Barrett

Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

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Transfecting Genetically Encoded Fluorophores for the Identification of Neuronal Subtypes

Description

Advancing the understanding and treatment of many neurological disorders can be achieved by improving methods of neuronal detection at increased depth in the mammalian brain. Different cell subtypes cannot be detected using non-invasive techniques beyond 1 mm from cortical surface, in the context of targeting particular cell types in vivo…

Advancing the understanding and treatment of many neurological disorders can be achieved by improving methods of neuronal detection at increased depth in the mammalian brain. Different cell subtypes cannot be detected using non-invasive techniques beyond 1 mm from cortical surface, in the context of targeting particular cell types in vivo (Wang, 2012). These limitations in the depth of imaging and targeting are due to optical scattering (Ntziachristos, 2010). In order to overcome these restrictions, longer wavelength fluorescent proteins have been utilized by researchers to see tagged cells at depth. Optical techniques such as two-photon and confocal microscopy have been used in combination with fluorescent proteins to expand depth, but are still limited by the penetration depth of light due to optical scattering (Lee, 2015). This research aims to build on other detection methods, such as the photoacoustic effect and automated fluorescence-guided electrophysiology, to overcome this limitation.
ContributorsAridi, Christina (Author) / Smith, Barbara (Thesis director) / Marschall, Ethan (Committee member) / Barrett, The Honors College (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Harrington Bioengineering Program (Contributor)
Created2023-05
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Photoacoustic Imaging with Schlieren Optics to Provide Real-Time Imaging

Description
Breast cancer can be imaged at greater depths using photoacoustic imaging to differentiate between cancerous and non-cancerous tissue. Current photoacoustic modalities struggle to display images in real-time because of the required image reconstruction. In this work, we aim to create a real-time photoacoustic imaging system where the photoacoustic effect is…

Breast cancer can be imaged at greater depths using photoacoustic imaging to differentiate between cancerous and non-cancerous tissue. Current photoacoustic modalities struggle to display images in real-time because of the required image reconstruction. In this work, we aim to create a real-time photoacoustic imaging system where the photoacoustic effect is detected through changes in index of refraction. To reach this aim, two methods are applied to visualize the acoustic waves including Schlieren optics and differential interference contrast microscopy. This combined approach provides a new tool for the widespread application in clinical settings.
ContributorsSmetanick, Derek (Author) / Burgett, Joshua (Co-author) / Smith, Barbara (Thesis director) / Muthuswamy, Jitendran (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor) / School of Life Sciences (Contributor)
Created2022-05