Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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Description
Traumatic brain injury (TBI) is a leading cause of injury related death in the United States. The complexity of the injury environment that follows TBI creates an incomplete understanding of all the mechanisms in place to regulate chemotactic responses to TBI. The goal of this project was to develop a predictive in silco model using diffusion and autocrine/paracrine signaling specific to stromal cell derived factor-1α (SDF-1α) gradient formation after TBI and compare this model with in vivo experimental data. A COMSOL model using Fickian diffusion and autocrine/paracrine reaction terms was generated to predict the gradient formation observed in vivo at three physiologically relevant time points (1, 3, and 7 days). In vivo data was gathered and analyzed via immunohistochemistry and MATLAB. The spatial distribution of SDF-1α concentration in vivo more consistently demonstrated patterns similar to the in silico model dependent on both diffusion and autocrine/paracrine reaction terms rather than diffusion alone. The temporal distribution of these same results demonstrated degradation of SDF-1α at too rapid a rate, compared to the in vivo results. To account for differences in behavior observed in vivo, reaction terms and constants of 1st-order reaction rates must be modulated to better reflect the results observed in vivo. These results from both the in silico model and in vivo data support the hypothesis that SDF-1α gradient formation after TBI depends on more than diffusion alone. Future work will focus on improving the model with constants that are specific to SDF-1α as well as testing methods to better control the degradation of SDF-1α.
ContributorsFreeman, Sabrina Louise (Author) / Stabenfeldt, Sarah (Thesis director) / Caplan, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The way the public perceives law enforcement influences how communities function. Identifying how individuals develop their perceptions of law enforcement is critically important. Mainly, their experiences with officers determine how perceptions of law enforcement are developed. Analyzing perceptions of law enforcement can help people understand relationships that officers have with community members and determine the type of impact that officers have on certain populations such as the youth. This study examines youth perceptions of law enforcement. The youths’ perception of police is an important perception to analyze. It is important because their perceptions have the power to create change or influence other people their age. It has been seen that the youth “create meaningful institutional change in their communities”. The research and findings on perceptions of law enforcement are important because they could help explain whether there is a correlation between crime rates in the community and perceptions of law enforcement from community members. It can also help identify how much the youth population is willing to rely on law enforcement and whether they trust and respect them. The youth are exposed to factors in their community that can influence certain attitudes and perspectives. In this research, a study from Elementary schools in Compton, CA is analyzed to identify youth perceptions of law enforcement. The research questions addressed are: Is there any correlation between crime rates in the community and perceptions of law enforcement? Can a program implemented into schools improve youth perceptions of law enforcement? How much are the youth willing to rely on law enforcement?
ContributorsRodriguez Villarreal, Elizabeth (Author) / Fine, Adam (Thesis director) / Trinkner, Rick (Committee member) / School of Criminology and Criminal Justice (Contributor, Contributor) / School of Social Work (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05