Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- All Subjects: Immigration
- All Subjects: Neuroscience
Description
I wrote creative non-fiction to enrich and expand the existing narratives of Mexican immigrant experiences by preserving oral histories and thus, influence a broader cultural understanding. As a first-generation Mexican-American writer, I believe there is a pressing need to explore the stories of my people, particularly those of my father. I also acknowledge the master narratives that work to influence and consequently oppress my own voice as a writer. The master narrative values white experiences and voices in narrative writing while devaluing work from non-white authors. Thus, it became critical for me to reclaim my true voice as a writer and consequently, disrupt this harmful master narrative. Through this project, I reclaimed my voice as a writer, the one that pays homage to my cultural roots by writing my father's stories authentically. I integrated my heritage language Spanish and English in the writing of these stories. As the daughter of immigrants, this is an important way of representing my identity through my writing. Additionally, the importance of this work is greatly exemplified by the unity that springs forth among Mexican immigrants and children of those immigrants when experiences like these are shared and released into the world. At present, the Mexican immigrant community faces social and political discrimination in the form of misrepresentation, anti-immigrant rhetoric, and racism. Therefore, there is a palpable need for more accurate representation to combat these issues. Written storytelling provides a valuable glimpse into my father's experience as a Mexican immigrant and is a valuable tool to challenge harmful master narratives.
ContributorsVillezcas, Araceli (Author) / de la Garza, Amira (Thesis director) / Cuadraz, Gloria (Committee member) / School of Sustainability (Contributor) / Hugh Downs School of Human Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Prior expectations can bias evaluative judgments of sensory information. We show that information about a performer's status can bias the evaluation of musical stimuli, reflected by differential activity of the ventromedial prefrontal cortex (vmPFC). Moreover, we demonstrate that decreased susceptibility to this confirmation bias is (a) accompanied by the recruitment of and (b) correlated with the white-matter structure of the executive control network, particularly related to the dorsolateral prefrontal cortex (dlPFC). By using long-duration musical stimuli, we were able to track the initial biasing, subsequent perception, and ultimate evaluation of the stimuli, examining the full evolution of these biases over time. Our findings confirm the persistence of confirmation bias effects even when ample opportunity exists to gather information about true stimulus quality, and underline the importance of executive control in reducing bias.
ContributorsAydogan, Goekhan (Co-author, Committee member) / Flaig, Nicole (Co-author) / Larg, Edward W. (Co-author) / Margulis, Elizabeth Hellmuth (Co-author) / McClure, Samuel (Co-author, Thesis director) / Nagishetty Ravi, Srekar Krishna (Co-author) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Egr3 is an immediate early gene transcription factor that shows genetic association with schizophrenia, and is found in decreased levels in the brains of schizophrenia patients. Schizophrenia patients also exhibit cognitive and memory deficits, both of which Egr3 has been shown to play a crucial role in. Additionally, high levels of DNA damage are found in the brains of schizophrenia patients. A recent study has shown that DNA damage occurs as a result of normal physiological activity in neurons and is required for induction of gene expression of a subset of early response genes. Also, failure to repair this damage can lead to gene expression in a constitutive switched on state. Egr3 knockout (Egr3-/-) mice show deficits in hippocampal synaptic plasticity and memory. We were interested in characterizing downstream targets of EGR3 in the hippocampus. To determine these targets, electroconvulsive seizure (ECS) was carried out in Egr3 -/- versus wild type (WT) mice, and a microarray study was first done in our lab. ECS maximally stimulates Egr3 expression and we hypothesized that there would be gene targets that are differentially expressed between Egr3 -/- and WT mice that had been subjected to ECS. Two separate analyses of the microarray yielded 65 common genes that were determined as being differentially expressed between WT and Egr3 -/- mice after ECS. Further Ingenuity Pathway Analysis of these 65 genes indicated the Gadd45 signaling pathway to be the top canonical pathway, with the top four pathways all being associated with DNA damage or DNA repair. A literature survey was conducted for these 65 genes and their associated pathways, and 12 of the 65 genes were found to be involved in DNA damage response and/or DNA repair. Validation of differential expression was then conducted for each of the 12 genes, in both the original male cohort used for microarray studies and an additional female cohort of mice. 7 of these genes validated through quantitative real time PCR (qRT-PCR) in the original male cohort used for the microarray study, and 4 validated in both the original male cohort and an independent female cohort. Bioinformatics analysis yielded predicted EGR3 binding sites in promoters of these 12 genes, validating their role as potential transcription targets of EGR3. These data reveal EGR3 to be a novel regulator of DNA repair. Further studies will be needed to characterize the role of Egr3 in repairing DNA damage.
