Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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Description
Traumatic brain injury (TBI) is a leading cause of injury related death in the United States. The complexity of the injury environment that follows TBI creates an incomplete understanding of all the mechanisms in place to regulate chemotactic responses to TBI. The goal of this project was to develop a predictive in silco model using diffusion and autocrine/paracrine signaling specific to stromal cell derived factor-1α (SDF-1α) gradient formation after TBI and compare this model with in vivo experimental data. A COMSOL model using Fickian diffusion and autocrine/paracrine reaction terms was generated to predict the gradient formation observed in vivo at three physiologically relevant time points (1, 3, and 7 days). In vivo data was gathered and analyzed via immunohistochemistry and MATLAB. The spatial distribution of SDF-1α concentration in vivo more consistently demonstrated patterns similar to the in silico model dependent on both diffusion and autocrine/paracrine reaction terms rather than diffusion alone. The temporal distribution of these same results demonstrated degradation of SDF-1α at too rapid a rate, compared to the in vivo results. To account for differences in behavior observed in vivo, reaction terms and constants of 1st-order reaction rates must be modulated to better reflect the results observed in vivo. These results from both the in silico model and in vivo data support the hypothesis that SDF-1α gradient formation after TBI depends on more than diffusion alone. Future work will focus on improving the model with constants that are specific to SDF-1α as well as testing methods to better control the degradation of SDF-1α.
ContributorsFreeman, Sabrina Louise (Author) / Stabenfeldt, Sarah (Thesis director) / Caplan, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Though often viewed as a positive aspect of past, modern, and future interpersonal interaction, communities can be viewed under a microscope as a tool used by the human species to preserve oneself. Communities are used as a safety tool to assure the longevity of an individual. As a dancer and dancemaker, taking part in the art of dance challenges one's perception of large groups of bodies taking up space. Following a global pandemic, dancers and people alike were forced to find communities of much smaller sizes to appease the need to interact with other people. This caused the creation of safety pods and the urge to connect with others in ways that were not always favored. How did individuals suffer from a lack of interpersonal connection? Does the need for communities highlight a higher level of codependency amongst individuals who prefer relying on communities? Is this morally wrong? This thesis uses research obtained from ethical theories, travel research, and movement research to determine whether or not this action is morally right or wrong. This thesis uses an ethnographic style of writing to navigate through the creative process of dancemaking for an evening-length dance show, further analyzing the individual need for communities. This reflective writing defends the thesis and includes new revelations on the topic of communities and self-preservation.
ContributorsKing, Takela (Author) / Lerman, Elizabeth (Thesis director) / Koch, Carolyn (Committee member) / Barrett, The Honors College (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / School of Music, Dance and Theatre (Contributor)
Created2022-05