Barrett, The Honors College Thesis/Creative Project Collection
Barrett, The Honors College at Arizona State University proudly showcases the work of undergraduate honors students by sharing this collection exclusively with the ASU community.
Barrett accepts high performing, academically engaged undergraduate students and works with them in collaboration with all of the other academic units at Arizona State University. All Barrett students complete a thesis or creative project which is an opportunity to explore an intellectual interest and produce an original piece of scholarly research. The thesis or creative project is supervised and defended in front of a faculty committee. Students are able to engage with professors who are nationally recognized in their fields and committed to working with honors students. Completing a Barrett thesis or creative project is an opportunity for undergraduate honors students to contribute to the ASU academic community in a meaningful way.
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Description
Monoamine neurotransmitters (e.g., serotonin, norepinephrine, and dopamine) are powerful modulators of mood and cognitive function in health and disease. We have been investigating the modulation of monoamine clearance in select brain regions via organic cation transporters (OCTs), a family of nonselective monoamine transporters. OCTs are thought to complement the actions of selective monoamine transporters in the brain by helping to clear monoamines from the extracellular space; thus, assisting to terminate the monoamine signal. Of particular interest, stress hormones (corticosterone; CORT) inhibit OCT3-mediated transport of monoamine, to putatively lead to prolonged monoamine signaling. It has been demonstrated that stress levels of CORT block OCT3 transport in the rat hypothalamus, an effect that likely underlies the rapid, stress-induced increase in local monoamines. We examined the effect of chronic variable stress (CVS) on the development of mood disorders and OCT3 expression in limbic and hypothalamic regions of the rat brain. Animals subjected to CVS (14-days with random stressor exposure two times/day) showed reduced body weight gain, indicating that CVS was perceived as stressful. However, behavioral tests of anxiety and depressive-like behaviors in rats showed no group differences. Although there were no behavioral effects of stress, molecular analysis revealed that there were stress-related changes in OCT3 protein expression. In situ hybridization data confirmed that OCT3 mRNA is expressed in the hippocampus, amygdala, and hypothalamus. Analysis of Western blot data by two-way ANOVA revealed a significant treatment effect on OCT3 protein levels, with a significant decrease in OCT3 protein in the amygdala and hippocampus in CVS rats, compared to controls. These data suggest an important role for CORT sensitive OCT3 in the reduction of monoamine clearance during stress.
ContributorsBoyll, Piper Savannah (Author) / Orchinik, Miles (Thesis director) / Conrad, Cheryl (Committee member) / Talboom, Joshua (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The goal of our study is to identify socio-economic risk factors for depressive disorder and poor mental health by statistically analyzing survey data from the CDC. The identification of risk groups in a particular demographic could aid in the development of targeted interventions to improve overall quality of mental health in the United States. In our analysis, we studied the influences and correlations of socioeconomic factors that regulate the risk of developing Depressive Disorders and overall poor mental health. Using the statistical software STATA, we ran a regression model of selected independent socio-economic variables with the dependent mental health variables. The independent variables of the statistical model include Income, Race, State, Age, Marital Status, Sex, Education, BMI, Smoker Status, and Alcohol Consumption. Once the regression coefficients were found, we illustrated the data in graphs and heat maps to qualitatively provide visuals of the prevalence of depression in the U.S. demography. Our study indicates that the low-income and under-educated populations who are everyday smokers, obese, and/or are in divorced or separated relationships should be of main concern. A suggestion for mental health organizations would be to support counseling and therapeutic efforts as secondary care for those in smoking cessation programs, weight management programs, marriage counseling, or divorce assistance group. General improvement in alleviating poverty and increasing education could additionally show progress in counter-acting the prevalence of depressive disorder and also improve overall mental health. The identification of these target groups and socio-economic risk factors are critical in developing future preventative measures.
