Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- All Subjects: Supply Chain Management
- All Subjects: Diabetes
Description
Brown adipose tissue (BAT) is thought to be important in combating obesity as it can expend energy in the form of heat, e.g. thermogenesis. The goal of this study was to study the effect of injected norepinephrine (NE) on the activation of BAT in rats that were fed a high fat diet (HFD). A dose of 0.25 mg/kg NE was used to elicit a temperature response that was measured using transponders inserted subcutaneously over the BAT and lower back and intraperitoneally to measure the core temperature. The results found that the thermic effect of the BAT increased after the transition from low fat diet to a high fat diet (LFD) yet, after prolonged exposure to the HFD, the effects resembled levels found with the LFD. This suggests that while a HFD may stimulate the effect of BAT, long term exposure may have adverse effects on BAT activity. This may be due to internal factors that will need to be examined further.
ContributorsSion, Paul William (Author) / Herman, Richard (Thesis director) / Borges, Chad (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The purpose of this study is to examine the effect of an existing medication management program in Hispanic individuals with diabetes, focusing on overall management and perceived quality of life (QOL). Diseases such as diabetes affect an individual's physical health, mental health, and social life. The degree to which these diseases affect an individual's life depend on how well they control and self-manage care needs. It has been found that Hispanic patients report and demonstrate inadequacy with controlling their diabetes compared to other ethnicities, making this an important public health topic (Schneiderman eta al., 2014). One of the greatest issues the Hispanic population reports as causing most concern is medication management and compliance. Poor medication adherence can increase complications of diabetes and depression, thus increasing poor overall health status and perception. Medication therapy management (MTM) programs run by clinical pharmacists are available to help with medication adherence, aiding in developing a tailored plan to help individuals manage the disease. This study is a cross-sectional study which assess reported QOL and functionality of diabetics enrolled in an MTM program. Participants were recruited from a clinic in Phoenix, Az. Patients completed a questionnaire that included demographics, a QOL questionnaire and a health belief questionnaire. A total of sixteen participants completed the study. The association between time in the medication therapy management program and its effect on general health, social functioning, emotional well-being, and hemoglobin A1C were reviewed. Though no significance was found, means were similar in all groups indicating functionality and A1C control through the diabetes support program may exist.
ContributorsVarela, Zury Arely (Author) / Flom-Racoma, Kehart (Thesis director) / Ohri-Vachaspati, Punam (Committee member) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
According to the CDC, diabetes is the 7th leading cause of death in the U.S. and rates are continuing to rise nationally and internationally. Chronically elevated blood glucose levels can lead to type 2 diabetes and other complications. Medications can be used to treat diabetes, but often have side effects. Lifestyle and diet modifications can be just as effective as medications in helping to improve glycemic control, and prevent diabetes or improve the condition in those who have it. Studies have demonstrated that consuming vinegar with carbohydrates can positively impact postprandial glycemia in diabetic and healthy individuals. Continuous vinegar intake with meals may even reduce fasting blood glucose levels. Since vinegar is a primary ingredient in mustard, the purpose of this study was to determine if mustard consumption with a carbohydrate-rich meal (bagel and fruit juice) had an effect on the postprandial blood glucose levels of subjects. The results showed that mustard improved glycemia by 17% when subjects consumed the meal with mustard as opposed to the control. A wide variety of vinegars exists. The defining ingredient in all vinegars is acetic acid, behind the improvement in glycemic response observed with vinegar ingestion. Vinegar-containing foods range from mustard, to vinaigrette dressings, to pickled foods. The benefits of vinegar ingestion with carbohydrates are dose-dependent, meaning that adding even small amounts to meals can help. Making a conscious effort to incorporate these foods into meals, in addition to an overall healthy lifestyle, could provide an additional tool for diabetics and nondiabetics alike to consume carbohydrates in a healthier manner.
