Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

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The current study investigated whether intermittent restraint stress (IRS) would impair fear extinction learning and lead to increased anxiety and depressive- like behaviors and then be attenuated when IRS ends and a post- stress rest period ensues for 6 weeks. Young adult, male Sprague Dawley rats underwent restraint stress using

The current study investigated whether intermittent restraint stress (IRS) would impair fear extinction learning and lead to increased anxiety and depressive- like behaviors and then be attenuated when IRS ends and a post- stress rest period ensues for 6 weeks. Young adult, male Sprague Dawley rats underwent restraint stress using wire mesh (6hr/daily) for five days with two days off before restraint resumed for three weeks for a total of 23 restraint days. The groups consisted of control (CON) with no restraint other than food and water restriction yoked to the restrained groups, stress immediate (STR-IMM), which were restrained then fear conditioned soon after the end of the IRS paradigm, and stress given a rest for 6 weeks before fear conditioning commenced (STR-R6). Rats were fear conditioned by pairing a 20 second tone with a footshock, then given extinction training for two days (15 tone only on each day). On the first day of extinction, all groups discriminated well on the first trial, but then as trials progressed, STR-R6 discriminated between tone and context less than did CON. On the second day of extinction, STR- IMM froze more to context in the earlier trials than compared to STR-R6 and CON. As trials progressed STR-IMM and STR-R6 froze more to context than compared to CON. Together, CON discriminated between tone and context better than did STR-IMM and STR-R6. Sucrose preference, novelty suppressed feeding, and elevated plus maze was performed after fear extinction was completed. No statistical differences were observed among groups for sucrose preference or novelty suppressed feeding. For the elevated plus maze, STR-IMM entered the open arms and the sum of both open and closed arms fewer than did STR- R6 and CON. We interpret the findings to suggest that the stress groups displayed increased hypervigilance and anxiety with STR-R6 exhibiting a unique phenotype than that of STR-IMM and CON.
ContributorsShah, Vrishti Bimal (Author) / Conrad, Cheryl (Thesis director) / Newbern, Jason (Committee member) / Judd, Jessica (Committee member) / School of Life Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
Monoamine neurotransmitters (e.g., serotonin, norepinephrine, and dopamine) are powerful modulators of mood and cognitive function in health and disease. We have been investigating the modulation of monoamine clearance in select brain regions via organic cation transporters (OCTs), a family of nonselective monoamine transporters. OCTs are thought to complement the actions

Monoamine neurotransmitters (e.g., serotonin, norepinephrine, and dopamine) are powerful modulators of mood and cognitive function in health and disease. We have been investigating the modulation of monoamine clearance in select brain regions via organic cation transporters (OCTs), a family of nonselective monoamine transporters. OCTs are thought to complement the actions of selective monoamine transporters in the brain by helping to clear monoamines from the extracellular space; thus, assisting to terminate the monoamine signal. Of particular interest, stress hormones (corticosterone; CORT) inhibit OCT3-mediated transport of monoamine, to putatively lead to prolonged monoamine signaling. It has been demonstrated that stress levels of CORT block OCT3 transport in the rat hypothalamus, an effect that likely underlies the rapid, stress-induced increase in local monoamines. We examined the effect of chronic variable stress (CVS) on the development of mood disorders and OCT3 expression in limbic and hypothalamic regions of the rat brain. Animals subjected to CVS (14-days with random stressor exposure two times/day) showed reduced body weight gain, indicating that CVS was perceived as stressful. However, behavioral tests of anxiety and depressive-like behaviors in rats showed no group differences. Although there were no behavioral effects of stress, molecular analysis revealed that there were stress-related changes in OCT3 protein expression. In situ hybridization data confirmed that OCT3 mRNA is expressed in the hippocampus, amygdala, and hypothalamus. Analysis of Western blot data by two-way ANOVA revealed a significant treatment effect on OCT3 protein levels, with a significant decrease in OCT3 protein in the amygdala and hippocampus in CVS rats, compared to controls. These data suggest an important role for CORT sensitive OCT3 in the reduction of monoamine clearance during stress.
ContributorsBoyll, Piper Savannah (Author) / Orchinik, Miles (Thesis director) / Conrad, Cheryl (Committee member) / Talboom, Joshua (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
The goal of our study is to identify socio-economic risk factors for depressive disorder and poor mental health by statistically analyzing survey data from the CDC. The identification of risk groups in a particular demographic could aid in the development of targeted interventions to improve overall quality of mental health