ContributorsGrassel, Samuel (Co-author) / Choueiri, Alexi (Co-author) / Choueiri, Robert (Co-author) / Goegan, Brian (Thesis director) / Holter, Michael (Committee member) / Sandra Day O'Connor College of Law (Contributor) / School of Molecular Sciences (Contributor) / School of Politics and Global Studies (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
ContributorsDolan, Kattie (Author) / Leong, Karen (Thesis director) / Wilson, Bradley (Committee member) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Information Measurement Theory (IMT) is a concept which was devised for the purpose of understanding how information works in the universe. At its core, it states that 100% of information exists in the universe at any one time, and with enough perception, any event can be predicted based on the initial conditions preceding the event. With this idea in mind, the author of IMT developed the Kashiwagi Solution Model (KSM) which deals with how people best utilize the information present in the universe. Simply put, the ideas presented by KSM encourage people to think in a more logical manner through the utilization of relevant information. The following thesis details an autobiographical case study which focuses on the life of a college student undergoing severe depressive symptoms during the course of their academic career. The usage of concepts stemming from IMT and KSM are then used to determine the root causes of the depression in order to prevent it from ever happening again. The case study acts as a guide to others in order to better help them deal with similar situations that are happening with their lives while providing evidence that the concepts detailed by IMT and KSM are factually relevant.
ContributorsChauhan, Amit (Author) / Kashiwagi, Dean (Thesis director) / Kashiwagi, Jacob (Committee member) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The Community Action Research Experiences (CARE) program collaborated with Singleton Moms, a local non-profit organization that provides financial, psychological, and social support services to single parents with cancer. The purpose of this action research project was to assess the volunteer program at Singleton Moms. Both past and present Singleton Moms' volunteers (N = 123; 87.0% female) completed an online survey assessing their motivation for volunteering and their satisfaction with the organization. A mixed ANOVA was conducted to identify the most important motivation and satisfaction domains and to see if the findings depended on whether the volunteers were current or past volunteers. For the motivation assessment, results indicated that the volunteers rate the cancer specific and moral/human kindness domains as the strongest reasons for motivating them to volunteer at Singleton Moms. In addition, results revealed that the social connection motivation domain was the only domain with differences between the ratings of the past and present volunteers. For the satisfaction assessment, results indicated that the volunteers rate the organizational climate domain as the most fulfilled area of satisfaction within the Singleton Moms' volunteer program. It was also revealed that there were no significant differences between the ratings of the past and present volunteers among all satisfaction domains. Both the quantitative and qualitative findings suggest that Singleton Moms' implications for action may include: 1) a volunteer database audit, 2) streamlining communications, 3) variability in volunteer times, and 4) bolstering volunteer motivation. Implementing some of these actions may help Singleton Moms increase volunteer motivation and satisfaction and thus create a more effective volunteer program. Ultimately, this may encourage volunteers to continue their services at Singleton Moms and thus help Singleton Moms expand their support programs and assist additional families.
ContributorsDubois, Courtney Michelle (Author) / Miller, Cindy (Thesis director) / Dumka, Larry (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor)
Created2016-05
Description
Traumatic brain injury (TBI) is a leading cause of injury related death in the United States. The complexity of the injury environment that follows TBI creates an incomplete understanding of all the mechanisms in place to regulate chemotactic responses to TBI. The goal of this project was to develop a predictive in silco model using diffusion and autocrine/paracrine signaling specific to stromal cell derived factor-1α (SDF-1α) gradient formation after TBI and compare this model with in vivo experimental data. A COMSOL model using Fickian diffusion and autocrine/paracrine reaction terms was generated to predict the gradient formation observed in vivo at three physiologically relevant time points (1, 3, and 7 days). In vivo data was gathered and analyzed via immunohistochemistry and MATLAB. The spatial distribution of SDF-1α concentration in vivo more consistently demonstrated patterns similar to the in silico model dependent on both diffusion and autocrine/paracrine reaction terms rather than diffusion alone. The temporal distribution of these same results demonstrated degradation of SDF-1α at too rapid a rate, compared to the in vivo results. To account for differences in behavior observed in vivo, reaction terms and constants of 1st-order reaction rates must be modulated to better reflect the results observed in vivo. These results from both the in silico model and in vivo data support the hypothesis that SDF-1α gradient formation after TBI depends on more than diffusion alone. Future work will focus on improving the model with constants that are specific to SDF-1α as well as testing methods to better control the degradation of SDF-1α.
