Barrett

Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.

Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.

Displaying 131 - 137 of 137
Filtering by

Clear all filters

Investigating the Role of Epidermal Growth Factor Receptor Activation and Endoplasmic Reticulum Stress on Intracranial Aneurysm Rupture

Description

In intracranial aneurysms, multiple factors and biochemical pathways are believed to be involved in the event of a rupture. The epidermal growth factor receptor (EGFR) activation pathway is of particular interest as a way to understand and target the mechanism of rupture due to its established role in cellular proliferation…

In intracranial aneurysms, multiple factors and biochemical pathways are believed to be involved in the event of a rupture. The epidermal growth factor receptor (EGFR) activation pathway is of particular interest as a way to understand and target the mechanism of rupture due to its established role in cellular proliferation and inflammation. Furthermore, unfolded protein responses in vascular cells’ endoplasmic reticulum (ER), known as ER stress, have emerged as a potential downstream mechanism by which inflammatory EGFR activation may lead to aneurysm rupture. The purpose of this project was to investigate the role of EGFR inhibition on the aneurysm rupture rate in a preclinical model, investigate the role of ER stress induction on the aneurysm rupture rate, and confirm which cellular phenomenon lies upstream in this mechanistic cascade. Based on analyses of aneurysm rupture rate and gene expression in the Circle of Willis, ER stress and inflammatory unfolded protein responses were found to be downstream of initial EGFR activation, which may be an effective therapeutic target for preventing aneurysm rupture in a clinical setting.
ContributorsPolen, Kyle (Author) / Van Horn, Wade (Thesis director) / Martin, Thomas (Committee member) / Hashimoto, Tomoki (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2022-12

The Transfer Experience: Overcoming Barriers And Paving The Path To Success

Description

Students who transfer to a university from a community college are a diverse, resilient group of individuals who often face many challenges and barriers upon transitioning from a 2-year institution to a 4-year institution. Due to their upper-division status upon arrival at the university, transfer students are often overlooked and…

Students who transfer to a university from a community college are a diverse, resilient group of individuals who often face many challenges and barriers upon transitioning from a 2-year institution to a 4-year institution. Due to their upper-division status upon arrival at the university, transfer students are often overlooked and even unsupported throughout multiple aspects of the transfer process. To further understand the issues that are faced by transfer students throughout the transfer process, we conducted research to get a better understanding of exactly who transfer students are, what challenges they face, and how universities can better support these students so they are able to complete their baccalaureate. We compiled this research into an annotated bibliography and developed a presentation to discuss our findings, personal anecdotes, and the suggestions we have to help Barrett, the Honors College move towards a more transfer-receptive culture. All questions asked during the presentation have been documented.
ContributorsAutote, Abreanna (Author) / Loera, Cristian Peter (Co-author) / Ingram-Waters, Mary (Thesis director) / Abril, Lauren (Committee member) / Hugh Downs School of Human Communication (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05

The Transfer Experience: Overcoming Barriers And Paving The Path To Success

Description

Students who transfer to a university from a community college are a diverse, resilient group of individuals who often face many challenges and barriers upon transitioning from a 2-year institution to a 4-year institution. Due to their upper-division status upon arrival at the university, transfer students are often overlooked and…

Students who transfer to a university from a community college are a diverse, resilient group of individuals who often face many challenges and barriers upon transitioning from a 2-year institution to a 4-year institution. Due to their upper-division status upon arrival at the university, transfer students are often overlooked and even unsupported throughout multiple aspects of the transfer process. To further understand the issues that are faced by transfer students throughout the transfer process, we conducted research to get a better understanding of exactly who transfer students are, what challenges they face, and how universities can better support these students so they are able to complete their baccalaureate. We compiled this research into an annotated bibliography and developed a presentation to discuss our findings, personal anecdotes, and the suggestions we have to help Barrett, the Honors College move towards a more transfer-receptive culture. All questions asked during the presentation have been documented.
ContributorsLoera, Cristian Peter (Author) / Autote, Aubreanna (Co-author) / Ingram-Waters, Mary (Thesis director) / Abril, Lauren (Committee member) / Hugh Downs School of Human Communication (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05

The Crystals in All of Us

Description
The Crystals in All of Us is a children's book creative project that is meant to reflect the impact a community has on a child, and vice versa. Made specifically for the special needs students I work with, it is a generalizable lesson. It incorporates various art principles, as well…

The Crystals in All of Us is a children's book creative project that is meant to reflect the impact a community has on a child, and vice versa. Made specifically for the special needs students I work with, it is a generalizable lesson. It incorporates various art principles, as well as child and human development theories, such as Vygotsky's Zone of Proximal Development.
ContributorsRoodettes, Nicolas (Author) / Fonseca-Chavez, Vanessa (Thesis director) / Williams, Wendy (Committee member) / Barrett, The Honors College (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Division of Teacher Preparation (Contributor)
Created2023-12

Growing Community: An Examination of Mercy Hill Church Strategic Messaging Focusing on Instagram and Facebook

Description
The Southern Baptist Convention’s missional branch, North American Mission Board, and their church planting subsidiary, Send Network, failed to provide online communication guidance to help establish (or plant) new faith communities. Only 13% of Evangelical Protestants are under the age of thirty (Pew Research Center, 2015). If the Southern Baptist…