The goal of our study is to identify socio-economic risk factors for depressive disorder and poor mental health by statistically analyzing survey data from the CDC. The identification of risk groups in a particular demographic could aid in the development of targeted interventions to improve overall quality of mental health in the United States. In our analysis, we studied the influences and correlations of socioeconomic factors that regulate the risk of developing Depressive Disorders and overall poor mental health. Using the statistical software STATA, we ran a regression model of selected independent socio-economic variables with the dependent mental health variables. The independent variables of the statistical model include Income, Race, State, Age, Marital Status, Sex, Education, BMI, Smoker Status, and Alcohol Consumption. Once the regression coefficients were found, we illustrated the data in graphs and heat maps to qualitatively provide visuals of the prevalence of depression in the U.S. demography. Our study indicates that the low-income and under-educated populations who are everyday smokers, obese, and/or are in divorced or separated relationships should be of main concern. A suggestion for mental health organizations would be to support counseling and therapeutic efforts as secondary care for those in smoking cessation programs, weight management programs, marriage counseling, or divorce assistance group. General improvement in alleviating poverty and increasing education could additionally show progress in counter-acting the prevalence of depressive disorder and also improve overall mental health. The identification of these target groups and socio-economic risk factors are critical in developing future preventative measures.
ContributorsGrassel, Samuel (Co-author) / Choueiri, Alexi (Co-author) / Choueiri, Robert (Co-author) / Goegan, Brian (Thesis director) / Holter, Michael (Committee member) / Sandra Day O'Connor College of Law (Contributor) / School of Molecular Sciences (Contributor) / School of Politics and Global Studies (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
This study examines the effectiveness of two modes of exercise on depression in adolescents with Down syndrome (DS). Thirty nine participants were randomly divided into a voluntary cycling group (VC) (i.e., self-selected cadence), an assisted cycling group (AC) (i.e., at least 30% faster than self-selected cadence accomplished by a motor),

This study examines the effectiveness of two modes of exercise on depression in adolescents with Down syndrome (DS). Thirty nine participants were randomly divided into a voluntary cycling group (VC) (i.e., self-selected cadence), an assisted cycling group (AC) (i.e., at least 30% faster than self-selected cadence accomplished by a motor), or a no exercise group (NC). In each cycling intervention the participant completed 30 minute cycling sessions, three times per week for a total of eight weeks. The Children's Depression Inventory II was administered prior to cycling (i.e., pretest) and after the eight week intervention (i.e., posttest). Although the data did not reach conventional levels of statistical significance, the results of the study demonstrated partial support for our hypothesis that adolescents with DS showed improvements in depression as measured by the Children's Depression Inventory II following assisted cycling, but not following eight weeks of voluntary cycling. In other words, eight weeks of moderate AC exercise demonstrated a trend for improved depression in adolescents with DS.
ContributorsMcgownd, Shana Leah (Author) / Ringenbach, Shannon (Thesis director) / Youngstedt, Shawn (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor)
Created2015-05
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Description
This piece aims to discuss the roles of emerging geographies within the context of global supply chains, approaching the conversation with a "systems" view, emphasizing three key facets essential to a holistic and interdisciplinary environmental analysis: -The Implications of Governmental & Economic Activities -Supply Chain Enablement Activities, Risk Mitigation in

This piece aims to discuss the roles of emerging geographies within the context of global supply chains, approaching the conversation with a "systems" view, emphasizing three key facets essential to a holistic and interdisciplinary environmental analysis: -The Implications of Governmental & Economic Activities -Supply Chain Enablement Activities, Risk Mitigation in Emerging Nations -Implications Regarding Sustainability, Corporate Social Responsibility In the appreciation of the interdisciplinary implications that stem from participation in global supply networks, supply chain professionals can position their firms for continued success in the proactive construction of robust and resilient supply chains. Across industries, how will supply networks in emerging geographies continue to evolve? Appreciating the inherent nuances related to the political and economic climate of a region, the extent to which enablement activities must occur, and sustainability/CSR tie-ins will be key to acquire this understanding. This deliverable aims to leverage the work of philosophers, researchers and business personnel as these questions are explored. The author will also introduce a novel method of teaching (IMRS) in the undergraduate business classroom that challenges the students to integrate their prior experiences both in the classroom and in the business world as they learn to craft locally relevant solutions to solve complex global problems.
ContributorsVaney, Rachel Lee (Author) / Maltz, Arnold (Thesis director) / Kellso, James (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / Department of Information Systems (Contributor)
Created2015-05
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Description
There is no doubt that globalization has been a force in history , and especially in the past one hundred years. This is extremely evident in the implications of global epidemics. The global response to Severe Acute Respiratory Syndrome (SARS) revealed tensions between nation states and international health organization such

