Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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Description
On December 28th 2012, immigration authorities arrested my father and mother while grocery shopping. As soon as they stepped outside, immigration officers stopped them to be questioned. Jeopardizing my university graduation, I took on the challenge to fight court and petition my parents to not be deported. As a first generation born American, I have the power and the right to petition for the freedom of my parents. I was fortunate to be born in this country as a citizen and take advantage of all the opportunities given to me. Up until today, my family and I have done nothing but participate as good citizens. What I failed to realize is that one day our family would become deportation victims of the broken immigration system. There are currently between 11 to12 million undocumented people living in the United States with no pathway to citizenship. My father and mother were humiliated in jail, separated from the family for three months and suffered from emotional distress. It is imperative for me to share our family experience so others know the reality about illegal immigration. In this paper I aspire to leave the reader with knowledge and understanding about illegal immigration. The main purpose of my thesis is to retell my family's experience and the struggle we are still currently facing. The fate of my family was decided on March 25th 2013, and my family has been forever changed. We learned the valuable lesson that as Latinos in the community, we need to fight for freedom and speak on those that are undocumented and afraid.
ContributorsCalderon, Rudy (Author) / Larson, Elizabeth (Thesis director) / Ovando, Carlos (Committee member) / Sanchez, Marta (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of International Letters and Cultures (Contributor)
Created2013-05
Description
Cocaine is a highly addictive psychostimulant that is widely used around the world. It is far more cost effective to curb this problem through treatment than by any other method as medicinal drug treatment is 15 times more effective than law enforcement at reducing the societal costs of cocaine use as determine by RAND corp. In a previous paper from our lab, it was found that via virally mediated introduction of additional 5-HT1B receptors into the nucleus accumbens there was a leftward shift in the cocaine intake dose-response curve in animals that were self-administering cocaine by pressing a lever. These findings suggest that 5-HT1B receptor action enhances the reinforcing effects of cocaine. However, when animals were given a 21-day period of prolonged abstinence and then tested for cocaine intake, it was determined that 5-HT1B receptor action had the opposite effect of decreasing cocaine intake presumably due to a decrease in the reinforcing effects of cocaine: [16]. The experiment in the current paper was devised to further test this finding via pharmacological means using the 5-HT1B agonist CP 94253 to increase stimulation of 5-HT1B receptors. Animals were trained to self-administer by pressing a lever on fixed ratio schedules of cocaine reinforcement given at 0.75 mg/kg and 0.075 mg/kg doses of cocaine. These doses allowed us to examine changes in self-administration on both the ascending and descending limbs of the inverted u-shaped cocaine dose-effect curve. Our results indicated that in animals given CP 94253 exhibited a decrease in responding on both the ascending and descending limbs of the dose response curve demonstrating a downward shift after prolonged abstinence. These exciting results suggest that the agonist decreases cocaine intake, and therefore, the agonist may be a useful treatment for cocaine dependence.
ContributorsYanamandra, Krishna Teja (Author) / Neisewander, Janet (Thesis director) / Goldstein, Elliott (Committee member) / Pentkowski, Nathan (Committee member) / Barrett, The Honors College (Contributor)
Created2013-05
Description
There is preclinical evidence that the detrimental cognitive effects of hormone loss can be ameliorated by estrogen therapy (Bimonte, Acosta, & Talboom, 2010), however, one of the primary concerns with current hormone therapies is that they are nonselective, leading to increased risk of breast and endometrial cancers as well as heart disease. Thus, in order to achieve a successful and clinically relevant long-term hormone therapy option, it is optimal to find an estrogen therapy regimen that is selective to its target tissue. Recently, phytoestrogens have been found to exert selective, beneficial effects on cognition and brain. For example, genistein and diadzein produce neuroprotective effects in cognitive brain regions (Zhao, Chen, & Diaz Brinton, 2002). The purpose of this study was threefold: 1) to examine the cognitive impact of phytoestrogens in young ovariectomized rats, 2) to replicate the dose effects found in the Luine study (Luine et al., 2006), while controlling for manufacturer differences, and 3) to assess if the rodent diet used in our laboratory has an estrogenic-like cognitive impact.The current findings suggest that, at least for object memory, diets containing varying amounts of phytoestrogens can alter cognition, with diets containing high amounts of phytoestrogens showing potential benefits to this type of memory.
