypes in neurons generated from SAD hiPSCs have been highly variable or largely absent. Finally, the reprogramming process erases phenotypes associated with cellular aging and, as a result, iPSC-derived neurons more closely resemble fetal brain rather than adult brain.
It is well-established that in vivo cells reside within a complex 3-D microenvironment that plays a significant role in regulating cell behavior. Signaling and other cellular functions, such as gene expression and differentiation potential, differ in 3-D cultures compared with 2-D substrates. Nonetheless, previous studies using AD hiPSCs have relied on 2-D neuronal culture models that do not reflect the 3-D complexity of native brain tissue, and therefore, are unable to replicate all aspects of AD pathogenesis. Further, the reprogramming process erases cellular aging phenotypes. To address these limitations, this project aimed to develop bioengineering methods for the generation of 3-D organoid-based cultures that mimic in vivo cortical tissue, and to generate an inducible gene repression system to recapitulate cellular aging hallmarks.
Advances in cellular reprogramming, have enabled the generation of in vitro disease models that can be used to dissect disease mechanisms and evaluate potential therapeutics. To that end, efforts by many groups, including the Brafman laboratory, to generated patient-specific hiPSCs have demonstrated the promise of studying AD in a simplified and accessible system. However, neurons generated from these hiPSCs have shown some, but not all, of the early molecular and cellular hallmarks associated with the disease. Additionally, phenotypes and pathological hallmarks associated with later stages of the human disease have not been observed with current hiPSC-based systems. Further, disease relevant phenotypes in neurons generated from SAD hiPSCs have been highly variable or largely absent. Finally, the reprogramming process erases phenotypes associated with cellular aging and, as a result, iPSC-derived neurons more closely resemble fetal brain rather than adult brain.
It is well-established that in vivo cells reside within a complex 3-D microenvironment that plays a significant role in regulating cell behavior. Signaling and other cellular functions, such as gene expression and differentiation potential, differ in 3-D cultures compared with 2-D substrates. Nonetheless, previous studies using AD hiPSCs have relied on 2-D neuronal culture models that do not reflect the 3-D complexity of native brain tissue, and therefore, are unable to replicate all aspects of AD pathogenesis. Further, the reprogramming process erases cellular aging phenotypes. To address these limitations, this project aimed to develop bioengineering methods for the generation of 3-D organoid-based cultures that mimic in vivo cortical tissue, and to generate an inducible gene repression system to recapitulate cellular aging hallmarks.
ContributorsBounds, Lexi Rose (Author) / Brafman, David (Thesis director) / Wang, Xiao (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This Barrett, the Honors College senior thesis connects the experiences of cosplay with public speaking confidence. “Cosplay, abbreviated from the word ‘costume play,’ is a performance art in which the participant masquerades as a character from a selected film, television, video game, or comic book” (Gn, 2011, p. 583). The ability to “cosplay” in front of other relies on performing in front of an audience much like public speaking. When students speak with confidence, students will know their ideas are being expressed with conviction and assurance. Having the ability to speak professionally and publicly, is a highly valued skill in the workforce and key to success in all types of employment. Communication skills are frequently a top factor in determining whether a college student will obtain employment (Beebe & Beebe, 2006, p. 275-276). Despite their different definitions, there are multiple connections between cosplay and public speaking. This thesis explores the connection between peer support and belief in one’s self in both cosplay and public speaking. Now those who have direct support become self-reliant and confident as a result of these connections. This projects highlights Goffman’s identity theory, the Pygmalion effect, theories of fashion and identity, role-play, narrative paradigm, dramatism, and non-verbal communication, and explores how cosplay can contribute to the formation of one’s public speaking persona. The issue of anxiety is also included in the conversation as it is central to both cosplay and public speaking. Ultimately, this thesis explores the questions: Can cosplay help students become empowered public speakers?
