Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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Description
Traumatic brain injury (TBI) is a leading cause of injury related death in the United States. The complexity of the injury environment that follows TBI creates an incomplete understanding of all the mechanisms in place to regulate chemotactic responses to TBI. The goal of this project was to develop a predictive in silco model using diffusion and autocrine/paracrine signaling specific to stromal cell derived factor-1α (SDF-1α) gradient formation after TBI and compare this model with in vivo experimental data. A COMSOL model using Fickian diffusion and autocrine/paracrine reaction terms was generated to predict the gradient formation observed in vivo at three physiologically relevant time points (1, 3, and 7 days). In vivo data was gathered and analyzed via immunohistochemistry and MATLAB. The spatial distribution of SDF-1α concentration in vivo more consistently demonstrated patterns similar to the in silico model dependent on both diffusion and autocrine/paracrine reaction terms rather than diffusion alone. The temporal distribution of these same results demonstrated degradation of SDF-1α at too rapid a rate, compared to the in vivo results. To account for differences in behavior observed in vivo, reaction terms and constants of 1st-order reaction rates must be modulated to better reflect the results observed in vivo. These results from both the in silico model and in vivo data support the hypothesis that SDF-1α gradient formation after TBI depends on more than diffusion alone. Future work will focus on improving the model with constants that are specific to SDF-1α as well as testing methods to better control the degradation of SDF-1α.
ContributorsFreeman, Sabrina Louise (Author) / Stabenfeldt, Sarah (Thesis director) / Caplan, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis project had three key components. First, we performed an extensive literature review of different types of feminist theories to better understand the scope of their definitions. We also reviewed several articles that examined how women, especially Latinas, seek to understand and negotiate their identity as feminists. Second, we conducted qualitative interviews with Latina college women in which they shared their college experiences, their thoughts on feminism, and how they believe the cultural values they were brought up with play a role in both. Finally, we developed a 12-minute documentary film containing excerpts from participants’ interviews that reflected a number of core themes. We invited participants to view the documentary and contribute to a post-film conversation with interested faculty members and students. The interactive post-film conversation served as a reflection and expansion of the themes in the film and challenged those that participated to explore avenues of resolution through family and communication.
The motivation for this project came from a place of reflection for what it means to be a feminist and Latina and how to navigate the values of both without compromising one over the other. After personally contemplating the meanings and process without coming to a concrete understanding, we were prompted to branch out and engage other Latina college students in a conversation about what it means for them, what unique challenges they may be facing, and how they may be seeking to answer questions surrounding their identity.
The motivation for this project came from a place of reflection for what it means to be a feminist and Latina and how to navigate the values of both without compromising one over the other. After personally contemplating the meanings and process without coming to a concrete understanding, we were prompted to branch out and engage other Latina college students in a conversation about what it means for them, what unique challenges they may be facing, and how they may be seeking to answer questions surrounding their identity.
ContributorsAlvarado, Ismail G. (Co-author) / Alejandro, Nathalie (Co-author) / Hall, Deborah (Thesis director) / Villegas-Silva, Claudia (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05