Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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- All Subjects: Alzheimer's Disease
Description
Dementia is a progressive, neurodegenerative disease for which there is no cure at the present time. Patients with dementia and age-related disorders experience neuropsychiatric symptoms such as delusions, hallucinations, and other difficult to handle behaviors (Peipert et al., 2018). Due to the staggering cost of hiring in-home help or placing their loved ones in a memory care facility, many Americans choose to care for their loved one at home. Unfortunately, this undertaking can impact the caregiver’s emotional and mental health, financial situation, and social life (Peipert et al., 2018). Psychosocial interventions, ranging from social support to therapy, have been shown to be incredibly effective in improving dementia caregiver mental health. One such psychosocial intervention is Cognitive-Behavioral Therapy. Cognitive-Behavioral Therapy (CBT) helps the individual adapt more effective thinking patterns in order to improve their coping skills (Kwon et al., 2017). CBT combines cognitive theory and behavioral theory to explain how our thoughts and feelings directly impact the severity of a situation. In cognitive theory, it is our interpretation of the events that happen to us that is the root of our emotions, not the events themselves. The relationship between our interpretation and our emotions is known as the ABC model (Sorocco & Lauderdale, 2011). In this paper, several relevant studies researching the impacts of CBT on family dementia caregiver stress and burden are assessed and reviewed. A comprehensive, tentative CBT plan for family dementia caregivers is included and proposed.
ContributorsVan Duine, Kelly Nicole (Author) / Infurna, Frank (Thesis director) / Baker, Zach (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / School of International Letters and Cultures (Contributor)
Created2024-05
Description
In today's dynamic societal landscape, the critical evaluation of public policies holds paramount importance. This thesis project, undertaken by a Barrett Honors student of Public Policy, endeavors to contribute to this essential discourse by creating a policy critique podcast.
The primary objective of this project is to produce two podcast episodes that delve into the intricacies of housing policy. Through a meticulous examination, these episodes will dissect the implications of the selected housing policy. By offering a nuanced perspective, the podcast aims to illuminate the complexities inherent in housing policy issues, enriching the understanding of listeners.
This thesis project represents a scholarly endeavor to engage in informed discussions about the efficacy and implications of policies, specifically housing policies. Through the medium of podcasting, the project seeks to bridge the gap between academic research and public discourse to foster a deeper understanding of housing policy among a diverse audience.
Ultimately, this thesis project aims to contribute to the ongoing dialogue surrounding public policies, particularly in the realm of housing policy, by providing listeners with valuable insights and fostering critical thinking about contemporary policy challenges.
ContributorsCruz, Corinn (Author) / Uebelherr, Joshua (Thesis director) / Gaughan, Monica (Committee member) / Barrett, The Honors College (Contributor) / School of Public Affairs (Contributor)
Created2024-05
ContributorsCruz, Corinn (Author) / Uebelherr, Joshua (Thesis director) / Gaughan, Monica (Committee member) / Barrett, The Honors College (Contributor) / School of Public Affairs (Contributor)
Created2024-05
ContributorsCruz, Corinn (Author) / Uebelherr, Joshua (Thesis director) / Gaughan, Monica (Committee member) / Barrett, The Honors College (Contributor) / School of Public Affairs (Contributor)
Created2024-05
Description
Neuroinflammation contributes significantly to the pathogenesis of Alzheimer’s and Parkinson’s diseases. However, the inflammatory pathways contributing to neurodegeneration are not well understood. Moreover, there is a need to identify changes in inflammatory signaling that may occur early in disease progression to identify potential targets for therapeutic intervention. An important step towards addressing this need is understanding how the extracellular vesicles (EVs) released by microglia can be detected in the periphery. For microglia, phagocytic macrophages, and CD 14+ monocytes share many genes and membrane- bound proteins, and there is currently no method to distinguish microglia EVs from those generated by macrophages or monocytes. Therefore, this study aims to identify membrane-bound proteins unique to microglia EVs to enable their reliable isolation. Liquid-chromatography tandem mass spectrometry analysis was used to detect proteins in the EVs from both normal and disease-associated human stem-cell differentiated microglia (iMGL), and human induced pluripotent stem cell-derived CD 14+ monocytes and macrophages. We identified 23 proteins unique to the microglial EVs, eight of which localize to the membrane and may be potential targets for isolation. This investigation also used RNA sequencing to gain insight into the contents of DAM-like and control iMGL EVs and of microglia and white blood cells in Alzheimer’s disease. We propose that the contents of microglial EVs isolated from peripheral compartments will provide crucial insight for understanding the current inflammatory state of CNS microglia. This approach could provide a means to track changes in microglial activation over time, which is critical for understanding the progression of neuroinflammatory diseases like Alzheimer's and Parkinson's. Additionally, it may offer insights into potential therapeutic targets for modulating neuroinflammation.
