Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- All Subjects: Social Media
- All Subjects: Alzheimer's Disease
Advances in cellular reprogramming, have enabled the generation of in vitro disease models that can be used to dissect disease mechanisms and evaluate potential therapeutics. To that end, efforts by many groups, including the Brafman laboratory, to generated patient-specific hiPSCs have demonstrated the promise of studying AD in a simplified and accessible system. However, neurons generated from these hiPSCs have shown some, but not all, of the early molecular and cellular hallmarks associated with the disease. Additionally, phenotypes and pathological hallmarks associated with later stages of the human disease have not been observed with current hiPSC-based systems. Further, disease relevant phenotypes in neurons generated from SAD hiPSCs have been highly variable or largely absent. Finally, the reprogramming process erases phenotypes associated with cellular aging and, as a result, iPSC-derived neurons more closely resemble fetal brain rather than adult brain.
It is well-established that in vivo cells reside within a complex 3-D microenvironment that plays a significant role in regulating cell behavior. Signaling and other cellular functions, such as gene expression and differentiation potential, differ in 3-D cultures compared with 2-D substrates. Nonetheless, previous studies using AD hiPSCs have relied on 2-D neuronal culture models that do not reflect the 3-D complexity of native brain tissue, and therefore, are unable to replicate all aspects of AD pathogenesis. Further, the reprogramming process erases cellular aging phenotypes. To address these limitations, this project aimed to develop bioengineering methods for the generation of 3-D organoid-based cultures that mimic in vivo cortical tissue, and to generate an inducible gene repression system to recapitulate cellular aging hallmarks.
My thesis project took the form of a networking blog for adoptable animals at the local pound. I created unique photos of the dogs and wrote up bios for them so that they became more accessible to people who could not physically visit the shelter very often. I brought the dogs to life by sharing a part of their story and encouraging people to care about what happened to them. This issue is especially close to my heart because I have loved animals all my life and started fostering dogs a few years ago.
The project was a huge success. I profiled 37 dogs and they amassed hundreds of thousands of views both on my Wordpress site and on the project Facebook page. Five of my dogs were euthanized, about a 13% euthanasia rate. Compared to the owner surrender euthanasia rate of previous years, this rate is remarkably low. In 2012, about 43.86% of owner surrenders were euthanized. In 2013, about 39.19% of owner surrenders were euthanized. In 2014, about 33.27% of owner surrenders were euthanized. My euthanasia rate was essentially less than half of the last year’s owner surrender euthanasia rate.
I think I absolutely proved my point. The power of networking in unique ways and leveraging the influence of social media cannot be underestimated. Less dogs were killed because of my project. If that’s not success, then I don’t know what is.