ContributorsBarkatullah, Arhem Fatima (Author) / Newbern, Jason (Thesis director) / Gallitano, Amelia (Committee member) / Marballi, Ketan (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The goal of my study is to test the overarching hypothesis that art therapy is effective because it targets emotional dysregulation that often accompanies significant health stressors. By reducing the salience of illness-related stressors, art therapy may improve overall mood and recovery, particularly in patients with cancer. After consulting the primary literature and review papers to develop psychological and neural mechanisms at work in art therapy, I created a hypothetical experimental procedure to test these hypotheses to explain why art therapy is helpful to patients with chronic illness. Studies found that art therapy stimulates activity of multiple brain regions involved in memory retrieval and the arousal of emotions. I hypothesize that patients with chronic illness have a reduced capacity for emotion regulation, or difficulty recognizing, expressing or altering illness-related emotions (Gross & Barrett, 2011). Further I hypothesize that art therapy improves mood and therapeutic outcomes by acting on the emotion-processing regions of the limbic system, and thereby facilitating the healthy expression of emotion, emotional processing, and reappraisal. More mechanistically, I propose art therapy reduces the perception or salience of stressors by reducing amygdala activity leading to decreased activation of the hypothalamic-pituitary-adrenal (HPA) axis. The art therapy literature and my hypothesis about its mechanisms of action became the basis of my proposed study. To assess the effectiveness of art therapy in alleviating symptoms of chronic disease, I am specifically targeting patients with cancer who exhibit a lack of emotional regulation. Saliva is collected 3 times a week on the day of intervention: morning after waking, afternoon, and evening. Stress levels are tested using one-hour art therapy sessions over the course of 3 months. The Perceived Stress Scale (PSS) assesses an individual's perceived stress and feelings in past and present situations, for the control and intervention group. To measure improvement in overall mood, 10 one-hour art sessions are performed on patients over 10 weeks. A one-hour discussion analyzing the participants' artwork follows each art session. The Spielberger State-Trait Anxiety Inventory (STAI) assesses overall mood for the intervention and control groups. I created rationale and predictions based on the intended results of each experiment.
ContributorsAluri, Bineetha C. (Author) / Orchinik, Miles (Thesis director) / Davis, Mary (Committee member) / Essary, Alison (Committee member) / School of Life Sciences (Contributor) / School for the Science of Health Care Delivery (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Immigration policy in the United States today is complex and far-encompassing. This project aims to present it in an easily accessible way: Through the eyes of those who have experienced its effects in a deeply personal manner. This online project, housed at http://immigrant-experience.com/, includes profiles of four people who have immigrated to the United States from other countries. The website includes graphics and multimedia elements, that help to tell their stories. It also provides information about immigration statistics, research and policy. The DREAMer who came to the country as a child, the young Mexican man on a seasonal visa, and the Eritrean refugee share in the immigrant experience, but the effects of U.S. policy on their lives are vastly different. Factors at play include age, education, country of origin and socioeconomic status. These factors are what shape the policy that dictates whether an immigrant can become an American citizen. They are also what make Gloria, Adrian and Azarya's stories so unique. It is a multitude of personal stories that collectively define the immigrant experience. These stories may be drastically different, depending on the country of origin and circumstances of each individual, but some aspects of the experience are shared. The difficulties inherent in uprooting oneself from a familiar community are common to "immigrants" of all shapes and sizes: students moving out of state for college, new hires moving to a new city, parents moving their children into a better neighborhood, etc. Through in-depth profiles of immigrants from a wide variety of backgrounds, this project highlights those shared experiences while showing the diversity of personal stories, challenging contemporary stereotypes about immigrant populations.