ContributorsWhitton, Elizabeth Nicole (Author) / Bimonte-Nelson, Heather (Thesis director) / Presson, Clark (Committee member) / Baxter, Leslie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2013-05
Description
Substance abuse disorders affect 15.3 million people worldwide. The field has primarily focused on dopaminergic drugs as treatments for substance use disorders. However, recent work has demonstrated the potential of serotonergic compounds to treat substance abuse. Specifically, the serotonin 1B receptor (5-HT1BR), a Gi-coupled receptor located throughout the mesocorticolimbic dopamine system, has been implicated in the incentive motivational and rewarding effects of cocaine. Our research suggests that the stimulation of 5-HT1BRs produces different effects at various time points in the addiction cycle. During maintenance of chronic cocaine administration, 5-HT1BR stimulation has a facilitative effect on the reinforcing properties of cocaine. However 5-HT1BR stimulation exhibits inhibitory effects on reinforcement during prolonged abstinence from cocaine. The aim of this study was to examine the possibility of a switch in the functional role of 5-HT1BRs in the locomotor effects of cocaine at different time points of chronic cocaine administration in mice. We found that the 5-HT1BR agonist CP 94,253 increased locomotor activity in mice tested one day after the last chronic cocaine administration session regardless of whether the chronic treatment was cocaine or saline and regardless of challenge injection (i.e., cocaine or saline). Yet after abstinence, CP 94,253 induced a decrease in locomotor activity in mice challenged with saline and attenuated cocaine-induced locomotion relative to cocaine challenge after vehicle pretreatment. These findings suggest that a switch in the functional role of 5-HT1BR is observed at different stages of the addiction cycle and further suggest that clinical applications of drugs acting on 5-HT1BR should consider these effects.
ContributorsBrunwasser, Samuel Joshua (Author) / Neisewander, Janet (Thesis director) / Pentkowski, Nathan (Committee member) / Der-Ghazarian, Taleen (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / Department of Psychology (Contributor)
Created2014-05
Description
The attainment of a meaningful existence is a one of the most fundamental human desires. While the pursuit for a meaningful existence is universal, the path to achieving it looks different for all people. An important aspect in achieving a meaningful existence is personal enlightenment that is attained through not only a profound understanding of one's own identity through reflection but also an awareness of the environment that has shaped that identity. The purpose of reflection should not be to attach blame or find excuses for the aspects of one's life that are unfavorable or shameful; rather, it should be to achieve the sense of inner peace that is integral in making informed and rational progress towards realizing aspects of an individual's life that bring meaning and happiness. The purpose of the following two sections is to demonstrate how an understanding of group-specific challenges regarding identity and upbringing may help those that identify with Chinese American or immigrant culture in their pursuit of a meaningful and satisfying existence. The first section provides a profile on some of the common issues facing Asian Americans, particularly how an immigrant approach to parenting can affect the degree of acculturation, mental health, and identity of immigrant children. The second section provides a personal backdrop to some of the themes discussed in the first section through an autoethnographic account from a Chinese American student. The purpose of the autoethnographic account is to demonstrate that leisure activities, such as music, can address issues regarding acculturation and identity that Asian Americans commonly face.
ContributorsWen, Charles H (Author) / Mantie, Roger (Thesis director) / Libman, Jeff (Committee member) / Department of Supply Chain Management (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This paper explores whether American football player Colin Kaepernick and other athletes’ refusal in 2016 to acknowledge the national anthem symbolizes a form of nationalism in the United States. At first glance, the rising support of “un-American” acts that reject traditional patriotism would imply that American nationalism is faltering. If one observes the colloquial understanding of nationalism as extreme commitment to a country, this may be true. But after closer examination, the pattern instead depicts a polarization of two distinct forms of nationalism — ethnocentric nationalism and what I call multicultural nationalism, both intensifying away from each other.
As opposed to colloquial understanding, there is no standard scholarly definition of nationalism, but it is widely seen as zeal over an identity that strives to manifest into an organized state. Despite this minimal consensus, nationalism is usually equated with an ethnocentric conception of the nation-state, what I recognize to be ethnocentric nationalism, the commitment to a linguistically, racially, and culturally likeminded nation. I argue that this traditional, ethnocentric understanding of nationalism is only one interpretation of nationalism. Ethnocentric nationalism has and continues to be in tension with a more recently established interpretation of the nation, which I call multicultural nationalism: the commitment to a country’s principles rather than to its racial, cultural, and religious ties.
A common acceptance of difference is growing in the United States as shown by Kaepernick’s public support in the face of patriotic conformity. This perspective draws from the United States’ ideological roots that argue for one nation made up of many, e pluribus unum, so that foreign backgrounds should not just be accepted but also embraced to form a more diverse nation. The passion for a progressive, multicultural America can be translated into its own movement of multicultural nationalism. In this context, the support for Kaepernick’s actions no longer appears to represent increased dissent from the United States, but instead seems to be an attempt to challenge ethnocentric nationalism’s claim to the nation.