ContributorsGallardo Rojas, Lizette (Author) / Ramsey, Ramsey Eric (Thesis director) / Wentzel, Bonnie (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Criminology and Criminal Justice (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Background: Noninvasive MRI methods that can accurately detect subtle brain changes are highly desirable when studying disease-modifying interventions. Texture analysis is a novel imaging technique which utilizes the extraction of a large number of image features with high specificity and predictive power. In this investigation, we use texture analysis to assess and classify age-related changes in the right and left hippocampal regions, the areas known to show some of the earliest change in Alzheimer's disease (AD). Apolipoprotein E (APOE)'s e4 allele confers an increased risk for AD, so studying differences in APOE e4 carriers may help to ascertain subtle brain changes before there has been an obvious change in behavior. We examined texture analysis measures that predict age-related changes, which reflect atrophy in a group of cognitively normal individuals. We hypothesized that the APOE e4 carriers would exhibit significant age-related differences in texture features compared to non-carriers, so that the predictive texture features hold promise for early assessment of AD. Methods: 120 normal adults between the ages of 32 and 90 were recruited for this neuroimaging study from a larger parent study at Mayo Clinic Arizona studying longitudinal cognitive functioning (Caselli et al., 2009). As part of the parent study, the participants were genotyped for APOE genetic polymorphisms and received comprehensive cognitive testing every two years, on average. Neuroimaging was done at Barrow Neurological Institute and a 3D T1-weighted magnetic resonance image was obtained during scanning that allowed for subsequent texture analysis processing. Voxel-based features of the appearance, structure, and arrangement of these regions of interest were extracted utilizing the Mayo Clinic Python Texture Analysis Pipeline (pyTAP). Algorithms applied in feature extraction included Grey-Level Co-Occurrence Matrix (GLCM), Gabor Filter Banks (GFB), Local Binary Patterns (LBP), Discrete Orthogonal Stockwell Transform (DOST), and Laplacian-of-Gaussian Histograms (LoGH). Principal component (PC) analysis was used to reduce the dimensionality of the algorithmically selected features to 13 PCs. A stepwise forward regression model was used to determine the effect of APOE status (APOE e4 carriers vs. noncarriers), and the texture feature principal components on age (as a continuous variable). After identification of 5 significant predictors of age in the model, the individual feature coefficients of those principal components were examined to determine which features contributed most significantly to the prediction of an aging brain. Results: 70 texture features were extracted for the two regions of interest in each participant's scan. The texture features were coded as 70 initial components andwere rotated to generate 13 principal components (PC) that contributed 75% of the variance in the dataset by scree plot analysis. The forward stepwise regression model used in this exploratory study significantly predicted age, accounting for approximately 40% of the variance in the data. The regression model revealed 5 significant regressors (2 right PC's, APOE status, and 2 left PC by APOE interactions). Finally, the specific texture features that contributed to each significant PCs were identified. Conclusion: Analysis of image texture features resulted in a statistical model that was able to detect subtle changes in brain integrity associated with age in a group of participants who are cognitively normal, but have an increased risk of developing AD based on the presence of the APOE e4 phenotype. This is an important finding, given that detecting subtle changes in regions vulnerable to the effects of AD in patients could allow certain texture features to serve as noninvasive, sensitive biomarkers predictive of AD. Even with only a small number of patients, the ability for us to determine sensitive imaging biomarkers could facilitate great improvement in speed of detection and effectiveness of AD interventions..
ContributorsSilva, Annelise Michelle (Author) / Baxter, Leslie (Thesis director) / McBeath, Michael (Committee member) / Presson, Clark (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
In 2012, President Obama presented an executive order, Deferred Action for Childhood Arrivals (DACA), which primarily defers the deportation of unauthorized immigrants who are under the age of 31 and who arrived to the US before the age 16, among other things. This study examines the impact DACA has had on the identity formation, interfamilial relationships, and future plans of 15 Mexican-origin adults (18-27 years old, 47% female) who were approved for DACA in Arizona. Participants were recruited using flyers and the snowball sampling method. Interviews were conducted using a semi-structured interview guide by a bilingual, culturally competent interviewer. The interviews were recorded and then a transcript-based pragmatic, thematic analysis of the interviews was conducted. Findings show that participants who arrive to the U.S. at a younger age (under 5) identify as American, while those who arrive at an older age (over 8) do not feel like they can identify as an American because they spent more time in Mexico and are more attached to their home culture. Physical characteristics also played a factor in whether or not participants felt like they could identify as American. Participants describe their financial responsibility in their families increasing since receiving DACA. They also describe how they are now seen as role models to other undocumented youth in their families. Despite the uncertain future of DACA, these participants continued to have ambitious goals such as becoming lawyers and working at robotics companies. Future studies should include larger sample sizes and formally test theories of identity.
ContributorsLopez, Alejandra (Author) / Diaz McConnell, Eileen (Thesis director) / Martinez, Airin (Committee member) / School of Social Transformation (Contributor) / School of Transborder Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Across the world, nations manage their borders in various ways. Brazil and Uruguay share a non-militarized dry border, which creates a range of unique challenges and assets for that region. Through historical, linguistic, and cultural context as well as ethnography-inspired mixed method research, this paper demonstrates that the border region serves as an area of cultural blending. While elements of national affiliation are still present, at times, semiotic and linguistic elements are neither Brazilian nor Uruguayan, but have taken on their own identity.
ContributorsAraiza, Ulises (Co-author) / Desper, Tate (Co-author) / Escobar, Edward (Thesis director) / O'Connor, Brendan (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Transborder Studies (Contributor)
Created2015-05
Description
The research objective is to maintain the A4 nanobody stability during dialysis. Various dialysis buffers were tested and compared, including PBS with varying amounts of the detergent, Tween: low, high, none. Furthermore, PBS, Tris, and HEPES, were tested and compared. PBS without Tween was the worst for preserving A4 stability. PBS was determined to be a better dialysis buffer than Tris or HEPES. To find the optimum buffer, other buffers will be tested and compared with PBS; methods such as gravity filtration and lyophilization will be considered as alternatives to dialysis.