ContributorsMiller, Faith Anne (Author) / Rodriguez, Rick (Thesis director) / Manning, Jason (Committee member) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / School of International Letters and Cultures (Contributor) / Department of English (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Architecture has an ability to shape us and focus on forms and efficiency yet frequently ignores relationships between the form and cognition. This negligence creates lost opportunities for creating a link between action and perception, embodiment and aesthetics, imagination and empathy. Architecture is frequently not empathetic, lacking meaning to far too many people. Considering the application of neuroscience in architecture to nurture psychological and physiological response to architecture may be key to fostering healthy and positive relationships with space. Another connection that comes up in neuro-scientific research is how creativity plays into design and the understanding of design. Often, creativity is accompanied by metaphor, and neuroscientist Ramachandran is particularly interested in this. A curious phenomenon he has focused on is synaesthesia, Synaesthesia is a Greek-based word, syn meaning joined and aisthesis meaning sensation. It occurs when "Stimulation of one sensory modality automatically triggers perception in a second modality in the absence of any direct stimulation to this modality." Further, the study and application of synaesthetic properties can help achieve this goal. Through the application of neuro-scientific research directed towards architecture, "Neuroarchitecture" is a possible tool that can create architecture that invokes positive responses in occupants. Through the consideration of building elements, natural forces, equal understanding, and synaesthesia, "neuroarchitecture" can be successful. Thus, with the consideration of neuroscience and synaesthesia there is a possibility of understanding what creates the certain emotions that one experiences in a space, and why people like certain places more than others. In a lecture covering this topic at Arizona State University's Design School, designer Ellen Lupton showed graphic visualizations of musical synaesthesia. Bird calls were translated into exceptionally fluid ribbons of moving color that ebbed and crashed with the rise and fall of the bird call. If these experiences can be expressed through digital art, then there may be a way to express them through architecture. The project takes focus on the architecture of flux, limbo, and threshold, within the specific context of the airport. The airport is a one of a kind architecture. There is little to no other architecture that serves as a threshold from one city, state, and country to another, that is full of people from all parts of the world, and is a space of limbo. In the flux of the airport, the individual feels a multitude of emotions, joys, sadness, frustration, and stresses. Studying circulation, movement of both the inhabitant and the architecture of the airport, the project will rigorously question if architecture can be scientifically formulated to create mental effects or if they are a result of atmospheric qualities.
ContributorsPniak, Nikola (Author) / Rocchi, Elena (Thesis director) / Taylor, Christopher (Committee member) / Hejduk, Renata (Committee member) / The Design School (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The purpose of this study is to document and analyze three women's English language learning journeys after moving from various parts of Mexico to Phoenix, Arizona. The study explores the effects of English as a Second Language (ESL) education on the social and cultural development of Mexican women students at Friendly House, whose mission is to "Empower Arizona communities through education and human services". The literature review section explores such topics as the complications and history of Mexican immigration to Phoenix and of state-funded ESL education in Phoenix. The consequent research study will entail a pair of interviews with the three beginner ESL students about their lives in Mexico compared to their lives in Phoenix, with a specific focus on aspects of their language acquisition and cultural adjustment to life in Arizona. Photos of and by the consultants add to their stories and lead to a discussion about the implications of their experiences for ESL teachers. By documenting the consultants' experiences, this study finds many gaps in ESL education in Phoenix. Suggestions about how ESL programs and teaching methods can be modified to fit student's needs form the basis for the conclusions.
ContributorsDriscoll, Ashley Marisa (Author) / Horan, Elizabeth (Thesis director) / O'Connor, Brendan (Committee member) / Department of English (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The mammalian target of rapamycin (mTOR) is integral in regulating cell growth as it maintains a homeostatic balance of proteins by modulating their synthesis and degradation. In the brain, mTOR regulates protein-driven neuroplastic changes that modulate learning and memory. Nevertheless, upregulation of mTOR can cause detrimental effect in spatial memory and synaptic plasticity. The proline-rich Akt-substrate 40 kDa (PRAS40) is a key negative regulator of mTOR, as it binds mTOR and directly reduces its activity. To investigate the role of PRAS40 on learning and memory, we generated a transgenic mouse model in which we used the tetracycline-off system to regulate the expression of PRAS40 specifically in neurons of the hippocampus. After induction, we found that mice overexpressing PRAS40 performed better than control mice in the Morris Water Maze behavioral test. We further show that the improvement in memory was associated with a decrease in mTOR signaling, an increase in dendritic spines in hippocampal pyramidal neurons, and an increase in the levels of brain-derived neurotrophic factor (BDNF), a neurotrophin necessary for learning and memory. This is the first evidence that shows that increasing PRAS40 in the mouse brain enhances learning and memory deficits.