The Southern Baptist Convention’s missional branch, North American Mission Board, and their church planting subsidiary, Send Network, failed to provide online communication guidance to help establish (or plant) new faith communities. Only 13% of Evangelical Protestants are under the age of thirty (Pew Research Center, 2015). If the Southern Baptist Convention wants their church plants to grow in a media-focused society, they must learn how to communicate with the generations who were born with technology in their hands. The purpose of this study is to identify which content and frequency Southern Baptist Churches in Metropolitan Phoenix should use to reach their target community. The project began by conducting research on twelve Send Network church plants within fifteen miles of the center of downtown Phoenix. The results led to drafting a communications and branding guideline for one of the Send Network’s church plants, Mercy Hill Church, creating a ten-week posting schedule to collect insights on content and frequency of posts, analyzing and identifying best practices for its social media strategy and tactics. The ideal posting schedule and ratio of still image and video content for Mercy Hill Church on Instagram and Facebook was revealed. Additionally, it was identified the best day of the week to publish each type of post out of these seven: community, Scripture, worship, testimony, ministry highlight, sermon recap and church invite. Overall, the project determined that a consistent and cohesive Instagram and Facebook posting schedule increased traditional college-aged student engagement with Mercy Hill Church. It also resulted in an ideal posting schedule for Southern Baptist church plants if their target audience includes traditional college-aged students.
ContributorsDellaripa, Amelia (Author) / Matera, Frances (Thesis director) / Hass, Mark (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor)
Created2023-12

The Loop: Connecting People and Building Communities

Description
With the reality that 60% of post-graduates are less satisfied with their social life in adulthood than in college, many young adults find themselves searching to solve the shared fear of finding communities in new spheres of life. Jillian Cote and Mia Cavalier's social application concept, "The Loop", addresses this…

With the reality that 60% of post-graduates are less satisfied with their social life in adulthood than in college, many young adults find themselves searching to solve the shared fear of finding communities in new spheres of life. Jillian Cote and Mia Cavalier's social application concept, "The Loop", addresses this problem through unique recommendations based on location services, authentic UGC, and entertaining digital appearances. Through extensive research and development, a prototype has been designed for the application interface, and intensive surveys and interviews have been conducted to pinpoint target markets, consumer interest, and ultimate adoption potential. At its core, "The Loop" is a modern, efficient, and functional social application for young adults and post-graduates to stay connected to key parts of their lives regardless of the life phase they’re in. It allows each individual to focus on what’s important to them, while the app keeps them in the loop for everything else.
ContributorsCote, Jillian (Author) / Cavalier, Mia (Co-author) / Byrne, Jared (Thesis director) / Swader, Melissa (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / Department of Marketing (Contributor)
Created2024-05

Exploring polyamine biosynthesis as a therapeutic vulnerability in medulloblastoma

Description
Medulloblastoma is the most common pediatric brain cancer and accounts for 20% of all pediatric brain tumors. Upon diagnosis, patients undergo tumor-resection surgery followed by intense chemotherapy and cerebrospinal irradiation (CSI) regimens. CSI therapy is highly toxic and poorly tolerated in pediatric patients and is known to cause long-term neurocognitive,…

Medulloblastoma is the most common pediatric brain cancer and accounts for 20% of all pediatric brain tumors. Upon diagnosis, patients undergo tumor-resection surgery followed by intense chemotherapy and cerebrospinal irradiation (CSI) regimens. CSI therapy is highly toxic and poorly tolerated in pediatric patients and is known to cause long-term neurocognitive, endocrine, and developmental deficits that often diminish the quality of life for medulloblastoma patients. The development of targeted therapies is necessary for both increasing the chance of survival and reducing treatment-related morbidities. A potential therapeutic target of interest in medulloblastoma is the polyamine biosynthesis pathway. Polyamines are metabolites present in every living organism and are essential for cellular processes such as growth, survival, and differentiation. Recent studies have shown that polyamine production is dysregulated in several cancers, including brain cancers, and have highlighted polyamine biosynthesis as a potential cancer growth dependency. Dysregulated polyamine metabolism has also been linked to several oncogenic drivers, including the WNT, SHH, and MYC signaling pathways that characterize genetically distinct medulloblastoma subgroups. One way to target polyamine biosynthesis is through the inhibition of the rate-limiting enzyme ornithine decarboxylase with difluoromethylornithine (DFMO), an analog of the polyamine precursor ornithine. DFMO is well-tolerated in pediatric populations and exerts minimal toxicities, as shown through neuroblastoma clinical trials, and is a therapy of interest for medulloblastoma. While DFMO has been tested clinically in multiple cancers, few in vitro studies have been performed to understand the exact mechanisms of anti-proliferation and cytotoxicity. Our study screened two immortalized medulloblastoma cell lines, DAOY (SHH) and D283 (non-WNT/non-SHH), and three patient-derived medulloblastoma cell lines, SL00024 (SHH), SL00668 (non-WNT/non-SHH), SL00870 (Unknown subgroup), for DFMO sensitivity and profiled the immortalized medulloblastoma cell line metabolome to understand the interactions between inhibition of polyamine metabolism with other essential metabolic processes and tumor cell growth. We found that medulloblastoma cell lines are sensitive to DFMO and the adaptive response to DFMO in medulloblastoma may be caused by increased oxidative stress and free radical scavenging. Our study hopes to inform the use of DFMO as an anti-cancer therapy in medulloblastoma by understanding the drug’s single-agent anti-proliferative mechanisms.
ContributorsFain, Caitlyn (Author) / Buetow, Kenneth (Thesis director) / Pirrotte, Patrick (Committee member) / Pathak, Khyati (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2024-05