ContributorsJimenez, Gabriela (Author) / Johnston, Carol (Thesis director) / Lespron, Christy (Committee member) / School of Nutrition and Health Promotion (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This is a creative thesis project on the topic of the third party logistics industry, and the improvements that are possible through the implementation of goods to person technologies. The scope of the project entails the relationship between Company X, which is a third party logistics provider, and Company Y, a major toy retailer. This thesis identifies current trends for the third party logistics industry such as rising operating costs and average savings achieved through these business relationships. After identifying the negative trends that Company X is vulnerable to such as high human resources costs, and cost of quality issues. Given the findings derived from industry data, a final recommendation was settled on to improve productivity and ultimately reduce the use of temporary labor for Company X. The implementation of a goods to person technology solution provides the opportunity to reduce hours of operation, man hours, as well as direct and indirect costs such as labor. Research has proven that firms operating in the retail industry rely heavily on temporary labor to handle the seasonal demand brought by the holidays, thus this recommendation could be applied to a variety of operations. The data compiled throughout this thesis have major implications for the third party logistics industry and achieving long term profitability in operations management.
ContributorsFonseca, Tanner (Author) / Printezis, Antonios (Thesis director) / Kellso, James (Committee member) / Department of Supply Chain Management (Contributor) / School of Sustainability (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This project details the synthesis and analysis of five analogs of model compound NEt-4IB (6-[ethyl(4-isobutoxy-3-isopropylphenyl)amino]nicotinic acid), that target the retinoid-X-receptor (RXR). These molecules were synthesized by substituting, adding, or removing substituents in the nitrogen-containing ring of NEt-4IB. The parent compound is a RXR partial agonist and has proven to be effective in the treatment of type II diabetes without the unwanted side effects seen with full agonists. Many of the current drugs used to treat type II diabetes are accompanied by adverse effects including increased triglyceride levels, weight gain, and hypoglycemia. Biological evaluation with KK-Ay (obese diabetic) model mice indicates that NEt-4IB may even be more effective than current drugs on the market, like pioglitazone. As a result, it is predicted that due to such structural similarity, the analogs synthesized for this work will perform equally, if not better than, NEt-4IB.
ContributorsMaiorella, Emma Lauren (Author) / Wagner, Carl (Thesis director) / Marshall, Pamela (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Diabetes is prevalent among the Latino population in the United States. Engagement in healthy dietary behaviors, especially as a young adult, is an effective means of reducing risk for diabetes. Previous psychological theories have demonstrated that health beliefs and perceived barriers influence engagement in such behaviors. This research investigated beliefs regarding risk for diabetes among the young, educated Latino population. Study 1 of this research sought to compare health beliefs and perceived barriers to barrier change in the young, educated Latino and European American populations. Latinos reported to have a higher perceived vulnerability to diabetes, but shared the belief in diet as the most important determinant of diabetes risk with European Americans. However, Latinos saw their diet as less malleable in their lives than did European Americans. Study 2 sought to replicate these findings and verify the existence of these beliefs. Young, educated Latinos' beliefs in the importance of diet yet a perceived lack of dietary changeability were confirmed. Furthermore, Study 2 evaluated the efficacy of health messages based in the principle of social proof in motivating health behavior change. Social proof, or social validation, describes the phenomenon in which people who see others similar to them engaging in a particular behavior are more likely to engage in that behavior. Latinos who were randomly assigned to receive a health message utilizing the principle of social proof to motivate healthy dietary changes were more likely to express a willingness to change their diet than those who did not receive such a message. These findings can inform the development of health campaigns seeking to promote healthy behaviors among young, educated Latinos.
ContributorsTowers, Michelle (Author) / Kwan, Virginia S. Y. (Thesis director) / Aiken, Leona S. (Committee member) / Williams, Deborah L. (Committee member) / Basilio, Camille D. (Committee member) / Barrett, The Honors College (Contributor)
Created2014-05
Description
Supply Chain Management has many fundamental principles that can be applied to all businesses to improve efficiency and create more transparency, this in turn, encourages collaboration and fosters healthy professional relationships. Using the fundamental principles of supply chain management, I evaluated the Veterans Administration(VA) hospital in regards to their provided treatment for Post-traumatic Stress Disorder(PTSD) to look for places where efficiency can be improved. I analyzed the problem in relation to Supply Chain Management, PTSD, and design in order to create a more complete solution. Once these areas were addressed, I proposed a solution that included creating a separate clinic for PTSD treatment that addressed the current issues in regards to treatment at the VA hospital. My goal was to improve space efficiencies and design a treatment environment that is more evolved and conducive to veterans suffering from PTSD. Though the creation of one PTSD clinic will not be able to completely change the system, it can be a step in the right direction to bring about the change that needs to occur within the VA medical system.