ContributorsSarette, Patrick William (Author) / Oddo, Salvatore (Thesis director) / Caccamo, Antonella (Committee member) / Kelleher, Raymond (Committee member) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Zoraida Ladrón de Guevarra was born in 1936 in Coyula, Mexico, a small village in the state of Oaxaca. Her father’s passing required Zoraida to find a job at age fourteen to support her family. Her story, a 200-page memoir entitled “After Papa Died,” follows Zoraida’s time as a servant and eventual nanny in Veracruz. Flashing back to memories of her hometown and the people living in it, the story ends before she enters America first as a visitor in 1954, and later on a working Visa in 1957—the first woman in her village to leave to the United States. Hers is a story relevant today, evident with the paradoxes explored between poverty and riches, patriarchy and matriarchy, freedom and captivity. Assimilation impacts the reading of this memoir, as Zoraida began writing the memoir in her 80s (around fifty years after gaining American citizenship). This detailed family history is about the nature of memory, community, and in particular, the experience of being an immigrant. This thesis project centers on this text and includes three components: an edited memoir, informational interviews, and an introduction. Beginning as a diary steeped in the tradition of oral history, the memoir required a “translation” into a written form; chapters and chronological continuity helped with organization. Topics of interest from the story, such as identity, domestic violence, and religion, are further explored in a series of interviews with Zoraida. The inclusion of an introduction to the text contextualizes the stories documented in the memoir with supplemental information. The contents of the project are housed on a website: alongwaybabyproject.net.
ContributorsVan Slyke, Shea Elizabeth (Author) / Meloy, Elizabeth (Thesis director) / O'Flaherty, Katherine (Committee member) / Department of Supply Chain Management (Contributor) / Department of English (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The goal of this thesis project is to provide insight into the lives of Syrian refugees, asylum seekers, and migrants who have left Syria for the United States within the last 6 years, after the start of the conflict there. I have interviewed individuals who come from different regions of Syria, are members of different religious groups, and who have different opinions in regard to the conflict in Syria. One of the questions that I was most curious to ask and have answered was why America was selected as the final destination for their immigration. Along with their backstories from their time in Syria up until their arrival in the United States, I did research into the immigrants' acclimation process, and whether they feel that private organizations or that our government have helped them in that regard. I also collected data to see what the average amount of time to find a job and become self-sufficient in the United States is for these persons and their families. Although most educated Syrians know French, English, and Arabic, I was proven right in my hypothesis that many refugees have come to the United States knowing little, if any, English. Research was done into the programs that are offered to these people and their personal efforts to learn English were also documented. The primary purpose of this thesis was to find the economic and social effects of Syrian immigrants in the state of Arizona, and hopefully, on a larger scale. It was very challenging to get exact numbers on the amount of refugees and impossible to get specific details in regard to their economic impact on the economy. In order to get an approximation, I read David Card's research into the Mariel Boatlift, which documented the economic effects of Cuban immigrants on the Miami labor market, and Semih Tumen's work, titled, "The Economic Impact of Syrian Refugees on Host Countries: Quasi-Experimental Evidence from Turkey" which provides research-based analysis of the specific effects of Syrian refugees on the economy of Turkey. Conclusions for both the economic and social impact of Syrian refugees in the state of Arizona were made. Due to the current low numbers of Syrian refugees living in Arizona and the mentality that many of them possess, there is a net neutral economic impact. In regard to social impact, I was surprised to learn that the acclimation process for Syrian immigrants is relatively rapid, particularly when compared to other immigrant and refugee populations.
ContributorsGhazoul, John Anthony (Author) / Goegan, Brian (Thesis director) / Bonfiglio, Thomas (Committee member) / Department of Finance (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05