Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Displaying 1 - 4 of 4
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- All Subjects: Memory
- Creators: School of Molecular Sciences
Description
Drospirenone (DRSP) is a novel, pharmacologically unique synthetic progestin with properties more similar to the endogenous progestogen, progesterone, than any other progestin currently on the market. While a significant amount of research has been conducted on the risks associated with DRSP, the impact of DRSP on cognition, especially in reference to learning and memory, is not well understood. However, it is imperative to fully understand the cognitive effects of DRSP, both alone and in combination with EE (as taken in a combined oral contraceptive [COC]), so that women and their physicians can make a fully-informed decision when deciding to take a DRSP-containing COC. Study 1 examined the effects of three doses of DRSP in order to determine the optimal dose for combining with EE, and found that the medium dose of DRSP (30 µg/day) enhanced spatial working memory performance. In Study 2, the medium dose of DRSP from Study 1 was combined with low (0.125 µg/day) and high (0.3 µg/day) doses of EE to examine the effects of DRSP as taken with EE in a COC. The results from Study 2 indicated that when DRSP was combined with a low, but not high, dose of EE, spatial working memory impairments were seen at the highest working memory load. Anxiety-like behavior was evaluated using the OFT, and DRSP was shown to decrease measures of anxiety-like behavior. Additionally, while treatment with a high dose of EE decreased several measures of anxiety-like behavior, a low dose of EE did not, suggestive of a dose response. Taken together, the findings presented from both studies suggest that some of the cognitive effects of the combination of DRSP with EE are different than those of either hormone administered on its own. Further exploration in a preclinical, ovary-intact animal model is a next step to fully understand these effects in the translational context of a contraceptive, given that women taking an EE-DRSP combination are typically ovary-intact.
ContributorsPoisson, Mallori Louise (Author) / Bimonte-Nelson, Heather (Thesis director) / Doane, Leah (Committee member) / School of Nutrition and Health Promotion (Contributor) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The mammalian target of rapamycin (mTOR) is integral in regulating cell growth as it maintains a homeostatic balance of proteins by modulating their synthesis and degradation. In the brain, mTOR regulates protein-driven neuroplastic changes that modulate learning and memory. Nevertheless, upregulation of mTOR can cause detrimental effect in spatial memory and synaptic plasticity. The proline-rich Akt-substrate 40 kDa (PRAS40) is a key negative regulator of mTOR, as it binds mTOR and directly reduces its activity. To investigate the role of PRAS40 on learning and memory, we generated a transgenic mouse model in which we used the tetracycline-off system to regulate the expression of PRAS40 specifically in neurons of the hippocampus. After induction, we found that mice overexpressing PRAS40 performed better than control mice in the Morris Water Maze behavioral test. We further show that the improvement in memory was associated with a decrease in mTOR signaling, an increase in dendritic spines in hippocampal pyramidal neurons, and an increase in the levels of brain-derived neurotrophic factor (BDNF), a neurotrophin necessary for learning and memory. This is the first evidence that shows that increasing PRAS40 in the mouse brain enhances learning and memory deficits.
ContributorsSarette, Patrick William (Author) / Oddo, Salvatore (Thesis director) / Caccamo, Antonella (Committee member) / Kelleher, Raymond (Committee member) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The need to fully understand the possible consequences of young-adult cannabis use has become increasingly critical as a result of major cannabis policy changes. The purpose of this study was to determine if young-adult users exhibit cognitive deficits on laboratory-based tests and memory and attention deficits in everyday life. Participants were 152 students from a large U.S. university enrolled in introductory psychology courses and the top and bottom 10% of the 12-item Yale University PRIME Screening Test for psychotic-like experiences. Participants were asked about their cannabis use and were given six cognitive tests spanning executive function and memory. To test functional impairment in memory and attention, participants were asked to nominate informants (people who knew them well) and these rated the participants on an attention problems scale of four items and a memory problems scale of three items. Results showed that individuals who used cannabis more frequently were rated as having more attention and memory problems and that, consistent with prior research, more frequent cannabis use was associated with worse memory test performance, though the association was not present between frequency of use and executive function test performance. Additionally, it was found that informant-reported attention problems were associated with poorer performance on two of the executive function cognitive tests. The present findings suggest that individuals who use cannabis more frequently experience noticeable memory and attention problems in everyday life, despite the lack of significant correlation between this functional impairment and cognitive test performance. Informant reports, therefore, may be useful in future research for understanding or predicting cognitive impairment in young adults.
ContributorsCarbajal, Lucia (Author) / Meier, Madeline (Thesis director) / McClure, Samuel (Committee member) / Department of Psychology (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Familiar Places: Ghosts of a Memory is a thesis exhibition, presented in Gallery 100 in Tempe, AZ, accompanied by a written investigation into the function of photography in the home and art. This project is a diaristic photographic record including images of myself, my family, my environment, and mementos or objects that embody family history. I am interested in what we hold onto to keep memories and create our "home". I moved frequently growing up so my sense of home became firmly grounded in family, tradition, and the things we kept close, making home a practiced space not a place. This thesis project explores how material culture, including photographs, is used in creating the space of the home. Questions regarding the nature of the photograph as a memory keeping device or memory trigger is investigated to understand their usefulness and accuracy to the memory. A deeper examination of the difference between an artist's photograph of family and home versus the family photograph is discussed and presented by utilizing installations in the exhibition. The photographs can be seen at www.gwendolynanne.com
ContributorsDavies, Gwendolyn Anne (Author) / Smith, Stephen Mark (Thesis director) / Danh, Binh (Committee member) / Loebenberg, Abby (Committee member) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12