ContributorsGriffin, Kailey Anne (Author) / Brandt, Beverly (Thesis director) / Davila, Eddie (Committee member) / Damore-Minchew, Elizabeth (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / The Design School (Contributor)
Created2014-05
Description
This article summarizes exploratory research conducted on private and public hospital systems in Australia and Costa Rica analyzing the trends observed within supply chain procurement. Physician preferences and a general lack of available comparative effectiveness research—both of which are challenges unique to the health care industry—were found to be barriers to effective supply chain performance in both systems. Among other insights, the ability of policy to catalyze improved procurement performance in public hospital systems was also was observed. The role of centralization was also found to be fundamental to the success of the systems examined, allowing hospitals to focus on strategic rather than operational decisions and conduct value-streaming activities to generate increased cost savings.
ContributorsBudgett, Alexander Jay (Author) / Schneller, Eugene (Thesis director) / Gopalakrishnan, Mohan (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / Department of English (Contributor)
Created2015-05
Description
The rationale behind this thesis is grounded in nearly two years of experience interning at UTC Aerospace Systems (UTAS). I was able to gain a wide exposure to different facets of the supply chain management organization during my time as an intern, from strategic sourcing and commodity management, to tactical procurement and supplier development. In each of these respective areas, I observed a variety of initiatives that did not reach their full potential because employees were not provided the tools for success. One of these areas in particular is the New Product Introduction (NPI) process management, in which there is not a standard process for program managers to follow from start to finish. I saw this as an opportunity to hone in the scope of my thesis research and experience at UTAS to improve a process and provide standard work and tools for it to be consistently executed. The current state process is not formalized \u2014 it merely tracks certain metrics that are not necessarily applicable to the overall health of the program because they do not monitor the progress of the program. This resulted in heavy costs incurred from inadequate planning, a skewed timeline, and customer frustration. The aim of the desired state NPI process is to gather cross-functional expertise and weigh in, adhere to a strict entry to market timeline, and increase customer satisfaction, all while minimizing costs incurred throughout the life of the program. The dominant output of this project will be a cross-functional flow chart of the process for each group to follow and standard work and tools to support the process across a variety of NPI program applications.
ContributorsThorn, Taylor Aiko Marie (Author) / Brown, Steven (Thesis director) / Arrigoni, Gregory (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Supply Chain Management (Contributor) / W. P. Carey School of Business (Contributor)
Created2015-05
Description
The development of the Diabetic Physiological state is influenced by the Receptor for Advanced Glycation End Products (RAGE). This receptor was discovered in 1992, and the accumulation of research on this subject has been extensive. Structural characterization studies of the RAGE protein have shown that it is a transmembrane protein that binds a number of different motile ligands. The diversity of ligands that can attach to the binding domain is the primary factor that allows for RAGE to exhibit its wide-range effects on host cells. Two different studies were completed: one study dealt with the role of IAPP in beta cell death, and the second study was related to RAGE influence on cardiomyocytes and, more specifically, it was related to cardiac cell death. After the completion of the two studies, a comprehensive report was written for each topic. The two papers were merged into a single document. Molecular studies are important for understanding the underlying mechanisms that motivate pathophysiological presentation. In addition to a molecular understanding of the development of diabetes, a clinical research study was completed through the examination of appropriate literature sources. This clinical aspect allowed for the progression of different phases in the research process. A relationship between vinegar and lower plasma glucose was found. The exact mechanism behind this relationship will be studied in the future.
ContributorsGonzalez, Matthew Joseph (Author) / Johnston, Carol (Thesis director) / Collins, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor)
Created2015-05