Barrett

Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

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Together but not for better? Conjugated equine estrogens, estradiol, androstenedione, and their interactions on spatial memory in C-57 mice

Description
Menopause is associated with a wide array of negative symptoms. As average lifespan increases due to advances in healthcare and technology, more women are spending a larger portion of their lives in a menopausal state low in estrogen and progesterone. Hormone therapies such as Conjugated Equine Estrogens (CEE) and the…

Menopause is associated with a wide array of negative symptoms. As average lifespan increases due to advances in healthcare and technology, more women are spending a larger portion of their lives in a menopausal state low in estrogen and progesterone. Hormone therapies such as Conjugated Equine Estrogens (CEE) and the bioidentical estrogen, 17-estradiol (E2), are commonly prescribed to treat the negative symptoms of menopause. Our laboratory has previously shown that CEE has differential effects on cognitive ability depending on whether menopause is transitional (VCD) or surgical (ovariectomy, OVX). Further, the negative impact of CEE on cognitive function in a transitional ovary-intact model of menopause was associated with high levels of serum androstenedione; the primary hormone circulating in a follicle-deplete menopausal state. Here, we investigate the cognitive effects of these two common hormone therapies separately, and in conjunction with the hormone androstenedione, in a "blank-slate" OVX mouse model. We assessed cognitive ability using two behavioral tasks such at the Water Radial Arm Maze (WRAM, measuring spatial working and reference memory) and the Morris water maze (MM, measuring spatial reference memory). In the WRAM, every treatment group saw impaired performance compared to Vehicle but the combination group of E2 plus Androstenedione. In the MM, the combination group of E2 plus Androstenedione actually enhanced performance in the maze compared to every other comparable group. Translationally, these results suggest that CEE given in the presence of an androstenedione-dominant hormone milieu is impairing to cognition, E2 in this same manner is not. These results yield valuable insight into optimal hormone therapies for menopausal women.
ContributorsGranger, Steven Jay (Author) / Bimonte-Nelson, Heather (Thesis director) / Presson, Clark (Committee member) / Hiroi, Sheri (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Familiar Places: Ghosts of a Memory

Description
Familiar Places: Ghosts of a Memory is a thesis exhibition, presented in Gallery 100 in Tempe, AZ, accompanied by a written investigation into the function of photography in the home and art. This project is a diaristic photographic record including images of myself, my family, my environment, and mementos or…

Familiar Places: Ghosts of a Memory is a thesis exhibition, presented in Gallery 100 in Tempe, AZ, accompanied by a written investigation into the function of photography in the home and art. This project is a diaristic photographic record including images of myself, my family, my environment, and mementos or objects that embody family history. I am interested in what we hold onto to keep memories and create our "home". I moved frequently growing up so my sense of home became firmly grounded in family, tradition, and the things we kept close, making home a practiced space not a place. This thesis project explores how material culture, including photographs, is used in creating the space of the home. Questions regarding the nature of the photograph as a memory keeping device or memory trigger is investigated to understand their usefulness and accuracy to the memory. A deeper examination of the difference between an artist's photograph of family and home versus the family photograph is discussed and presented by utilizing installations in the exhibition. The photographs can be seen at www.gwendolynanne.com
ContributorsDavies, Gwendolyn Anne (Author) / Smith, Stephen Mark (Thesis director) / Danh, Binh (Committee member) / Loebenberg, Abby (Committee member) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12