ContributorsLopatin, Ulia (Author) / Mastroeni, Diego (Thesis director) / Velazquez, Ramon (Committee member) / Van Keuren-Jensen, Kendall (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
Alzheimer's disease (AD) is characterized by the progressive loss of cognitive function and memory, and is the most common cause of dementia. Alzheimer's disease targets the brain and is associated with the accumulation of abnormal protein aggregates that disrupt neural network communication and lead to various facets of cognitive decline. Current problems in AD research originates from the inability to identify individuals that are at risk. With the limitations of patients already displaying signs of neurodegeneration, strategies for prevention are not effective. Through developing a comprehensive cognitive test that tests a range of mental abilities, data can be collected, and a longitudinal study can be proposed to track cognitive decline in a multifaceted approach over a period of time. Previous literature indicates that functional decline is present years before the manifestation of symptoms in Alzheimer’s disease. Identifying pre-diagnostic cognitive and functional changes could lead to an improved and wider selection for preventive treatment trials. By designing a comprehensive cognitive experiment, an initial data set was obtained, and trends related to time and answer response were analyzed. The scope, applications and limitations within this experimental design is discussed, and future directions are proposed.
ContributorsDale, Anna (Author) / Hartwell, Leland (Thesis director) / Huseby, Carol (Committee member) / Barrett, The Honors College (Contributor) / School of Music, Dance and Theatre (Contributor) / School of Life Sciences (Contributor)
Created2023-12
Description
Objective: To examine the change in caregiver burden, stress, and heart rate variability (HRV) scores when family caregivers (FCG) of patients with Alzheimer’s disease (AD) used heart rate variability biofeedback (HRVB). Additional factors that could potentially moderate the effects of HRVB, such as education and income level, were separately examined.
Methods: An 8-week HRVB intervention was compared to a music listening control (MLC) condition for 30 family caregivers (FCGs) of individuals with Alzheimer’s disease (AD) (and related dementias: ADRD). Analysis per education and income level were separately conducted.
Results: The HRVB intervention with higher education and lower-income individuals showed more favorable HRV outcomes (noted to be slightly decreased in higher-income individuals). Perceived stress was reduced for both intervention groups, and caregiver burden levels decreased for all income groups, particularly in those with lower incomes.
Discussion: Future researchers should increase the sample size, explore stratification based on income and education levels, and consider gender-based divisions, as these factors could yield valuable insights.
ContributorsMathews, Megan (Author) / Vizcaino, Maricarmen (Thesis director) / Larkey, Linda (Committee member) / James, Darith (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2023-12
ContributorsMathews, Megan (Author) / Vizcaino, Maricarmen (Thesis director) / Larkey, Linda (Committee member) / James, Darith (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2023-12
ContributorsMathews, Megan (Author) / Vizcaino, Maricarmen (Thesis director) / Larkey, Linda (Committee member) / James, Darith (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2023-12
Description
The Crystals in All of Us is a children's book creative project that is meant to reflect the impact a community has on a child, and vice versa. Made specifically for the special needs students I work with, it is a generalizable lesson. It incorporates various art principles, as well as child and human development theories, such as Vygotsky's Zone of Proximal Development.
ContributorsRoodettes, Nicolas (Author) / Fonseca-Chavez, Vanessa (Thesis director) / Williams, Wendy (Committee member) / Barrett, The Honors College (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Division of Teacher Preparation (Contributor)
Created2023-12