This paper will begin by contrasting the reactions to Kaepernick’s protest and to protests before him in order to contend that nationalism is no longer characterized by only ethnocentric tradition. I will analyze theoretical studies on nationalism to dispute this common understanding that nationalism is solely ethnocentric. I will argue that nationalism, rather, is the intense manifestation of a community’s identity within a political state; the identity of which can be either ethnocentric or multicultural. The Kaepernick ordeal will be used to signify the greater division in the American public over whether a multicultural or ethnocentric conception of the nation should be supported in the United States. Lastly, this paper will observe how the Kaepernick protest suggests multicultural nationalism’s viability in today’s politically progressive environment, and how multiculturalism should embrace nationalism to advance its platform.
As opposed to colloquial understanding, there is no standard scholarly definition of nationalism, but it is widely seen as zeal over an identity that strives to manifest into an organized state. Despite this minimal consensus, nationalism is usually equated with an ethnocentric conception of the nation-state, what I recognize to be ethnocentric nationalism, the commitment to a linguistically, racially, and culturally likeminded nation. I argue that this traditional, ethnocentric understanding of nationalism is only one interpretation of nationalism. Ethnocentric nationalism has and continues to be in tension with a more recently established interpretation of the nation, which I call multicultural nationalism: the commitment to a country’s principles rather than to its racial, cultural, and religious ties.
A common acceptance of difference is growing in the United States as shown by Kaepernick’s public support in the face of patriotic conformity. This perspective draws from the United States’ ideological roots that argue for one nation made up of many, e pluribus unum, so that foreign backgrounds should not just be accepted but also embraced to form a more diverse nation. The passion for a progressive, multicultural America can be translated into its own movement of multicultural nationalism. In this context, the support for Kaepernick’s actions no longer appears to represent increased dissent from the United States, but instead seems to be an attempt to challenge ethnocentric nationalism’s claim to the nation.
This paper will begin by contrasting the reactions to Kaepernick’s protest and to protests before him in order to contend that nationalism is no longer characterized by only ethnocentric tradition. I will analyze theoretical studies on nationalism to dispute this common understanding that nationalism is solely ethnocentric. I will argue that nationalism, rather, is the intense manifestation of a community’s identity within a political state; the identity of which can be either ethnocentric or multicultural. The Kaepernick ordeal will be used to signify the greater division in the American public over whether a multicultural or ethnocentric conception of the nation should be supported in the United States. Lastly, this paper will observe how the Kaepernick protest suggests multicultural nationalism’s viability in today’s politically progressive environment, and how multiculturalism should embrace nationalism to advance its platform.
ContributorsFite, Owen Gunehame (Author) / Suk, Mina (Thesis director) / Voorhees, Matthew (Committee member) / School of Politics and Global Studies (Contributor, Contributor) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
"Filling a Body That's Yours" is a collection of poetry that celebrates queer survival and the fluidity and mutability of identity. The poems arise from personal experience and expand to the universal in order to question and critique constructs of mental illness, queerness, transness, and identity. Via intuitive imagistic shifts, unexpected language, and urgent vulnerability, the poems share a personal account of mental illness and treatment, and set out to critique the mental health industrial complex and shortcomings in language, psychiatry, and psychology. For this project, the collection of poems is coupled with a written analytical component that discusses the personal and theoretical backgrounds for the work, as well as poetics and influences. The essay specifically addresses three main themes that appear in the poems: queerness/gender, mental illness and treatment, and identity, using theorists such as Judith Butler and David Hume. Further, the essay provides personal background for the work and discusses poetic influences such as Sylvia Plath, Li-Young Lee, Claudia Rankine, and Norman Dubie. Both the poems and the essay, while addressing these themes, attempt to ask and examine questions such as: "Is my gender entirely mine? Was it thrust wholly or in part upon me? Do I choose to claim queerness, or is it innate?" In asking these questions, the poems challenge readers to consider how they came to understand their bodies as gendered, and what political ends their identities may serve. Ultimately, the poems and their theoretical counterparts complicate constructs we commonly accept as essential givens, and meditate upon timeless existential questions in new, visceral ways.
ContributorsWinter, Elliot (Author) / Fette, Donald (Thesis director) / Murdock, Natasha (Committee member) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Aberrant signaling through the canonical RAS/RAF/MEK/ERK (ERK/MAPK) pathway leads to the pathology of a group of neurodevelopmental disorders called RASopathies. RASopathies are caused by germline mutations in the ERK/MAPK pathway and have an incidence of approximately 1:2000 births. The majority of RASopathies stem from mutations that cause gain-of-function in the ERK/MAPK pathway. In this study, we have begun to unravel the roles that GABAergic interneurons play in the pathology of RASopathies. Our data demonstrate that gain-of-function ERK/MAPK signaling expressed in a GABAergic interneuron-specific fashion leads to forebrain hyperexcitability in mutant mice. Further, some GABAergic interneurons experience activated-caspase 3 mediated apoptosis in the embryonic subpallium, leading to a loss of PV-expressing interneurons in the somatosensory cortex. We found that pharmaceutical intervention during embryogenesis using a MEK1 inhibitor may be effective in preventing apoptosis of these neurons. Future work is still needed to understand the mechanism of the death of GABAergic interneurons and to further pursue therapeutic approaches. Taken together, this study suggests potential roles of cortical GABAergic interneurons in ERK/MAPK-linked pathologies and indicates possible approaches to provide therapy for these conditions.