There is no doubt that globalization has been a force in history , and especially in the past one hundred years. This is extremely evident in the implications of global epidemics. The global response to Severe Acute Respiratory Syndrome (SARS) revealed tensions between nation states and international health organization such as the World Health Organization) collectively called "Global Health Governance"). The issue was sovereignty. SARS showed us that there was more state-centric resistance to the Post-Westphalian world than previously thought. Where infectious diseases are concerned, however, the eventual compliance of states with the WHO shows reluctant but tacit compliance with international intervention.
ContributorsLaw, Stephanie (Author) / Rush, James (Thesis director) / Green, Monica (Committee member) / Lundry, Christopher (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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Description
Former two-time Costa Rican president Dr. Oscar Arias advocates for arms control between nations and, in some cases, complete disarmament as the first step in solving grave issues of international sustainability. The three spheres of sustainability—society, economy, and environment—are explained and the ultimate goal of the compromise between all

Former two-time Costa Rican president Dr. Oscar Arias advocates for arms control between nations and, in some cases, complete disarmament as the first step in solving grave issues of international sustainability. The three spheres of sustainability—society, economy, and environment—are explained and the ultimate goal of the compromise between all three aspects is defined as the means to achieving sustainability. A brief history of the politics and culture of Costa Rica provides a glimpse into the values and society of this Central American country, including a consistent commitment to the appreciation and protection of its natural environment. Dr. Arias is credited as one of the founding fathers of the sustainable development movement, as evidenced by his political career and policies both with Costa Rica and with other international communities. A selection of Dr. Arias’ speeches and conversations of the past four decades illuminates the need for disarmament and peaceful political interactions as the catalyst for human progress and sustainable development.
ContributorsZywicki, Alexandra (Author) / Alarcon, Justo (Thesis director) / Printezis, Antonios (Committee member) / Sullivan, Claire (Committee member) / Barrett, The Honors College (Contributor)
Created2015-05
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Description
In the current age, with media influence spreading through the entire world, formerly isolated regions and gated cultures became interconnected. With this globalization of culture came the communion between Japanese and Western media, especially animation and comics. Morality is often exemplified by heroes within a particular culture as figures for

In the current age, with media influence spreading through the entire world, formerly isolated regions and gated cultures became interconnected. With this globalization of culture came the communion between Japanese and Western media, especially animation and comics. Morality is often exemplified by heroes within a particular culture as figures for audiences to admire and draw values from, which can be a useful representation of that society's particular standards. The cultures' portrayal of heroism and morality through characterization and plot structure are emblematic not only of their original culture, but the new age of globalization as concepts previously considered unique to one region soon blended together through the world. From the Western "Hero's Journey" style mythos to the Japanese anime and manga heroes of the modern decades, we can see the growth and impact of globalization which caused new blends of portrayals and themes in revolutionary ways. The roots of the differences were found through research of popular culture and history of Japanese animation and Western comic books. Iconic Western comic book heroes such as Superman, Batman, and Wolverine are analyzed, followed by analysis and comparison to the Japanese parallel of the Japanese hero, specifically within Hirohiko Araki's acclaimed Jojo's Bizarre Adventure anime and manga franchise. Finally, the popular animated Western cartoon Avatar: The Last Airbender, known for its vast Eastern influence, meet the two worlds in the middle and epitomize the globalization of this concept of a hero's narrative. The purpose of this analysis is to understand the dynamics of cultural influence and cultural specificity, elucidating some stereotypes in contemporary culture brought by misconceptions and traditions in order to promote cross-cultural understanding.
ContributorsNguyen, Hau Trung (Author) / Wise, John MacGregor (Thesis director) / Wilson, Bradley (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
There has been a rise in the prevalence of mental health disorders among western industrialized populations.1 By 2020, depression will be second to heart disease in its contribution to the global burden of disease as measured by disability-adjusted life years.2 Anxiety disorders are the most common mental illness in the

