Barrett

Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

Displaying 1 - 2 of 2
Filtering by

Clear all filters

135698-Thumbnail Image.png

Modeling SDF-1α Chemotactic Gradient Formation After Traumatic Brain Injury

Description
Traumatic brain injury (TBI) is a leading cause of injury related death in the United States. The complexity of the injury environment that follows TBI creates an incomplete understanding of all the mechanisms in place to regulate chemotactic responses to TBI. The goal of this project was to develop a…

Traumatic brain injury (TBI) is a leading cause of injury related death in the United States. The complexity of the injury environment that follows TBI creates an incomplete understanding of all the mechanisms in place to regulate chemotactic responses to TBI. The goal of this project was to develop a predictive in silco model using diffusion and autocrine/paracrine signaling specific to stromal cell derived factor-1α (SDF-1α) gradient formation after TBI and compare this model with in vivo experimental data. A COMSOL model using Fickian diffusion and autocrine/paracrine reaction terms was generated to predict the gradient formation observed in vivo at three physiologically relevant time points (1, 3, and 7 days). In vivo data was gathered and analyzed via immunohistochemistry and MATLAB. The spatial distribution of SDF-1α concentration in vivo more consistently demonstrated patterns similar to the in silico model dependent on both diffusion and autocrine/paracrine reaction terms rather than diffusion alone. The temporal distribution of these same results demonstrated degradation of SDF-1α at too rapid a rate, compared to the in vivo results. To account for differences in behavior observed in vivo, reaction terms and constants of 1st-order reaction rates must be modulated to better reflect the results observed in vivo. These results from both the in silico model and in vivo data support the hypothesis that SDF-1α gradient formation after TBI depends on more than diffusion alone. Future work will focus on improving the model with constants that are specific to SDF-1α as well as testing methods to better control the degradation of SDF-1α.
ContributorsFreeman, Sabrina Louise (Author) / Stabenfeldt, Sarah (Thesis director) / Caplan, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
166201-Thumbnail Image.png

FIJI's Shave to Save: A Toolkit for Successful Fundraising by Charitable Organizations

Description

"FIJI's Shave to Save" took place in Fall 2021 when 47 members of Phi Gamma Delta (FIJI) at Arizona State University got their heads shaved as a public demonstration of the fraternity's commitment to the mission of the Translational Genomics Research Institute (TGen) and their Center for Rare Childhood Disorders…

"FIJI's Shave to Save" took place in Fall 2021 when 47 members of Phi Gamma Delta (FIJI) at Arizona State University got their heads shaved as a public demonstration of the fraternity's commitment to the mission of the Translational Genomics Research Institute (TGen) and their Center for Rare Childhood Disorders (the Center). Through tremendous community support, the majority of which came from members' families, FIJI alumni, and participating member sororities of Arizona State University's Panhellenic Council, we collectively raised $63,640 for the Center. These funds are directed towards the Center's groundbreaking research and efforts to improve the lives of children with rare disorders through genomic sequencing. Aside from the lives impacted by the fundraiser, this news was highlighted in publications from multiple media outlets and exhibited the positive impact that Greek Life is capable of. Months prior to this initiative, Taylor Dintzner (2021 Chapter President) and Cameron Chew (2021 Philanthropy Chairman) were lost and did not know how to approach the execution of a successful fundraiser. In December 2021, they met with Rob Caudill, Executive Director at the International Headquarters of Phi Gamma Delta (FIJI), to discuss international publicity for the initiative. The verdict was that other FIJI Chapters may benefit from a "toolkit" that details how FIJI at Arizona State University was able to raise $63,500 for TGen. "FIJI's Shave to Save: A Toolkit for Successful Fundraising by Charitable Organizations" is intended to be a resource that encourages FIJI Chapters internationally to execute their own "FIJI's Shave to Save" initiative, giving them all of the tools necessary to follow a similar format and raise funds for TGen's Center for Rare Childhood Disorders. Media Highlighting FIJI at Arizona State University's Community Impact: https://linktr.ee/fijigraduatechapter
ContributorsDintzner, Taylor (Author) / Ballinger, Gary (Thesis director) / Vogel, Joanne (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor)
Created2022-05