ContributorsShah, Shiv (Author) / Newbern, Jason (Thesis director) / Gipson-Reichardt, Cassandra (Committee member) / School of Life Sciences (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
In epilepsy, malformations that cause seizures often require surgery. The purpose of this research is to join forces with the Multi-Center Epilepsy Lesion Detection (MELD) project at University College London (UCL) in order to improve the process of detecting lesions in patients with drug-resistant epilepsy. This, in turn, will improve surgical outcomes via more structured surgical planning. It is a global effort, with more than 20 sites across 5 continents. The targeted populations for this study include patients whose epilepsy stems from Focal Cortical Dysplasia. Focal Cortical Dysplasia is an abnormality of cortical development, and causes most of the drug-resistant epilepsy. Currently, the creators of MELD have developed a set of protocols which wrap various
commands designed to streamline post-processing of MRI images. Using this partnership, the Applied Neuroscience and Technology Lab at PCH has been able to complete production of a post-processing pipeline which integrates locally sourced smoothing techniques to help identify lesions in patients with evidence of Focal Cortical Dysplasia. The end result is a system in which a patient with epilepsy may experience more successful post-surgical results due to the
combination of a lesion detection mechanism and the radiologist using their trained eye in the presurgical stages. As one of the main points of this work is the global aspect of it, Barrett thesis funding was dedicated for a trip to London in order to network with other MELD project collaborators. This was a successful trip for the project as a whole in addition to this particular thesis. The ability to troubleshoot problems with one another in a room full of subject matter
experts allowed for a high level of discussion and learning. Future work includes implementing machine learning approaches which consider all morphometry parameters simultaneously.
commands designed to streamline post-processing of MRI images. Using this partnership, the Applied Neuroscience and Technology Lab at PCH has been able to complete production of a post-processing pipeline which integrates locally sourced smoothing techniques to help identify lesions in patients with evidence of Focal Cortical Dysplasia. The end result is a system in which a patient with epilepsy may experience more successful post-surgical results due to the
combination of a lesion detection mechanism and the radiologist using their trained eye in the presurgical stages. As one of the main points of this work is the global aspect of it, Barrett thesis funding was dedicated for a trip to London in order to network with other MELD project collaborators. This was a successful trip for the project as a whole in addition to this particular thesis. The ability to troubleshoot problems with one another in a room full of subject matter
experts allowed for a high level of discussion and learning. Future work includes implementing machine learning approaches which consider all morphometry parameters simultaneously.
ContributorsHumphreys, Zachary William (Author) / Kodibagkar, Vikram (Thesis director) / Foldes, Stephen (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Identity is shaped through the integration of one’s beliefs, experiences, relationships, choices, and other such phenomena, and the resulting identity created by an individual continues to feed back into this process by influencing future identity formation. In consideration of the numerous factors contributing to identity, this Honors Thesis accumulates an interdisciplinary understanding of identity by pulling from 17 research disciplines and uses this knowledge to inform a collection of poems centered on the theme of my own identity exploration. The Repko (2008) model for interdisciplinary research was loosely followed and using this framework highlighted the interconnectivity of literature research and, from a broader perspective, knowledge in general. A second framework was chosen to further encapsulate this knowledge and apply it to my own identity. Marcia’s Identity Status Theory is a fluid model by which I was able to understand the different identity statuses I was illustrating through poetry (Marcia, 1966; Marcia et. al., 1980). The poetry component of this project included completion of a poetry workshop and creation of a twenty-eight-poem chapbook. Together, the interdisciplinary research and identity model offer insight into the identity connections presented in this collection of poems. However, the frameworks used in this project are limited in that they do not completely capture the true essence of identity. While many disciplines’ contributions to identity research were considered in this Honors Thesis, identity is such a large concept that it is difficult to completely capture my own identity, let alone the identities of others. While others may find research articles or poems they relate to and may possibly learn about themselves from what is presented in this document, identity is unique to each individual and a proper compilation of identity research would need to be far more extensive than the reach of this Honors Thesis.
ContributorsKodet, Aryn Mikaela (Author) / deLusé, Stephanie (Thesis director) / Dickens, Andrea (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05