ContributorsFreeman, Sabrina Louise (Author) / Stabenfeldt, Sarah (Thesis director) / Caplan, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Community Music Therapy for Cultural Cohesion is the name of the research initiative to create a community music therapy program that addresses community attitudes toward cultural diversity. The program created is titled "Many Peoples, One Voice." Theories and findings in the field of social psychology regarding the formation of intergroup bias and how to prevent it from taking hold inform the goals of the program. Current practices in and theories on community music therapy inform the content, qualities, and perspective of the program. Information from the field of ethnomusicology inform the specific world music traditions incorporated into the program. The culmination of this research and the program it birthed is described in detail to promote a better understanding of the goals, activities, cultural handouts, additional content considerations, and structure of the program as well as the populations it may serve and the adaptions it may include. Finally, the program is related to the current trends in the field of music therapy and its potential to expand into nontraditional need and population areas is considered.
ContributorsOstrowski, Jennifer Lauren (Author) / Rio, Robin (Thesis director) / Little, Bliss (Committee member) / School of Music (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
Previous studies suggest an association between depression and anxiety in childhood and adolescence and increased risk for cardiovascular disease later in life. The aim of the present study was to test whether depression and anxiety symptoms in young adulthood were associated with retinal vessel diameter, a subclinical marker of cardiovascular disease. We further tested whether associations for depression were similar to associations for anxiety. Participants completed questionnaires about their depression and anxiety symptoms and underwent retinal imaging. Retinal vessel diameter was assessed using computer software. Results showed no association between depression or anxiety symptoms and retinal vessel diameter, suggesting that retinal vessel diameter may not signal subclinical cardiovascular risk in young adults with symptoms of depression and anxiety.
ContributorsGandee, Katherine Marie (Author) / Meier, Madeline (Thesis director) / Perez, Marisol (Committee member) / Infurna, Frank (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
There is a widespread inequality in health care access and insured rates suffered by the Latino, Spanish-speaking population in Arizona, resulting in poor health measures and economic burden. The passage of the Affordable Care Act in 2010 provided mechanisms to alleviate this disparity, however, many Latino communities lack accessible information and means to gain access to health insurance enrollment. Chicanos Por La Causa (CPLC) is a community based organizing that provides many services to low-income communities across Arizona, one of which is the CPLC Insurance Program. In collaboration with the Community Action Research Experiences (CARE) at Arizona State University, the program was studied to help address the need of a LOGIC model and evaluation plan to determine its effectiveness. Interviews with three executives within CPLC were conducted in conjunction with a literature review to determine the inputs, strategies, outputs, and outcomes of the LOGIC model that drive CPLC Insurance's mission. Evaluation measures were then created to provide the necessary quantitative data that can best show to what degree the program is achieving its goals. Specifically, the results indicated the key outcomes that drive the LOGIC model, and an evaluation plan designed to provide indicators of these outcomes was produced. The implications of this study are that the suggested data collection can verify how effectively the program's actions are creating positive change, as well as show where further improvements may be necessary to maximize effectiveness.
ContributorsCunningham, Matthew Lee (Author) / Fey, Richard (Thesis director) / Dumka, Larry (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor)
Created2016-05
DescriptionAn artistic film about a girl piecing together memories in search of meaning and hope.
ContributorsFarina, Chiara Rosa (Author) / Chiara, Farina (Thesis director) / Janaki, Cedanna (Committee member) / Scott, Jason (Committee member) / Department of English (Contributor) / School of Film, Dance and Theatre (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12