There has been a rise in the prevalence of mental health disorders among western industrialized populations.1 By 2020, depression will be second to heart disease in its contribution to the global burden of disease as measured by disability-adjusted life years.2 Anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the United States ages 18 and older, or 18.1% of the U.S population every year.3
Mental disorders are prevalent in young adults and frequently present between 12-24 years of age.4 The top five sources of stress reported by college students were changes in sleeping routines, changes in eating habits, increased amount of work, new responsibilities, and breaks/vacations.5 Overall, a total of 73% of college students report occasional difficulties sleeping, and 48% of students suffer from sleep deprivation, as self-reported.6,7
Lifestyle factors such as diet, exercise and sleep may influence symptoms related to stress and depression.8 Symptoms of depression include but are not limited to, persistent anxious or sad moods, feeling guilty or helpless, loss of interest in hobbies, irritability, and other behaviors that may interrupt daily living.9 Inadequate intake of folic acid from fruits and vegetables, and essential fatty acids in fish, may increase symptoms of depression.10 Unhealthy eating habits may be associated with increases in depression-like symptoms in women, supporting the notion that healthier eating habits may decrease major depression.11 Diet is only one component of how lifestyle may influence depression and stress in adults. Exercise may be another important component in decreasing depression-related symptoms due to the release of endorphins.12 It has been found that participating in regular physical activity may decrease tension levels, increase and stabilize mood, improve self-esteem, and lead to better sleeping patterns.13 It has been concluded that individuals who consume a healthy diet are less likely to experience depression whereas people eating unhealthy and processed diets are more likely to be depressed.14
Poor sleep quality as well as unstable sleeping patterns may lead to poor psychological and physical health.15 Poor sleep includes longer duration of sleep onset latency, which is defined as the amount of time it takes to fall asleep, waking up multiple times throughout the night, and not getting a restful sleep because of tossing and turning.16 In healthy adults, the short-term consequences of sleep disruption consist of somatic pain, emotional destress and mood disorders, reduced quality of life, and increased stress responsivity.17 Irregular sleep-wake patterns, defined as taking numerous naps within a 24 hour span and not having a main nighttime sleep experience, are present at alarming levels (more than a quarter) among college students.18 A study done with 2,000 college students concluded that more than a quarter of the students were at risk of a sleeping disorder.19 Therefore, college students who were classified as poor-quality sleepers, reported experiencing more psychological and physical health problems compared to their healthy counterparts. Perceived stress was also found to be a factor in lower sleep quality of young adults.20
The link between depression-like symptoms and sleep remains poorly understood. It is mentioned that there are risk factors of poor sleep, depression and anxiety among college students but this topic has not yet been heavily studied within this population.
ContributorsBosnino, Jasmine (Co-author, Co-author) / Whisner, Corrie (Thesis director) / Petrov, Megan (Committee member) / Mahmood, Tara (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
Anxiety is currently the most prevalent mental disorder in America with over 4 million people struggling with it every day. I am one of those millions. This book explores the multitude of coping mechanisms that I have learned and developed through my time with anxiety, covering everything from humor to

Anxiety is currently the most prevalent mental disorder in America with over 4 million people struggling with it every day. I am one of those millions. This book explores the multitude of coping mechanisms that I have learned and developed through my time with anxiety, covering everything from humor to finding the motivation to change. It is a creative non-fiction autobiography that depicts detailed moments from my own life that provide advice and tools for managing anxiety that are made accessible to people who may have completely different experiences from my own. While anxiety has always played a huge roll in my life, it wasn't until I got to college that I decided to finally begin taking the steps I needed to in order to see the changes that I wanted to see. I am a teacher, and every day I see many of my students battling with the exact pains and stresses that I always have. This book is for all of my future students as well as all the adolescents out there who feel like nobody really understands; the ones who all they need is a little direction and the confidence to know they're not alone.
ContributorsSwendig, Laura Ashley (Author) / Blasingame, James (Thesis director) / Griffith, Jason (Committee member) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05