ContributorsTao, Kevin Huang (Author) / Sierks, Michael (Thesis director) / Williams, Stephanie (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2015-05
Does assisted cycle therapy influence activities of daily living in older adults with Down syndrome?
Description
The aim of this study is to examine the relationship between Assisted Cycle Therapy, leisure time activity levels, fine motor control, and grip force in older adults with Down syndrome (DS), all of which affect activities of daily living (ADL) and therefore quality of life. This is relevant because this particular group is at risk for developing early onset Alzheimer's disease (AD), which presents itself uniquely in this population. The parent or guardian of six participants with DS completed Godin's Leisure Time Exercise Questionnaire and the participants themselves completed Purdue Pegboard and grip force assessments before and after an 8-week exercise intervention. The results were inconsistent with past research, with no change being seen in fine motor control or grip force and a decrease being seen in leisure activity. These findings are indicative of the importance of the effect of fatigue on leisure activity as well as maintaining elevated heart rate throughout exercise interventions.
ContributorsGomez, Elizabeth Danielle (Author) / Ringenbach, Shannon (Thesis director) / Coon, David (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor)
Created2015-05
Description
It took the coming together of a community of people and their collective efforts to bring me where I am today academically. I would first like to thank Barrett, especially Dean Ramsey who helped build my appreciation for reading primary text, and NCUIRE for awarding me the grant for this project. I want to extend my gratitude to Dr. Jeffery Kassing for being more than a director for my thesis by patiently listening to me talk about my future aspiration, and Dr. Jim Reed for being a mentor and a second reader. I would also like to thank all the multitude of professors and other mentors who helped shape my perspective in seeing the bigger picture. I am mostly grateful to all those who directly and indirectly helped bring this thesis to realization. Lastly, but certainly not the least, I would like to say a big thank you to my entire family, loved ones, and friends here and back home for enthusiastically cheering me on.
ContributorsWento, Christiana Tally (Author) / Kassing, Jeffrey (Thesis director) / Reed, James (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
The purpose of this paper will be to show that the 'merge' model of mental files is to be preferred to the 'link' model of mental files because some of the problems that arise for the 'merge' model also arise for the 'link' model, and because the problems for the 'merge' model can be argued against via counterexamples or explained away. This will be shown by giving a detailed description of what both the link model and the merge model of mental files entail. The flaws of the mental file merge model will be presented, followed by the advantages of the link model, ending with several arguments as to why the merge model is better suited to explain our intuitions about identity than the link model.
ContributorsZimmerman, Thomas Scott (Author) / Pinillos, N. Angel (Thesis director) / Kobes, Bernard (Committee member) / Reynolds, Steven (Committee member) / Barrett, The Honors College (Contributor)
Created2015-05
Description
Body Integrity Identity Disorder Screenplay Abstract
The Body Integrity Identity Disorder Screenplay, tentatively entitled Detach, is a full-‐length feature film script. Based on a fascinating mental disorder (generally referred to as the acronym BIID) where an individual does not associate a limb with the rest of their body, the script follows a sufferer and a reporter attempting to write a story on his struggle.
As my creative sensibilities and skills have developed over the span of my undergraduate career, the most ambitious undertaking imaginable for myself at this moment is the completion of a feature script. This project was a significant test of my storytelling skills and ability to format an unusual tale into a conceivable film.
I am proud of the end result and believe that the final version of my screenplay is an accurate representation of my taste as a filmmaker. I hope to actualize this project one day and help facilitate a transformation of the script into a feature film.
The Body Integrity Identity Disorder Screenplay, tentatively entitled Detach, is a full-‐length feature film script. Based on a fascinating mental disorder (generally referred to as the acronym BIID) where an individual does not associate a limb with the rest of their body, the script follows a sufferer and a reporter attempting to write a story on his struggle.
As my creative sensibilities and skills have developed over the span of my undergraduate career, the most ambitious undertaking imaginable for myself at this moment is the completion of a feature script. This project was a significant test of my storytelling skills and ability to format an unusual tale into a conceivable film.
I am proud of the end result and believe that the final version of my screenplay is an accurate representation of my taste as a filmmaker. I hope to actualize this project one day and help facilitate a transformation of the script into a feature film.
ContributorsKitnick, Benjamin Allan (Author) / Bernstein, Gregory (Thesis director) / Miller, April (Committee member) / Barrett, The Honors College (Contributor) / School of Film, Dance and Theatre (Contributor)
Created2015-05