Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
Filtering by
The main character, Princess Alexandria, must navigate a world where the all magic is controlled by a power-hungry ruler, King Mordred. After he decides to pursue the Ruins of Kronos in order to gain control over time itself, the princess decides to intervene. Alexandria escapes the palace with her childhood best friend James, to stop him, nearly dying in the process, and finds a group of fairies who have lost their wings. The fairies help her discover the true origins and capabilities of magic, making her realize that she must restore it to the realm in order to stop King Mordred. Alexandria disguises herself as a man and joins the King’s Knights, befriending a rebel in disguise named Keith along the way, as she discovers her brother Noah may be on the King’s side. Together, they work to liberate lands oppressed by King Mordred’s rule, and by the Black Plague that Morgana has set upon them, all while uncovering the corruption present in their society.
A high density 3D tumor model was utilized to recapitulate the tumor microenvironment of ductal carcinoma in vitro. The tumor model consisted of MDA-MB-231 tumors seeded within micromolded collagen wells, chemically immobilized upon a surface treated PDMS substrate. CAFs were seeded within the greater collagen structure from which the microwells were formed. The combinatorial effect of anti-fibrotic drug (Tranilast) and chemotherapy drug (Doxorubicin) were studied within 3D co culture conditions. Specifically, the combinatorial effects of the drugs on tumor cell viability, proliferation, and invasion were examined dynamically upon coculture with CAFs using the microengineered model.
The results of the study showed that the combinatorial effects of Tranilast and Doxorubicin significantly decreased the proliferative ability of tumor cells, in addition to significantly decreasing the ability of tumor cells to remain viable and invade their surrounding stroma, compared to control conditions.